Diterpenoids
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-1g
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Selleck Chemical LLC Paclitaxel S1150-100mg
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
TARGETMOL CHEMICALS INC Resiniferatoxin 1MG
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-gamma, IL-1beta, TNF-alpha, NO, and PGE. Purity 99.12%
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | 38966-21-1 | MFCD00083214 | 1MG
Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | Purity: >=98% (TLC) | Mol Wt: 338.48 | 38966-21-1 | MFCD00083214 | 1MG
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin, Ready Made Solution from Nigrospora sphaerica | 38966-21-1 | 1ml
Aphidicolin, Ready Made Solution from Nigrospora sphaerica | Mol Wt: 338.48 | 38966-21-1 | 1ml
Cayman Chemical -AphIdIcolIn 5mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Cayman Chemical 10-acetyl Docetaxel 100mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 5 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*. This compound has been extensively used for treating cardiovascular diseases and demonstrates an entry-blocking effect against MERS-CoV.
- Extracted from *Salvia miltiorrhiza Bunge*
- Used for treating cardiovascular diseases
- Exhibits entry-blocking effect for MERS-CoV
- Attenuates atherosclerosis in ApoE-/- mice
- Inhibits LOX-1, NOX4, and NF-κB expression in aorta
- Improves cardiac function and reduces infarct size in myocardial ischemia-reperfusion rats
- Induces caspase-dependent apoptosis and autophagy in colon cancer cells
- Potentially a safe, high-throughput screening compound for MERS-CoV entry inhibitors
- Purity: 99.57%
- Appearance: Solid, brown to red
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 1 MG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a natural antineoplastic agent that works by stabilizing tubulin polymerization. This product is strictly for research purposes and is not intended for patient use. Deuteration, the process of incorporating stable heavy isotopes into drug molecules, is primarily employed as a tracer for quantitation during the drug development process and can impact the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stabilizes tubulin polymerization
- For research use only