Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Bibo 3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g/mol | C31H36F3N7O5 | 5 MG
BIBO3304 (trifluoroacetate) is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research tool to probe NPY1R-mediated signaling in pharmacology and neuroscience studies. It is supplied as a high-purity solid and is characterized for receptor binding and in vitro functional assays.
- High potency and selectivity for the NPY Y1 receptor.
- Suitable for in vitro receptor binding and functional assays.
- High reported purity for reproducible experimental results.
- Available as a solid and as a DMSO solution for assay convenience.
- Well characterized with supporting chemical identifiers and structural data.
Hampton Research 30% W/V POLYETHYLENE GL 200ML
HR2-609/30% w/v Polyethylene glycol 20,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Medchemexpress LLC dTAGV-1 TFA | 2624313-15-9 | 99.9% | C70H91F3N6O16S | 1 MG
dTAGV-1 TFA is a potent and selective PROTAC degrader targeting FKBP12F36V-tagged proteins. It is capable of inducing degradation of FKBP12F36V-Nluc both in vitro in 293FT cells and in vivo in animal models.
- Potent and selective degrader of FKBP12F36V-tagged proteins.
- Induces degradation of FKBP12F36V-Nluc in vivo.
- Effective in 293FT cells.
- Reduces bioluminescent signal in animal models.
Medchemexpress LLC TP-5801 TFA | 99.6% | 641.48 | 5 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with anti-tumor activity.
- TNK1 inhibitor with an IC50 of 1.40 nM.
- Inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth.
- Demonstrates efficacy in mouse survival models.
- Capable of inhibiting localized tumor growth in vivo.
- For research use only.
TARGETMOL CHEMICALS INC CAMIZESTRANT TFA 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Camizestrant TFA (AZD-9833 TFA) is a potent and orally active antagonist of estrogen receptor (ER).
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 4X100G
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 4X100G
Medchemexpress LLC Eda-da tfa | 87156-01-2 | 95.0% | 298.22 | 5 MG
EDA-DA is a N-terminally tagged dipeptide probe used to label Peptidoglycan (PG) of bacteria. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- N-terminally tagged dipeptide probe
- Labels peptidoglycan of bacteria
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC BIBP3226 TFA | 1068148-47-9 | 99.3% | 587.59 | 5 MG
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. It has been observed to display an anxiogenic-like effect.
- Potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist.
- Ki values of 1.1 nM for rNPY Y1, 79 nM for hNPFF2, and 108 nM for rNPFF.
- Induces an anxiogenic-like effect at higher doses in vivo.
- Available in 5 mg quantity.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo25G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo25G
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Medchemexpress LLC Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID-D 10X0.75
NC3803001 TRIFLUOROACETIC ACID-D 10X0.75
VWR International Trifluoroacetic acid ≥99.8% | 76-05-1 | MFCD00004169 | 1l
Trifluoroacetic acid ≥99.8% | 76-05-1 | MFCD00004169 | 1l