Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC L-lysyl-L-cysteine trifluoroacetate | 97.8% | 477.38 g/mol | C13H21F6N3O7S | 5 MG
L-lysyl-L-cysteine trifluoroacetate is a dipeptide formed from lysine and cysteine, provided as a solid TFA salt for research use. The material is characterized by a reported purity, defined molecular formula and molecular weight, and specified storage recommendations for powder and solutions.
- Dipeptide composed of lysine and cysteine.
- Supplied as trifluoroacetate (TFA) salt in solid powder form.
- Reported purity 97.8%.
- Molecular formula C13H21F6N3O7S and molecular weight 477.38 g/mol.
- Available in small research quantities: 5 mg, 10 mg, 25 mg.
- Store sealed, away from moisture; powder: -80°C for 2 years, -20°C for 1 year; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Box5 (TFA) | 00-00-0 | 99.2% | 880.9 Da | C32H51F3N6O15S2.xC2HF3O2 | 5 MG
Box5 TFA is the trifluoroacetate salt form of a peptide antagonist of Wnt5a used in vitro to study Wnt5a-mediated signaling, calcium release, and cell migration. Supplied in small milligram vials, the material is provided with documentation to support research use.
- Trifluoroacetate salt form for improved solubility and handling.
- Potent antagonist of Wnt5a signaling for pathway studies.
- Inhibits Wnt5a-mediated calcium release and cell migration.
- High purity approximately 99.2% for consistent results.
- Supplied in small milligram sizes suitable for in vitro experiments.
- COA and SDS available for quality and safety verification.
Medchemexpress LLC Tamapin TFA | 98.8% | 3458.11 | 5 MG
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. It is a selective blocker of SK2 (Potassium Channel) and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus).
- Targets small conductance Ca(2+)-activated K(+) (SK) channels
- Selective blocker of SK2 (Potassium Channel)
- Inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus
Medchemexpress LLC 5-fam-ahx-ll-37 tfa | 98.06% | 4964.72 (free acid) | 1 MG
5-FAM-Ahx-LL-37 TFA is a 5-FAM-labeled human LL-37, a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid. This peptide exhibits a broad spectrum of antimicrobial activity.
- Appears as a solid
- Sequence is {5-FAM-Ahx}-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-R-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
- Ships at room temperature in continental US
- Store powder sealed away from moisture at -80°C for 2 years or -20°C for 1 year
- Store in solvent sealed away from moisture at -80°C for 6 months or -20°C for 1 month
- Soluble in H2O at 16.67 mg/mL (requires ultrasonic assistance)
- Classified as an antimicrobial peptide
Medchemexpress LLC Dendrotoxin K TFA | 119128-61-9 | 6559.66 | 500 UG
Dendrotoxin K functions as a Kv1.1 channel blocker. It plays a role in determining glutamate release within CA3 neurons by controlling the presynaptic spike waveform in a time-dependent manner.
- Acts as a Kv1.1 channel blocker.
- Influences glutamate release in CA3 neurons.
- Regulates the presynaptic spike waveform in a time-dependent manner.
- Intended for research use only.
Medchemexpress LLC Forigerimod trifluoroacetate | 00-00-0 | 99.9% | C117H181N34O32PS·xC2HF3O2 | 5 MG
Forigerimod TFA is a 21-amino-acid peptide fragment supplied as the trifluoroacetate salt. It acts as a CD4 T-cell modulator and has been used in research on autophagy and autoimmune disorders, including systemic lupus erythematosus. Supplied as a powder with high listed purity, it is intended for research use in cellular and immunology studies.
- 21-amino-acid peptide, TFA salt
- High purity suitable for research (listed 99.88%)
- Soluble in DMSO and water at 100 mg/mL with sonication
- Powder storage: -80°C (2 years) or -20°C (1 year)
- In solvent storage: -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC FRETS-VWF73 (TFA) | 96.8% | 9340.61 | 500 UG
FRETS-VWF73 (TFA) is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay. This peptide is utilized as a predictive tool for thrombotic thrombocytopenic purpura, offering a valuable resource for research and diagnostic applications.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Used as a predictive tool for thrombotic thrombocytopenic purpura
- Excitation at 340 nm; emission at 450 nm
Medchemexpress LLC Thymotrinan | 00-00-0 | MFCD00237286 | 98.7% | 531.48 g·mol⁻¹ | C18H32F3N7O8 | 5 MG
Thymotrinan TFA is the trifluoroacetate (TFA) salt of a biologically active fragment of the thymus hormone thymopoietin. It exhibits immunomodulatory activity similar to TP5, affecting both humoral and cellular immune responses, and is supplied as a white to off-white solid for research use. Manufacturer storage and handling guidelines should be followed.