Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Sigma Aldrich Fine Chemicals Biosciences Formic acid European Pharmacopoeia (EP) Reference Standard | 64-18-6 | MFCD00003297 |
Formic acid European Pharmacopoeia (EP) Reference Standard | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |
eMolecules Oakwood Chemicals Formic Acid ACS Grade 2 5kg 480143864 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid ACS Grade 2 5kg 480143864 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Sigma Aldrich Fine Chemicals Biosciences FORMIC ACID, PURISS. P.A.,2.5L
Formic Acid, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98% 2.5L
Cambridge Isotope Laboratories FORMIC ACID (OD, 98%) (, 5 G, 1925-94-0
FORMIC ACID (OD, 98%) (, 5 G, 1925-94-0
TARGETMOL CHEMICALS INC BMS-561392 FORMIC ACID 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS-561392 Formic acid is a selective inhibitor of TACE and reduces TNFalpha levels.
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 50g
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 50 MG
CCT367766 formic is a potent third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. This PROTAC effectively depletes pirin protein expression at low concentrations. It demonstrates a moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM. Furthermore, it shows good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. This product serves as a valuable chemical tool for researching a protein that is currently not well understood.
- Potent third-generation PROTAC.
- Targets pirin protein degradation.
- Moderate affinity for the CRBN-DDB1 complex (IC50 = 490 nM).
- Good affinity for recombinant pirin (Kd = 55 nM) and CRBN (Kd = 120 nM).
- Useful chemical tool for pirin protein studies.
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 MG
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor (IC50 of 90 nM) that binds to both GDP-loaded and active GNP states of KRAS. It exhibits broad-spectrum binding properties and is used for studying various RAS-driven tumors, such as pancreatic cancer.
- Potent KRAS (G12D) inhibitor with IC50 of 90 nM
- Binds to GDP-loaded and active GNP states of KRAS and KRAS (G12D)
- Exhibits broad-spectrum binding properties including for KRAS WT, G12C, Q61H, G13D, and HRAS
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells (IC50 = 70 nM)
- Non-toxic to non-KRAS-dependent HEK293 cells
- Significantly inhibits ERK phosphorylation in KRAS(G12C)-driven cell lineages
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 g·mol-1 | C50H50ClN7O13 | 5 MG
CCT367766 formic is a heterobifunctional Cereblon-based PROTAC designed to induce targeted degradation of the pirin protein. It is intended for use as a chemical probe in mechanism-of-action studies and target validation, and is provided with analytical characterization data suitable for research applications.
- Cereblon-based PROTAC that degrades pirin.
- Third-generation heterobifunctional degrader for cellular target engagement studies.
- High reported purity of 98.1% for reliable experimental use.
- Characterized by LC-MS, HNMR, COA, and SDS documentation.
- Reported binding affinities: pirin Kd ≈55 nM, CRBN Kd ≈120 nM, IC50 (CRBN-DDB1) ≈490 nM.
- Available in small research quantities suitable for probe studies.
U.S. Pharmacopeia PROIONIC ACID 1.5ML AMPULES
Propionic Acid (1.5 mL/ampule; 3 ampules)U S PHARMACOPEIA mfg# 1572208
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 10KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 10KG