Organosulfur Compounds
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 1 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. It is used in cancer research.
- Inhibits mTORC1 pathway
- Metabolite of Sulindac
- Inhibits colon cancer cell growth
- Induces cell cycle arrest
- Used in cancer research
Medchemexpress LLC Iduronate 2-sulfatase protein, human | 50936-59-9 | >95.0% | 1 MG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized for research use. It participates in the degradation of dermatan sulfate and heparan sulfate, and is suitable for biochemical assays and enzyme activity studies.
- Expression system: HEK293 cells
- Tag: C-terminal His
- Purity: >95.0% by reducing SDS-PAGE
- Molecular weight: ~75-95 kDa (glycosylated)
- Formulation: lyophilized from 0.22 μm filtered PBS, pH 7.4
- Storage: store lyophilized at -20°C; aliquot and freeze at -80°C for long term
- Activity: specific activity ~6.123 pmoL/min/μg
eMolecules 67-68-5 | Dimethyl sulfoxide, meets analytical specification of Ch.P. | ChemScene | MFCD00002089 | 78.130 | C2H6OS | 99.000 | CS(C)=O | 110g | 717421095
Dimethyl sulfoxide, meets analytical specification of Ch.P. | ChemScene | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 99.000 | CS(C)=O | 110g | 717421095
Medchemexpress LLC KAT modulator-1 | 1314006-43-3 | C20H36O2 | 5 MG
KAT modulator-1 is a compound identified as a KAT modulator that interacts with p300 full-length, but not its catalytic domain. It is provided as a solid and is intended for laboratory chemicals, manufacture of substances, and epigenetics research, including drug screening applications.
- Targets histone acetyltransferase
- Used in cancer research
- Interacts with p300 full-length
- Suitable for epigenetics research
- Identified for laboratory use and drug screening
- Provided as a solid
- For research use only
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.88% | 100 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). It selectively reduces Aβ42 production in favor of shorter Aβ species, and it can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM)
- Selectively reduces Aβ42 production in favor of shorter Aβ species
- Can be used for researching Alzheimer's disease
Medchemexpress LLC LRH-1 modulator-1 | 2244781-29-9 | 98.0% | C28H36N2O2S | 10MG
LRH-1 modulator-1 is a research-grade small molecule characterized as a potent agonist/modulator of the liver receptor homolog-1 (LRH-1). The product is provided with analytical documentation and recommended storage and solubility guidance for laboratory and preclinical use.
- Potent LRH-1 modulator/agonist for receptor biology studies.
- High purity (98.0%) suitable for analytical and biological assays.
- Supplied with certificate of analysis, HNMR, and LCMS data for verification.
- Soluble in DMSO; in vivo formulation protocols are provided.
- Stable under specified storage conditions with solvent-specific guidelines.
Apexbio Technology LLC Sulindac 38194-50-2 1g
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
![Medchemexpress LLC 2-Quinoxalinecarboxamide, N-[2-[3-[(4-amino-1-piperidinyl)methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]- | 925437-38-3 | 96.2% | 483.59 | 500 UG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385638-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Quinoxalinecarboxamide, N-[2-[3-[(4-amino-1-piperidinyl)methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]- | 925437-38-3 | 96.2% | 483.59 | 500 UG
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. It significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). This modulator regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases and inflammatory diseases. It also causes a significant decrease in MCP-1 expression in a human leukocyte (WBC) model, indicating its potential to inhibit inflammatory responses.
- Activates sirtuin activity.
- Downregulates MCP-1 expression.
- Upregulates FGF21 expression.
- Shows potential for studying metabolic diseases.
- Shows potential for studying inflammatory diseases.
Medchemexpress LLC mGluR3 modulator-1 | 374548-18-2 | C16H21N3O | 5 MG
mGluR3 modulator-1 (compound 3) is a mGluR3 modulator with an EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay. It is intended for research use only.
- Solid, white to off-white appearance
- Purity of 98.67%
- Molecular weight: 271.36
- Can be stored as powder at -20°C for 3 years, or 4°C for 2 years
- Can be stored in solvent at -80°C for 6 months, or -20°C for 1 month
- Soluble in DMSO at 125 mg/mL
Medchemexpress LLC LRH-1 modulator-1 | 2244781-29-9 | 99.4% | 464.66 | 5 MG
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. It has anti-inflammatory effects in intestinal organoids, inducing the anti-inflammatory cytokine IL-10 and reducing the inflammatory cytokines IL-1b and TNFa.
- Potent LRH-1 modulator/agonist
- Anti-inflammatory effects in intestinal organoids
- Induces anti-inflammatory cytokine IL-10
- Reduces inflammatory cytokines IL-1b and TNFa
Medchemexpress LLC (R)-Sulforaphane | 142825-10-3 | 99.95% | 177.29 | 5 MG
(R)-Sulforaphane is an orally active and potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. It primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. This compound modulates gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1.
- Can be used in studies of tumor biology, antioxidant defense mechanisms, inflammation, and immune responses
- Promotes transcription of tumor-suppressing proteins
- Effectively inhibits HDAC activity
- Offers cardiac protection by activating the Keap1/Nrf2/ARE pathway and inducing HO-1 expression
- Suppresses high glucose-induced pancreatic cancer via AMPK-dependent signal transmission
- Storage at -20°C, protect from light, stored under nitrogen
- Unstable in solutions, freshly prepared is recommended
Medchemexpress LLC Quetiapine sulfoxide dihydrochloride | 329218-11-3 | MFCD09031385 | 98.6% | 472.43 g·mol-1 | C21H27Cl2N3O3S | 10 MG
Quetiapine sulfoxide dihydrochloride is the dihydrochloride salt of quetiapine sulfoxide, a primary metabolite of the antipsychotic quetiapine. It is provided as a research-grade biochemical reference for analytical, metabolic, and pharmacokinetic studies.
- Main metabolite of quetiapine used in metabolism research and metabolite identification.
- Provided as a stable dihydrochloride salt to improve solubility and handling.
- High purity suitable for analytical and reference-standard applications.
- Available in small milligram pack sizes and as a 10 mM solution for assay preparation.