Diterpenoids
Cayman Chemical 10-acetyl Docetaxel 100mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
AdipoGen Resiniferatoxin high purity
Chemical. CAS 57444-62-9. Formula C37H40O9. MW 628.72. Isolated from Euphorbia resinifera. Highly potent TRPV1 agonist. Resiniferatoxin RTX is a phorbol-related diterpene ester analog of capsaicin. RTX is a highly potent transient receptor potential vanilloid 1 TRPV1 agonist Ki=43pM and acts as a selective modulator of primary afferent neurons. TRPV1 or vanilloid receptor 1 is a non-selective cation channel that is involved in the detection and transduction of nociceptive stimuli. TRPV1 is expressed in the plasma membrane of sensory neurons and stimulation by RTX causes this ion channel to become permeable to cations, especially calcium. The influx of cations causes the neuron to depolarize, transmitting signals similar to those that would be transmitted if the innervated tissue were being burned or damaged. This stimulation is followed by desensitization and analgesia, in part because the nerve endings die from calcium overload.
Apexbio Technology LLC Docetaxel 114977-28-5 100mg
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
TARGETMOL CHEMICALS INC Resiniferatoxin 1MG
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-gamma, IL-1beta, TNF-alpha, NO, and PGE. Purity 99.12%
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | 38966-21-1 | MFCD00083214 | 1MG
Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | Purity: >=98% (TLC) | Mol Wt: 338.48 | 38966-21-1 | MFCD00083214 | 1MG
TARGETMOL CHEMICALS INC Cucurbitacin IIA 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3. Purity 98.62%
TARGETMOL CHEMICALS INC 7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells. Purity 98.05%
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers