Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Homoglutathione TFA | 95.0% | 435.37 | C13H20F3N3O8S | 5mg
Homoglutathione (TFA) is a biological molecule
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC LY117018 TFA 25mg | 2390041-98-0 | 25 MG
LY117018 TFA is a raloxifene analog and a selective estrogen receptor modulator (SERM) reported to exert antiproliferative effects on breast cancer cell lines. Supplied as a trifluoroacetate salt, the compound is provided as a small-scale research reagent for in vitro studies.
- Selective estrogen receptor modulator activity.
- Reported antiproliferative effects on breast cancer cell lines.
- Supplied as a trifluoroacetate salt for improved handling.
- Available in milligram-scale quantities for research use.
- Chemical formula C29H26F3NO6S; molecular weight 573.58 g/mol.
Medchemexpress LLC Ecallantide (DX-88) trifluoroacetate | 00-00-0 | 7053.81 g/mol (free base) | C305H442N88O91S8 · xC2HF3O2 | 5 MG
Ecallantide TFA is a recombinant plasma kallikrein inhibitor supplied as the trifluoroacetate salt for research use. It inhibits kallikrein-mediated formation of bradykinin and is used in laboratory studies of angioedema and bradykinin-related pathways. Provided in defined small-scale packages for analytical and preclinical research; not for human use.
- Specific recombinant plasma kallikrein inhibitor.
- Trifluoroacetate salt formulation for stability and handling.
- Available in small, defined package sizes suitable for research.
- Characterized molecular weight and molecular formula provided.
- Intended for research use only; not for clinical or human use.
- Applicable to studies of bradykinin-mediated signaling and angioedema models.
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
eMolecules Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722