Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC W146 trifluoroacetate | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 25 MG
W146 trifluoroacetate is a research-grade selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1). Supplied as the trifluoroacetate salt in a white to off-white solid form, it has an EC50 of 398 nM, a molecular weight of 456.39 g/mol, and is typically supplied at high purity for in vitro pharmacology and receptor signaling studies. Not for human or clinical use.
- Selective S1PR1 antagonist with EC50 398 nM
- Provided as trifluoroacetate salt for stability
- High purity suitable for biochemical assays
- White to off-white solid for easy handling
- Intended for in vitro pharmacology and receptor signaling studies
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo25G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo25G
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 99.9% | 1188.4 g/mol | C56H85N17O12 · x C2HF3O2 | 5 MG
Lys-bradykinin trifluoroacetate is the trifluoroacetic acid (TFA) salt form of the peptide Lys-Bradykinin (kallidin 380-389). It is supplied as a purified powder for research applications where it serves as a ligand for kallidin and bradykinin receptors. Reported purity is 99.85% and the free-base molecular weight is 1188.38 g/mol.
- TFA salt of Lys-Bradykinin peptide.
- High purity (99.85%).
- Provided as a solid powder suitable for dissolution in common solvents.
- Recommended storage: sealed, protected from moisture and light; powder stable at -80°C for up to 2 years.
- Intended for research use as a ligand in receptor binding or signaling studies.
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 1KG
Trifluoroacetic acid, 76-05-1, MFCD00004169, 1KG
Cambridge Isotope Laboratories Trifluoroacetic Acid-D (D, 99.5%), 10 G Amp, 599-00-8
This item has a minimum order quantity of 2 per supplier requirements
Trifluoroacetic Acid-D (D, 99.5%), 10 G Amp, 599-00-8
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 1mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology