Diterpenoids
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 10 MM 1 ML
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. It eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It is for research use only.
- Selective agonist for the transient receptor potential vanilloid 1 (TRPV1) receptor.
- Can be isolated from the Euphorbia resinifera plant.
- Eliminates TRPV1+ primary sensory afferents.
- Blunts cardiac sympathetic afferent reflex for a relatively long period.
- Causes prolonged channel opening and calcium influx, leading to cytotoxicity in TRPV1-positive pain fibers or cell bodies.
- For research use only.
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000388040-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 1 ML
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. It also demonstrates anti-orthopoxvirus activity and enhances apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits the growth of herpes simplex virus
- Shows anti-orthopoxvirus activity
- Enhances apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cells
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 25 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which functions by interfering with DNA polymerase activity to prevent mitotic cell division. This antibiotic, originating from the mold Cephalosporium aphidicola, is known for its ability to inhibit cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Furthermore, it demonstrates anti-orthopoxvirus activity and enhances apoptosis when induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Functions as an antibiotic
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
- Targets DNA/RNA synthesis, HSV, and apoptosis pathways
- Applied in infection and inflammation/immunology research
Medchemexpress LLC Aphidicolin | 38966-21-1 | 1 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola*, inhibiting cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Interferes with DNA polymerase activity
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
Medchemexpress LLC Phytol | 150-86-7 | 1 ML
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol extracted from chlorophyll. It exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. It is intended for research use only and not for sale to patients.
- Exhibits antioxidant activity
- Shows anti-inflammatory properties
- Possesses anti-schistosomiasis activity
- Demonstrates antibacterial activities
- Reduces motor activity and causes death in worms
- Inhibits osteoclast differentiation and oxidative stress
- Reduces parasite numbers in mice infected with C. mansoni
- Improves anemia and oxidative brain damage in Plasmodium berghei infected mice
Medchemexpress LLC Phytol (Standard) | 150-86-7 | 25 MG
Phytol (Standard) is an orally active diterpenoid alcohol that serves as an analytical standard. It can be extracted from chlorophyll and exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. This product is intended for research and analytical applications.
- Analytical standard for research and analytical applications
- Extracted from chlorophyll
- Exhibits antioxidant activity
- Exhibits anti-inflammatory activity
- Exhibits anti-schistosomiasis activity
- Exhibits antibacterial activity
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Apexbio Technology LLC Phytol 150-86-7 250g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models
Medchemexpress LLC (5E,9E,13E)-Teprenone | 3796-63-2 | 99.9% | 100 MG
(5E,9E,13E)-Teprenone is an isomer with antiulcer activity. It induces the transcriptional activation of HSP genes, which may enhance gastric mucosal defense under stress conditions.
- Antiulcer activity.
- Induces transcriptional activation of heat shock protein protein genes.
- May increase gastric mucosal defense at conditions of stress.
- Available in various quantities.
- Purity of 99.9%.
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)