Diterpenoids
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Sigma Aldrich Fine Chemicals Biosciences Docetaxel purum, >=97.0% (HPLC) | 114977-28-5 | MFCD00800737 | 25MG
Docetaxel purum, >=97.0% (HPLC) | Purity: >=97.0% (HPLC) | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 | 25MG
TARGETMOL CHEMICALS INC Docetaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 uM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity. Purity 99.1%
Selleck Chemical LLC Nab-Paclitaxel-E1068-100MG
Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1 9 It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system Solutions are unstable and should be fresh-prepared
Abcam Myricetin, irreversible Tr x R inhibitor, 25MG
MW 318.24 g/mol, Purity >97%. Directly inhibits MEK, JAK1, Akt and MKK4 kinase activity. Able to inhibit cytochrome P450 3A4 and 2C9 (IC₅₀ = 7.81 and 13.5 μM, respectively). .
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 25 MG
Resiniferatoxin, also known as (+)-Resiniferatoxin, is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. Isolated from the *Euphorbia resinifera* plant, this compound eliminates TRPV1+ primary sensory afferents and can blunt cardiac sympathetic afferent reflex for an extended period. This product is intended for research use only.
- Selective agonist for the TRPV1 receptor
- Isolated from the *Euphorbia resinifera* plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
Apexbio Technology LLC Resiniferatoxin 1mg
Resiniferatoxin (CAS 57444-62-9) is a potent selective agonist of the transient receptor potential vanilloid 1 (TRPV1) channel derived from plant sources By activating TRPV1 it induces sustained calcium influx in TRPV1-expressing sensory neurons leading to their desensitization or ablation In animal studies resiniferatoxin has been shown to induce long-lasting elimination of TRPV1-positive primary sensory afferents and blunt associated neural reflexes including those mediating cardiac sympathetic input Resiniferatoxin is widely used in research to investigate pain pathways sensory neuron function and neurogenic inflammation
Abcam LDN-57444, UCH-L1 inhibitor, 5MG
MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 99.8% | 628.71 g/mol | C37H40O9 | 10 MG
Resiniferatoxin is a highly potent, naturally derived agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel. It is used in laboratory research to ablate or modulate TRPV1-expressing sensory neurons and to study pain signaling, neurobiology, and cardiac sympathetic afferent reflexes. Supplied as a high-purity solid with storage and solvent guidance, it is intended for research use only (not for human use).
- Potent TRPV1 agonist for targeted neuronal ablation and modulation.
- High chemical purity (99.77%) suitable for sensitive assays.
- Molecular weight 628.71 g/mol and formula C37H40O9.
- Stable solid; store protected from light at -20°C; in solution, store at -80°C for long-term stability.
- Soluble in DMSO; in vitro and in vivo vehicle preparation guidance available.
- Supplied in small milligram-scale quantities appropriate for research applications.
Abcam LDN-57444, UCH-L1 inhibitor, 25MG
MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Aphidicolin 17-acetate
Chemical. CAS 51103-57-2. Formula C22H36O5. MW 380.5. Isolated from Phoma sp. BS 7210. Phytotoxin inhibits root growth of seeding. Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis competition with dCTP.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.
- Inhibits DNA polymerase α and δ.
- Functions as an antibiotic from *Cephalosporium aphidicola*.
- Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
- Modulates cell cycle, arresting cells at G2 phase.
- Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
- Aphidicolin glycinate demonstrates anti-tumor activity in murine models.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 50 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola* and inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibitor of DNA polymerase α and δ
- Prevents mitotic cell division
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
AdipoGen (+)-Aphidicolin,Chemical. CAS: 38966-21-1
(+)-Aphidicolin, AdipoGen Life Sciences. Chemical. CAS: 38966-21-1. Formula: C20H34O4. MW: 338.5. Isolated from Phoma sp. BS 7210. Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA methylation/demethylation modulator. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.