Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Adrixetinib TFA | C27H25F6N5O7 | 25 MG
Adrixetinib TFA is an Axl/Mer/CSF1R inhibitor. This product is supplied as an off-white to light yellow solid, with a purity of 99.82% as determined by HPLC.
- Axl/Mer/CSF1R inhibitor
- High purity (99.82% by HPLC)
- Off-white to light yellow solid appearance
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | C33H33F3N8O7 | 5 MG
Pyridostatin (TFA) | 1472611-44-1 | C33H33F3N8O7 | 5 MG
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 1mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Medchemexpress LLC Llvk tfa | 585.66 | 5 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), making it promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | 25 MG
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. It effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, oxidative phosphorylation, the IL6-JAK-STAT3 pathway, and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates the cell cycle
- Regulates DNA damage response
- Regulates oxidative phosphorylation
- Regulates the IL6-JAK-STAT3 pathway
- Regulates the ferroptosis pathway
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC D-GsMTx4 TFA | 99.9% | 4095.84 | 100 UG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This compound can inhibit mechanical allodynia and thermal hyperalgesia.
- Inhibits the mechanosensitive ion channel Piezo2.
- Inhibits intracellular calcium elevation.
- Inhibits mTOR and PI3K-Akt signaling pathways.
- Can be used in research related to mechanical stress.
- Useful for studies on chronic pain and idiopathic pulmonary fibrosis.
Medchemexpress LLC (RXR)4XB TFA | 96.6% | 5 MG
(RXR)4XB TFA is a cell-penetrating peptide that binds phosphorodiamidate morpholino oligomers (PMOs), forming peptide-conjugated PMOs (PPMOs). It improves the delivery of PMO into bacterial cells.
- Prevents biofilm formation
- Inhibits *Pseudomonas aeruginosa* with an MIC50 of 0.5 to 16 μM
- Reduces bacterial burden in mouse acute pneumonia models
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC Sar441255 TFA | 99.93% | 4866.56 (free base) | 5 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys. This product is for research use only.
- Potent unimolecular peptide
- GLP-1/GIP/GCG receptor triagonist
- Displays high potency
- Balanced activation of target receptors
- Shows positive acute glucoregulatory effects
- For research use only
Medchemexpress LLC Wrwyar-NH2 TFA | 936.07 | 1 MG
Wrwyar-NH2 (TFA) is a control peptide.
- Control peptide for wrwycr-NH2
- Targets DNA/RNA synthesis
- Involved in the cell cycle/DNA damage pathway
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 5 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
- Shipping: Room temperature in continental US
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light, under nitrogen)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light, under nitrogen)
- Solubility (H2O): 100 mg/mL (needs ultrasonic)
- Solubility (DMSO): ≥ 100 mg/mL
- Related classifications: Peptides, Peptide and derivatives, Peptides for drug delivery, Cell-penetrating peptides
- Disease areas: Infection, Anti-infection HIV
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)