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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
An intermediate in the dissociated (or type II) fatty acid biosynthesis that occurs in bacteria; generated following the reaction of hexadecenoyl-ACP with malonyl-ACP by the enzyme β-ketoacyl-ACP synthase II, which produces 3-oxo octadecenoyl-ACP
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MF-766 is a potent, selective EP4 antagonist provided for preclinical research. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and as solid quantities for assay and in vivo studies.
Supplied as 10 mM solution in DMSO, 1 mL.
Also available as solids (5 mg-500 mg) for custom preparations.
High purity suitable for research (99.83%).
Molecular weight 478.46, formula C27H21F3N2O3.
Recommended solvent for stocks: DMSO; in vivo vehicle example: 10% DMSO in corn oil.
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ETC-159 is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM. It is intended for research use only.
Inhibits β-catenin reporter activity
Potent and orally available PORCN inhibitor
Active in multiple cancer models with high Wnt signaling
Efficacious in colorectal cancers with R-spondin translocations
Good oral pharmacokinetics in mice with 100% oral bioavailability
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N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrodes. Calcium ion-selective electrodes can be used to measure intracellular free calcium.
Lipophilic ionophore
Used in preparing calcium ion-selective electrodes
Enables measurement of intracellular free calcium
For research use only
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Lycopene is a carotenoid found in many red fruits and vegetables such as watermelon pink guava and tomato. Lycopene is a potent antioxidant. It is suggested that lycopene is used by the plant to protect against reactive oxygen species (ROS).
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Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor. This compound is intended for research use only. In vitro studies show that delivery of Bay 65-1942 prior to ischemia significantly decreases left ventricular infarct size. In vivo, it demonstrates synergistic inhibition of cell viability and induces caspase 3/7 activation when combined with AZD6244 in MYL-R cells.
Acts as an ATP-competitive and selective IKKβ inhibitor
Decreases left ventricular infarct size in vitro
Attenuates CK-MB levels in vivo
Demonstrates synergistic inhibition of cell viability with AZD6244
Induces caspase 3/7 activation with AZD6244
Suitable for research applications
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Butyne-DOTA-tris(t-butyl ester) is a DOTA-derived bifunctional chelator featuring an alkyne functional group and tert-butyl protected carboxylates. It is intended for conjugation to peptides and radionuclides in radiopharmaceutical and imaging probe synthesis; the protected ester form simplifies handling and allows controlled deprotection to the metal-chelating DOTA core.
Bifunctional chelator for peptide and radionuclide conjugation.