Phenylpropanoids and polyketides
Medchemexpress LLC 5,7-dimethoxyflavone | 21392-57-4 | MFCD00016943 | 282.29 g/mol | C17H14O4 | 10 MG
5,7-Dimethoxyflavone is a flavone derivative supplied as an analytical standard for research and analytical applications. It occurs naturally in Kaempferia parviflora and is used in studies of metabolic enzyme interactions, transporter inhibition, and biological activity profiling.
- Analytical standard suitable for assay and quantification.
- Natural flavone component used in phytochemical research.
- Documented inhibitor activity against cytochrome P450 enzymes and BCRP, useful in metabolism and transporter studies.
- Supplied in small mass quantities appropriate for analytical work.
- Molecular formula C17H14O4 and molecular weight 282.29 g/mol.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | 50 G
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6. This compound has been shown to significantly decrease alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, while also restoring total protein (TP) and albumin (TA) levels in serum and preventing oxidative stress. Additionally, 7-Methylcoumarin can reduce the mitotic activity of *A. sativum* promeristem.
- Potent hepatoprotective properties.
- Antioxidant properties.
- Mechanism-based inhibitor for CYP2A6.
- Decreases ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage.
- Restores total protein and albumin levels in serum.
- Prevents oxidative stress.
- Can decline mitotic activity of *A. sativum* promeristem.
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | MFCD00006835 | 50 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* that exhibits anti-inflammatory activity. It protects renal cells from nicotine-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This orally active compound also inhibits PKM2, COX-2, and 5-LOX, and has demonstrated antioxidant activity and efficacy in various animal models.
- Isolated from *Clerodendrum phlomidis*
- Exhibits anti-inflammatory activity
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2, COX-2, and 5-LOX
- Orally active
- Reduces malondialdehyde (MDA) and reactive oxygen species (ROS) levels
- Increases superoxide dismutase (SOD) and glutathione (GSH) levels
- Ameliorates ischemia/reperfusion injury
- Improves high-fat diet-induced non-alcoholic fatty liver disease and obesity
- Purity of 99.89%
- Appearance is a white to off-white solid
Medchemexpress LLC Dihydrocoumarin (Hydrocoumarin) | 119-84-6 | 148.16 | 50 G
Dihydrocoumarin is a compound found in Melilotus officinalis. It is a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
- Found in Melilotus officinalis.
- Yeast Sir2p inhibitor.
- Inhibits human SIRT1 (IC50 of 208 μM) and SIRT2 (IC50 of 295 μM).
- Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay.
- Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner.
- Increases p53 lysine 373 and 382 acetylation in the TK6 cell line.
Medchemexpress LLC Gallocatechin gallate | 5127-64-0 | 5 MG
Gallocatechin gallate is a flavonoid product isolated from the herbs of Celastrus orbiculatus. This chemical compound is provided as a solid, typically white to off-white in appearance, with a purity of 98%.
- Molecular weight: 458.37
- Chemical formula: C22H18O11
- Recommended storage at -20°C, sealed, away from moisture and light
- In solvent storage at -80°C for 6 months or -20°C for 1 month
- For research use only
Medchemexpress LLC 4-Hydroxycoumarin (standard) | 1076-38-6 | 50 MG
4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin, intended for research and analytical applications. It is an orally active coumarin derivative and a versatile heterocyclic scaffold, frequently used in the synthesis of diverse organic compounds. The product exhibits both electrophilic and nucleophilic properties.
- Analytical standard.
- Intended for research and analytical applications.
- Orally active coumarin derivative.
- Versatile heterocyclic scaffold.
- Used in the synthesis of various organic compounds.
- Possesses both electrophilic and nucleophilic properties.
- Functions as an HIV protease inhibitor.
- Functions as a tyrosine kinase inhibitor.
- Displays anti-inflammatory effects.
- Displays antibacterial effects.
- Displays anti-tumor effects.
TARGETMOL CHEMICALS INC HX 531 10MG
Also available in 1 mg 5 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. HX 531 is a potent antagonist of the retinoid X receptor with an IC50 value of 18 nM. purity: 99%
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g·mol⁻¹ | C10H6N2O | 1 ML
Tyrphostin 8 is a small-molecule inhibitor that targets tyrosine kinases and GTPases and also inhibits calcineurin phosphatase activity. It is supplied at high purity for use in biochemical and cellular assays; chemical identifiers include CAS 3785-90-8, formula C10H6N2O, and molecular weight 170.17 g·mol⁻¹.
Medchemexpress LLC Gallocatechin gallate | 5127-64-0 | 1 MG
Gallocatechin gallate is a flavonoids product that can be isolated from the herbs of Celastrus orbiculatus. It is intended for research use only.
- Molecular weight: 458.37
- Formula: C22H18O11
- Appearance: Solid
- Color: White to off-white
- Purity: 98%
- Storage: -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
- Structure classification: Flavonoids
- Initial source: Plants, celastraceae, celastrus, Celastrus orbiculatus Thunb.
TARGETMOL CHEMICALS INC APIGENIN-7-GLUCURONIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s 12.87 22.39 17.52 0.27 uM for MMP-3 MMP-8 MMP-9 MMP-13 respectively). purity: 99%