Diterpenoids
Cayman Chemical 7-acetyl PaclItaxel 10mg
An inhibitor of native (IC50 0.37 nM) and mutant Bcr-Abl inhibits the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I (IC50 2 nM) as well as Bcr-AblQ252H Bcr-AblY253F Bcr-AblM351T and Bcr-AblH396P mutants (IC50s 0.44 0.3 0.3 and 0.34 nM respectively) selective for Bcr-Abl and these mutants over the insulin receptor IGF-1R Aurora A kinase and Cdk2/cyclin E but does inhibit c-Src VEGFR2 FGFR1 and PDGFRa (IC50s 5.4 1.5 2.2 and 1.1 nM respectively) inhibits proliferation of Ba/F3 cells expressing native (IC50 0.5 nM) or mutant Bcr-Abl (IC50s 0.5-36 nM) reduces tumor growth in a Ba/F3 Bcr-AblT315I mouse xenograft model at 10-30 mg/kg
TARGETMOL CHEMICALS INC Resiniferatoxin 1MG
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-gamma, IL-1beta, TNF-alpha, NO, and PGE. Purity 99.12%
TARGETMOL CHEMICALS INC 7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells. Purity 98.05%
AdipoGen Aphidicolin 17-acetate
Chemical. CAS 51103-57-2. Formula C22H36O5. MW 380.5. Isolated from Phoma sp. BS 7210. Phytotoxin inhibits root growth of seeding. Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis competition with dCTP.
Cayman Chemical Docetaxel-d9 500ug
An inhibitor of Mps1 (IC50 145 nM) 1000-fold selective for Mps1 over a panel of 352 kinases at 10 mM but does inhibit Plk1 (Kd 61 nM)
Sigma Organic Chemistry Isophytol | 5ml | 505-32-8 | MFCD00048380
Isophytol , 5ml
About this item:
CAS #: 505-32-8
MDL #: MFCD00048380
Purity: ≥97
Molecular Weight: 296.53
UNSPSC Code: 12352100
Cayman Chemical Mulberry leaf Phytol 250g
A synthetic peptide recognized as a substrate by CaMKII (Km 12 UM) as well as protein kinase C CaMKV Raf-1 and other kinases
Cayman Chemical -AphIdIcolIn 25mg
Peptde Sequence human FABP4 amno acds 103-118 To be used n conjuncton wth Cayman s FABP4 Polyclonal Antbody (tem No 10004944) to block proten-antbody complex formaton durng mmunochemcal analyss of FABP4
Cayman Chemical -AphIdIcolIn 5mg
A non-cytotoxc nhbtor of ACC and fatty acd synthess blocks the ncorporaton of radolabeled acetate nto palmtate at 1 Ug/ml reduces malonyl-CoA levels relatvely non-toxc to varous cancer cell lnes attenuates the nhbton of feedng observed when FASN nhbtors such as cerulenn and C75 are admnstered to obese ob/ob mce
Cayman Chemical Docetaxel-d9 1mg
An OX1R antagonist (KB 39 8 nM) selective for OX1R over OX2R (KB 1995 3 nM) reduces food intake and increases resting duration in rats as well as inhibits orexin-A-induced increases in food intake at 30 mg/kg inhibits orexin-A-induced increases in grooming time in rats at 10 mg/kg increases the seizure threshold in both the MEST and 6 Hz psychomotor seizure test in mice at 30 and 3 mg/kg respectively reduces morphine-induced analgesia in the formalin test in rats at 0 5-50 nmol i c v reduces acquisition and consolidation of spatial memory in the Morris water maze in rats when administered to the dentate gyrus at 1 5-6 g
eMolecules Medchem Express / 20-Deoxyingenol / 5mg / 446275477 / HY-N0866 / / 54706-99-9 / MFCD30207875 / 332.440 / C20H28O4
Medchem Express / 20-Deoxyingenol / 5mg / 446275477 / HY-N0866 / / 54706-99-9 / MFCD30207875 / 332.440 / C20H28O4