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PR-924 is a selective tripeptide epoxyketone inhibitor targeting the immunoproteasome subunit LMP-7. It covalently modifies proteasomal N-terminal threonine active sites, exhibits low-nanomolar potency (IC50 ≈ 22 nM), and has demonstrated antiproliferative and pro-apoptotic activity in multiple myeloma models. Intended for research use only.
Selective LMP-7 inhibition with low-nanomolar potency (IC50 ≈ 22 nM).
Covalent, irreversible mechanism of action for target engagement.
Demonstrated antiproliferative and pro-apoptotic activity in preclinical models.
High purity to support reproducible experimental results.
Available in multiple solid and solution formats for flexible dosing.
Supplied for research use only; not for human use.
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N-Nitrosodiethylamine (N-Nitroso-diethylamine NDEA diethylnitrosamine DEN) is DNA reactive after bioactivation and produces tumors in many animal species N-Nitrosodiethylamine can be used to induce animal models of Lung Carcinoma
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N-Nitrosodiethylamine (N-Nitroso-diethylamine NDEA diethylnitrosamine DEN) is DNA reactive after bioactivation and produces tumors in many animal species N-Nitrosodiethylamine can be used to induce animal models of Lung Carcinoma
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N-Nitroso-N-methylurea is a potent carcinogen, mutagen, and teratogen. It acts as a direct-acting alkylating agent that interacts with DNA, targeting multiple animal organs to induce various cancers and/or degenerative diseases. It is also utilized as a precursor in the synthesis of diazomethane.
Potent carcinogen, mutagen, and teratogen
Direct-acting alkylating agent that interacts with DNA
Targets multiple animal organs to induce various cancers and/or degenerative diseases
Precursor in the synthesis of diazomethane
Can be used to construct rat tumor models
Increases cellular NF-κB activity and I-κBα phosphorylation in human malignant keratinocytes
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N-Nitroso-N-methyl-4-aminobutyric acid is a tobacco-specific nitrosamine provided as a high-purity research reagent for analytical and toxicological studies. It is intended for laboratory research use only and supplied as a solid; handle with appropriate carcinogen safety precautions.
Tobacco-specific nitrosamine and carcinogen.
Used as an analytical standard and in toxicology studies.
Molecular weight 146.14 g/mol.
Chemical formula C5H10N2O3.
CAS number 61445-55-4.
Reported purity 99.9%.
Supplied as a 100 mg solid.
Certificate of analysis available.
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N-Nitroso-3-azabicyclo[3.3.0]octane-d4 is the deuterium labeled N-Nitroso-3-azabicyclo[3.3.0]octane. Deuterium substitution has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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