Diterpenoids
Cayman Chemical Docetaxel-d9 500ug
An internal standard for the quantification of docetaxel by GC- or LC-MS
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 G
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity
Cayman Chemical 10-acetyl Docetaxel 100mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
Medchemexpress LLC Paclitaxel | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 100 MG
Paclitaxel is an analytical standard and a naturally occurring antineoplastic agent. It is intended for research and analytical applications, stabilizing tubulin polymerization, causing mitotic arrest, apoptotic cell death, and inducing autophagy. This compound serves as a reference standard for assays and is utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for paclitaxel
- Naturally occurring antineoplastic agent
- Stabilizes tubulin polymerization
- Causes mitotic arrest
- Induces apoptotic cell death
- Induces autophagy
- Reference standard for assays
- Used in HPLC, GC, and MS experiments
Medchemexpress LLC Paclitaxel | 33069-62-4 | 99.97% | C47H51NO14 | 5 G
Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can cause both mitotic arrest and apoptotic cell death, and it also induces autophagy.
- Naturally occurring antineoplastic agent.
- Stabilizes tubulin polymerization.
- Causes mitotic arrest.
- Induces apoptotic cell death.
- Induces autophagy.
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 25 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, intended for research and analytical applications. It is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization, causing mitotic arrest, apoptotic cell death, and inducing autophagy.
- Used as an analytical standard for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Naturally occurring antineoplastic agent.
- Stabilizes tubulin polymerization.
- Causes mitotic arrest and apoptotic cell death.
- Induces autophagy.
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 50 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, a naturally occurring antineoplastic agent. It is intended for research and analytical applications, serving as a reference standard for assays.
- Stabilizes tubulin polymerization.
- Causes both mitotic arrest and apoptotic cell death.
- Induces autophagy.
- Used in qualitative, quantitative, and methodological research experiments.
- Commonly used in HPLC, GC, and MS applications.
AdipoGen Paclitaxel
Chemical. CAS 33069-62-4. Formula C47H51NO14. MW 853.91. Synthetic. Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposis sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases CKDs and the c-Jun N-terminal kinase/stress activated protein kinase JNK/SAPK. Immunosuppressor, immunostimulant and TRAIL sensitizer.
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3958841 SIGMA PACLITAXEL 300MG
Apexbio Technology LLC PACLITAXEL-D5-1MG
Paclitaxel-d5 (CAS No 1129540-33-5) is a deuterated analog of paclitaxel used in biomedical research primarily to study the pharmacokinetics and metabolism of the parent compound Originating from the bark of the Pacific yew tree paclitaxel acts by stabilizing microtubules and inhibiting their depolymerization thus blocking cell division and inducing apoptosis in cancer cells Its mechanism of action specifically affects the tubulin-microtubule pathway Paclitaxel-d5 exhibits activity in the nanomolar to low micromolar range in vitro making it a valuable tool in cell models and animal studies aimed at understanding cancer cell sensitivity or resistance to taxanes It is frequently used in drug screening assays to evaluate potential therapeutic efficacy or investigate drug interactions Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | 807.88 | C43H53NO14 | 10 MG
Docetaxel (standard) is an analytical reference of the chemotherapeutic agent docetaxel supplied for research and analytical applications. It acts as a microtubule depolymerization inhibitor that arrests cells at G2/M and promotes apoptosis. The product is provided in small vial sizes for laboratory workflows and is accompanied by supporting documentation (SDS, COA).
- High purity suitable for analytical applications.
- Molecular weight 807.88.
- CAS number 114977-28-5 for unambiguous identification.
- Available in multiple small vial sizes for flexibility in experiments.
- Intended for research and analytical use only.
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 98.1% | 858.94 | C47H46D5NO14 | 10 MG
Paclitaxel-d5 is a deuterium-labeled analog of paclitaxel supplied as a white to off-white solid for use as a tracer and internal standard in quantitative analytical methods. It stabilizes tubulin polymerization and is intended for research use in NMR, GC-MS, and LC-MS applications.
- High purity (98.1%).
- Molecular weight 858.94 Da.
- White to off-white solid form.
- Soluble in DMSO and DMF; moderately soluble in ethanol.
- Stable storage as powder at -20 °C for long-term retention.
- Designed for use as tracer and internal standard in quantitative assays.
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000388040-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG