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Organic compounds with acidic properties, and will commonly have carboxylic acids or similar functional groups in their structure. Derived compounds are also included.
A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively); also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively)
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Cesium trifluoroacetate is a new medium for equilibrium density gradient centrifugation replacing cesium chloride Its recovery rate is stable and is particularly suited to isolation of highly pure and intact RNAs It is characterized by the inhibitory effect on RNase activity and is effective for purification of mRNAs It also solubilizes proteins and accelerates dissociation of proteins from nucleic acids and therefore it can isolate highly pure RNAs withuot protein contamination at high yields For research use only RUO
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Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
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Also available in 1 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki 14 nM; IC50 130 nM). Purity 99.95%
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Also available in 50 mg, 100 mg and bulk. Please contact Fisher for quotes. R-(+)-EU-1180-453 is a novel GluN2C/D selective NMDAR-positive modulator for the study of neurological disorders. Purity 100%
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Medchemexpress, HY-108006 5mg Mirogabalin besylate CAS:1138245-21-2 Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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