Diterpenoids
Cayman Chemical 10-acetyl Docetaxel, Purity: ≥98%, CAS: 125354-16-7, 50 mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
Medchemexpress LLC Teprenone | 3796-63-2 | >99.8% | 50 MG
Teprenone, also known as (5E,9E,13E)-Geranylgeranylacetone, is an isomer with antiulcer activity. It induces transcriptional activation of HSP genes, which may enhance gastric mucosal defense under stress conditions. This product is for research use only.
- Isomer with antiulcer activity
- Induces transcriptional activation of HSP genes
- May increase gastric mucosal defense at conditions of stress
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Paclitaxel from semisynthetic, >=97% | 33069-62-4 | MFCD00869953 | 1MG
Paclitaxel from semisynthetic, >=97% | Purity: >=97% | Mol Wt: 853.91 | 33069-62-4 | MFCD00869953 | 1MG
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | 568-72-9 | MFCD00238692 | 20MG
Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 20MG
Abcam LDN-57444, UCH-L1 inhibitor, 25MG
MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LDN-57444, UCH-L1 inhibitor, 5MG
MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Paclitaxel S1150-1g
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 100mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Selleck Chemical LLC LDN-57444
LDN-57444 is a reversible competitive proteasome inhibitor for Uch-L1 with IC50 of 0 88 M 28-fold selectivity over isoform Uch-L3
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 500mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Medchemexpress LLC (5E,9E,13E)-teprenone | 3796-63-2 | 99.9% | 330.56 g/mol | C23H38O | 10 MG
(5E,9E,13E)-teprenone is a geranylgeranyl-derived small molecule used in research to induce heat shock proteins (HSPs) and to study gastric mucosal protection. Supplied as a high-purity reagent suitable for biochemical and cellular assays.
- High purity (99.9%) suitable for research applications.
- CAS number 3796-63-2 for unambiguous identification.
- Chemical formula C23H38O; molecular weight 330.56 g/mol.
- Supplied as a 10 mg pack for small-scale experiments.
- Recommended storage: 4°C; in solvent: -80°C (6 months) or -20°C (1 month) under nitrogen.
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 ML
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, leading to cell cycle arrest at G2/M and subsequent apoptosis. This compound demonstrates anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Demonstrates anti-cancer activity
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 500 UG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules as tracers for quantitation during the drug development process.