Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 1 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe. It works by inhibiting EBNA1 homodimer formation, which selectively inhibits EBV+ tumor growth. It shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based, EBNA1 targeting fluorescent probe
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Molecular weight: 1961.83 (free base)
- Appearance: Solid
- Color: Purple to purplish red
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC aStAx-35R TFA | 99.1% | 2392.86 | 1 MG
aStAx-35R TFA is a stapled peptide that functions as an antagonist of the nuclear form of β-catenin, thereby inhibiting Wnt signaling. It competitively prevents the binding of β-catenin to TCF4 and selectively induces growth inhibition in Wnt-dependent cancer cells.
- Directly targets and antagonizes the nuclear form of β-catenin.
- Effectively inhibits the Wnt signaling pathway.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition in cancer cells dependent on Wnt signaling.
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 1 MG
Tpp-CAQK TFA is an engineered mitochondrial compound that can bind to mitochondria, enabling the construction of Mito-Tpp-CAQK TFA with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Can bind to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances macrophage phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in mice after spinal cord injury
- For research use only
Medchemexpress LLC LL-37, human TFA | 154947-66-7 | 100.0% | 4493.26 | 5 MG
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. It demonstrates a broad spectrum of antimicrobial activity.
- Exhibits broad-spectrum antimicrobial activity.
- May help protect the cornea from infection.
- Modulates wound healing.
Medchemexpress LLC Rsm3 Tfa | 98.8% | 3049.66 | 1 MG
This product is a stapled peptide that acts as an inhibitor of METTL3-METTL14, with a Kd of 3.10 μM. It has been shown to inhibit tumor growth and induce cell apoptosis, making it useful for cancer research.
- It is a stapled peptide.
- It is a METTL3-METTL14 inhibitor.
- It inhibits tumor growth.
- It induces cell apoptosis.
- It is suitable for cancer research.
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | 98.74% | 4907.48 | 5 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. This compound is used in antidiabetic research and is for research use only. It is orally active and can also be administered by injection.
- Dual GIP and GLP-1 receptor agonist
- Orally active
- Can be administered by injection
- Suitable for antidiabetic research
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 5 MG
NN1177 TFA (NNC9204-1177 TFA) is a long-acting GLP-1/glucagon receptor co-agonist. This compound is known to induce dose-dependent body weight loss in diet-induced obese mice and improves glucose tolerance. It has also been shown to reduce liver fat and relevant inflammatory and fibrosis biomarkers in NASH models.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces body weight loss
- Improves glucose tolerance
- Reduces liver fat
- Reduces inflammatory and fibrosis relevant biomarkers
- For research use only
Medchemexpress LLC Ppack TFA | 157379-44-7 | 99.8% | 5 MG
PPACK TFA is a potent, selective, and irreversible thrombin inhibitor supplied as the trifluoroacetate (TFA) salt. It is used as an anticoagulant alternative for blood gas and whole-blood electrolyte analyses and inhibits plasminogen activator (rt-PA) binding to plasma protease inhibitors.
- Irreversible thrombin inhibitor for anticoagulant applications.
- Supplied as the trifluoroacetate salt for stability and handling.
- High analytical purity (99.8%).
- Suitable for blood gas and whole-blood electrolyte analyses.
- Available in a 5 mg research-size vial.
- CAS number: 157379-44-7.
Medchemexpress LLC D-phenylalanyl-prolyl-arginyl chloromethyl ketone trifluoroacetate | 157379-44-7 | 99.8% | 1 ML
PPACK TFA is a potent, selective, irreversible thrombin inhibitor supplied as a 10 mM solution in DMSO (1 mL). It is used as an anticoagulant and a biochemical tool to inhibit thrombin activity in blood-sample handling and enzymatic assays.
- Potent, selective, irreversible thrombin inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity for reproducible experimental results.
- Molecular weight 564.99 g/mol; CAS 157379-44-7.
- Store sealed and away from moisture; follow storage instructions for solution and powder.
Medchemexpress LLC Dota-octreotide tfa | 99.3% | 1519.66 | 1 MG
DOTA-Octreotide TFA is composed of the chelator DOTA and Octreotide (HY-P0036). It is utilized for cancer research through its combination with radioactive elements and can be employed for the synthesis and research of Radionuclide-Drug Conjugates (RDCs). Its molecular formula is C67H93F3N14O19S2 with a molecular weight of 1519.66. It appears as a white to off-white solid.
- Used for cancer research
- Combines with radioactive elements
- Can be used for synthesis and research of radionuclide-drug conjugates (RDCs)
- Soluble in H2O at ≥ 50 mg/mL (32.90 mM)
- Powder stable for 2 years at -80°C and 1 year at -20°C
- Solution stable for 6 months at -80°C and 1 month at -20°C
Medchemexpress LLC Astressin 2B TFA | 99.54% | 4041.69 | 500 UG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. It also reverses the protective effects of Urocortin 1 and attenuates stress-induced anxiety-related behaviors. This product is a valuable tool for investigating the intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist (IC50=0.57 nM).
- Blood-brain barrier-impermeable.
- Exacerbates indomethacin-induced hemorrhagic intestinal injury.
- Reverses protective effects of urocortin 1.
- Attenuates stress-induced anxiety-related behaviors.
- Valuable tool for studying CRFR2 intestinal protective mechanisms.
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 50 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM. It demonstrates significant anti-tumor activity both in vitro and in vivo. This compound is stable under recommended storage conditions and is for research use only.
- Inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth
- Inhibits TNK1-dependent L540 cell growth at low nanomolar levels
- Shows efficacy in mouse survival models with no observed toxicity
- Reduces localized tumor growth and phospho-STAT3 in xenograft models