Organooxygen compounds
Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG
Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.
- Selective 5-HT1A receptor agonist for receptor pharmacology studies.
- Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
- High chemical purity suitable for analytical and in vivo research.
- Supplied with certificate of analysis and safety data sheet.
- Available in multiple pack sizes for small-scale and bulk use.
- Not for human or clinical use; for research use only.
Medchemexpress LLC Tiagabine hydrochloride | 145821-59-6 | MFCD07369025 | 99.4% | 50 MG
Tiagabine hydrochloride is an anticonvulsant agent and a selective inhibitor of the GAT-1 GABA transporter, with a Ki of approximately 0.1 μM. It potently and selectively inhibits GABA reuptake with IC50s of 67, 446, and 182 nM for [3H]GABA uptake in synaptosomes, neurons, and glia. This compound also exhibits neuroprotective properties.
- Selective inhibitor of GAT-1 GABA transporter
- Potently and selectively inhibits GABA reuptake
- Exhibits neuroprotective properties
- Protects neurons against mutant huntingtin-induced toxicity
- Increases viability of SH-SY5Y cells
- Neuroprotective in mouse models of Huntington's disease
- Reduces dopaminergic neuronal loss in PD mouse models
- Shows anti-allodynic effect in a rat model of neuropathic pain
- Antinociceptive effects against acute thermal pain in mice
- Suppresses pentylenetetrazole-induced seizures and improves cognitive parameters in mice
Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | MFCD17215959 | 99.9% | 369.89 | C18H28ClN3O3 | 10 MG
VU0357017 hydrochloride is a brain-penetrant, selective allosteric agonist of the M1 muscarinic acetylcholine receptor used as a research tool to probe M1 receptor pharmacology and signaling. Supplied as the hydrochloride salt, the compound is characterized by a defined molecular weight and high reported purity.
- Potent M1 allosteric agonist with reported EC50 ≈ 477 nM.
- Brain-penetrant small molecule suitable for in vitro and in vivo studies.
- High chemical purity as provided by manufacturer.
- Provided as a hydrochloride salt for improved solubility.
- Available in small research pack sizes for laboratory use.
Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 100.0% | 362.30 | 50 MG
Clemizole hydrochloride is an H1 histamine receptor antagonist that has been shown to substantially inhibit HCV replication. It also acts as an inhibitor of the TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, while its EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication in cell culture.
- Suppresses NS4B's RNA binding.
- Offers minimal host cell toxicity.
- Functions as a novel inhibitor of TRPC5 channels.
- Efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range.
- Exhibits six-fold selectivity for TRPC5 over TRPC4β.
- Displays almost 10-fold selectivity over TRPC3 and TRPC6.
Medchemexpress LLC Terazosin hydrochloride dihydrate | 70024-40-7 | 99.9% | 50 MG
Terazosin hydrochloride dihydrate is a quinazoline derivative, and it acts as a competitive and orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and facilitating the opening of the bladder. This compound shows potential for treating benign prostatic hyperplasia (BPH) and high blood pressure. It is intended for research use only and is not sold to patients.
- Competitively blocks α1-adrenoceptors.
- Can be administered orally.
- Helps in relaxing blood vessels.
- Aids in the opening of the bladder.
- Has potential for the treatment of benign prostatic hyperplasia (BPH) and high blood pressure.
- Suitable for research applications.
Medchemexpress LLC Leelamine hydrochloride | 16496-99-4 | 98.1% | 321.93 | 10 MG
Leelamine hydrochloride is a tricyclic diterpene molecule extracted from the bark of pine trees. It acts as a cannabinoid receptor type 1 (CB1) agonist and an inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, functioning independently of androgen receptor status. It also suppresses the transcriptional activity of the androgen receptor, which regulates fatty acid synthesis.
- Cannabinoid receptor type 1 (CB1) agonist
- Inhibits SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells
- Suppresses transcriptional activity of androgen receptor
- Extracted from the bark of pine trees