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Phenylpropaniods are organic compounds characterized by having an aromatic ring and a three-carbon propene tail. Polyketides are compounds characterized by having two or more carbonyl functional groups connected with a single carbon atom.
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Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Daunorubicin hydrochloride (Rubidomycin hydrochloride) an anthracycline aminoglycoside antineoplastic inhibits DNA replication and repair and RNA and protein synthesis. purity: 99%
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Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
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Daunorubicin hydrochloride is an anthracycline antibiotic and potent cytotoxic research compound that intercalates DNA and inhibits topoisomerase II. Provided as the hydrochloride salt for research use, it is commonly used in oncology and biochemical studies where controlled, small-quantity reagent handling and high-purity material are required.
Anthracycline antibiotic with cytotoxic activity.
Potent topoisomerase II inhibitor causing DNA intercalation.
Hydrochloride salt form for enhanced solubility and handling.
High purity suitable for analytical and biological assays.
Molecular weight 563.98 g/mol; formula C27H30ClNO10.
Supplied in small measured quantities for research workflows.
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BIIE-0246 hydrochloride is a selective, non-peptide antagonist of the neuropeptide Y Y2 receptor supplied as the hydrochloride salt for research use. It is used in pharmacological studies to probe NPY-mediated signaling and is provided at high purity for in vitro and in vivo experiments.
Selective NPY Y2 receptor antagonist
High purity (>98.0%) suitable for research
Hydrochloride salt for improved aqueous solubility
Molecular formula C49H57N11O6; molar mass 896.0 g/mol
Available in small research pack sizes, for example 5 MG
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BIIE-0246 is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor (NPY2R) used in preclinical neuroscience research. It has an IC50 of approximately 15 nM (rat [125I]PYY3-36) and modulates downstream signaling pathways including p-AKT and p44/42 MAPK. The compound is supplied as a 10 mM solution in DMSO with reported high purity for research use only.
Potent NPY Y2 receptor antagonist (IC50 ~15 nM).
Ready-to-use 10 mM solution in DMSO for in vitro assays.
High reported purity (99.1%).
Molecular weight 896.05 g·mol⁻¹ and formula C49H57N11O6.
Suitable for studies of NPY2R signaling and related pathways.
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BIIE-0246 (AR-H 053591) is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor used as a research reagent to probe NPY2R-mediated signaling. It is provided as a solid powder for in vitro and in vivo applications, with a reported IC50 of approximately 15 nM (rat [125I]PYY3-36). Intended for research use only.
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AVN-492 is a highly selective antagonist of the 5-HT6 receptor used as a research compound to probe serotonergic mechanisms relevant to cognition and neurodegeneration. It exhibits picomolar affinity (Ki = 91 pM) and demonstrates favorable in vitro and in vivo ADME properties including brain penetration in preclinical models.
High potency: Ki = 91 pM at 5-HT6 receptor.
High selectivity for 5-HT6 over other serotonin receptors.
Typical purity 99.3% for reliable experimental performance.
Soluble in DMSO (50 mg/mL) and compatible with in vivo formulations.
Powder stability: -20°C storage for extended shelf life.
Supplied in small research quantities suitable for preclinical studies.
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