Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Apexbio Technology LLC Pyrophosphatase Inorganic (E. coli) 10 units
Pyrophosphatase Inorganic (E coli) purified from recombinant E coli strain carrying the E coli inorganic pyrophosphatase gene Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that catalyzes the hydrolysis of inorganic pyrophosphate into orthophosphate
Apexbio Technology LLC 2X hyperfusion plus master mix 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Hyperfusion Plus DNA Polymerase exhibits both 5 to 3 polymerase activity and 3 to 5 exonuclease (proofreading) activity producing blunt-ended amplification products rather than A-tailed ends (commonly produced by Taq polymerase) Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo100G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo100G
Apexbio Technology LLC DTP3 TFA 1809784-29-9 (free-base) 25mg
DTP3 TFA is a small-molecule inhibitor targeting the GADD45 /MKK7 protein-protein interaction complex It is designed to disrupt this interaction thereby modulating downstream NF- B signaling involved in tumor cell survival DTP3 TFA exerts its biological activity primarily by binding directly to MKK7 (KD 64 81 nM) inducing conformational changes that dissociate GADD45 from MKK7 resulting in activation of JNK signaling In cell-based studies DTP3 TFA selectively inhibits proliferation of cancer cell lines with elevated GADD45 expression Based on these pharmacological properties DTP3 TFA holds research potential in the study and therapeutic intervention of cancers including multiple myeloma via disruption of GADD45 /MKK7 signaling
TARGETMOL CHEMICALS INC Elarofiban TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease. Purity 100%
![eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502158414.JPG-250.jpg)
eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g
Medchem Express | Azosemide | 10mg | 495799592 | HY-107321 | 27589-33-9 | MFCD00867321 | 370.830 | C12H11ClN6O2S2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Selleck Chemical LLC Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable competitive and irreversible inhibitor of enzyme caspase-9 which helps in cell survival
Waters Corp Proteomics Training Standards, Kit
Waters Corporation Proteomics Training Standards, Kit
Medchemexpress LLC Bio-AMS TFA | 00-00-0 | 98.0% | 685.65 g/mol | C22H30F3N9O9S2 | 5 MG
Bio-AMS TFA is a bacterial biotin protein ligase inhibitor supplied as the trifluoroacetate (TFA) salt for research use. It shows selective activity against Mycobacterium tuberculosis and disrupts fatty acid and lipid biosynthesis.
- Potent biotin protein ligase inhibition.
- Selective activity against Mycobacterium tuberculosis.
- Provided as the TFA salt to aid handling and solubility.
- High purity: 98.0%.
- Molecular weight 685.65 g/mol; formula C22H30F3N9O9S2.
- Available in small research pack sizes, including 5 mg.
- Suitable for biochemical and microbiology research applications.
Medchemexpress LLC 6bK (TFA) | 1774353-12-6 | MFCD30182289 | 99.4% | 871.94 g/mol | C43H56F3N7O9 | 5 MG
6bK TFA is a potent, selective insulin-degrading enzyme (IDE) inhibitor used in preclinical research to study insulin metabolism and glucose tolerance. It shows an in vitro IC50 of approximately 50 nM and has been reported to increase circulating insulin and improve oral glucose tolerance in high-fat-fed mice.
- Potent IDE inhibition (IC50 ≈ 50 nM).
- Selective activity for insulin-degrading enzyme.
- High purity (≈99.4%).
- Available as solid and DMSO solution in multiple pack sizes.
- Supplied with analytical documents (COA, HPLC, LCMS).
- Recommended storage: solid -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC YKL-5-124 trifluoroacetate | 2748220-93-9 | 99.7% | 629.63 | C30H34F3N7O5 | 10 MM x 1 ML
YKL-5-124 TFA is the trifluoroacetate salt of a potent, selective, irreversible, covalent cyclin-dependent kinase 7 (CDK7) inhibitor. Supplied as a 10 mM solution in DMSO (1 mL), it is intended for research use in biochemical and cellular assays and is reported to induce cell-cycle arrest and inhibit E2F-driven gene expression while minimally affecting RNA polymerase II phosphorylation.
- Potent, selective CDK7 inhibition
- Irreversible covalent mechanism of action
- Supplied as a 10 mM solution in DMSO, 1 mL vial
- High purity suitable for biochemical and cellular studies
- Molecular formula and mass provided for identification
Medchemexpress LLC Homoglutathione TFA | 95.0% | 435.37 | C13H20F3N3O8S | 5mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC CH-0793076 TFA (TP3076 TFA) | 2740278-76-4 | 98.7% | 572.53 g·mol⁻¹ | C28H27F3N4O6 | 5 MG
CH-0793076 TFA is a camptothecin-like hexacyclic analog and the active metabolite of TP300 that functions as a DNA topoisomerase I inhibitor. It is supplied as a trifluoroacetate salt for research use and has demonstrated antiproliferative activity, including activity against cells expressing BCRP.
- Inhibits DNA topoisomerase I (reported IC50 ≈ 2.3 μM).
- Active metabolite of TP300.
- Demonstrates antiproliferative activity in cellular assays.
- Provided as a trifluoroacetate salt suitable for biochemical studies.
- Molecular weight 572.53 g·mol⁻¹; chemical formula C28H27F3N4O6.
Medchemexpress LLC Lys-bradykinin TFA | 00-00-0 | 99.9% | 1188.38 g/mol (free base) | C56H85N17O12 · xC2HF3O2 | 25 MG
Lys-bradykinin TFA is the trifluoroacetate salt form of the decapeptide kallidin (Lys-bradykinin). It is used as a research reagent and acts as a ligand for kallidin and bradykinin receptors, supporting studies in vascular regulation, inflammation, and pain signaling.
- TFA salt form of lys-bradykinin (kallidin).
- High purity (≈99.85%).
- Molecular weight 1188.38 g/mol (free base).
- Provided in small quantities suitable for biochemical assays; 25 mg size available.
- Intended for receptor binding and vascular biology research applications.