Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC SETD2-IN-1 (TFA) | 2411759-92-5 | 97.2% | 514.51 | 100 MG
EZM0414 TFA is the TFA salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, with an IC50 of 18 nM in a biochemical assay and 34 nM in a cellular assay. This product is intended for research related to relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active inhibitor of SETD2.
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines.
- Demonstrated robust tumor growth regressions in xenograft models.
- Correlated with reductions in intratumoral H3K36me3 levels.
- Well-tolerated in animal models.
- Exhibits high oral bioavailability in rats and mice.
eMolecules 76045-93-7 | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC Fti-276 trifluoroacetate | 1217471-51-6 | 98.0% | 547.6 g/mol | C23H28F3N3O5S2 | 10 MG
FTI-276 trifluoroacetate is the trifluoroacetate salt of a small-molecule inhibitor of protein farnesyl transferase. It is provided as a solid for research use and exhibits sub-nanomolar activity against both Plasmodium falciparum and human PFT, making it suitable for biochemical and antiparasitic research applications.
- Potent protein farnesyl transferase inhibition at sub-nanomolar concentrations.
- Provided as the trifluoroacetate (TFA) salt to aid handling and formulation.
- High reported purity, approximately 98%.
- Supplied in small, research-ready quantities suitable for assay development.
- Characterized by published chemical identifiers for unambiguous compound identification.
Medchemexpress LLC FRETS-VWF73 TFA | 97.4% | 9340.61 | 5 MG
FRETS-VWF73 TFA is a 73-amino-acid peptide that functions as a fluorogenic substrate for ADAMTS13 assay.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Excitation at 340 nm
- Emission at 450 nm
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
Medchemexpress LLC VMIP-II (1-21) TFA | 5 MG
vMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. It interacts broadly with CC and CXC chemokine receptors, inhibiting CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM). This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C108H169N33O27S.xC2HF3O2
- Sequence: Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro
- Target: CXCR
- Pathway: GPCR/G protein; immunology/inflammation
Medchemexpress LLC Iberiotoxin TFA | 99.4% | 4230.85 | 1 MG
Iberiotoxin (TFA) is a potent and selective inhibitor of high conductance Ca2+-activated K+ channels. This compound demonstrates high affinity for its target with a Kd of approximately 1 nM, and it specifically targets these channels without affecting other types of voltage-dependent ion channels.
- Selective inhibitor of high conductance Ca2+-activated K+ channels.
- High affinity with a Kd of ~1 nM.
- Does not block other types of voltage-dependent ion channels.
Medchemexpress LLC Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Apexbio Technology LLC Pyrophosphatase Inorganic (E. coli) 10 units
Pyrophosphatase Inorganic (E coli) purified from recombinant E coli strain carrying the E coli inorganic pyrophosphatase gene Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that catalyzes the hydrolysis of inorganic pyrophosphate into orthophosphate
Medchemexpress LLC Valylleucine TFA | 27530-02-5 | 99.3% | 344.33 | 25 MG
Valylleucine TFA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. It can be used for protein interaction, functional analysis, and epitope screening, especially in agent research and development.
- Polypeptide
- Used in peptide screening
- Pools active peptides by immunoassay
- Supports protein interaction studies
- Enables functional analysis
- Facilitates epitope screening
- Applicable in agent research and development
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic Acid | CAS 76-05-1
Trifluoroacetic Acid | Purity: >=99.0% | M. W.: 114.02 | 76-05-1 | 200-929-3
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 50 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM. It demonstrates significant anti-tumor activity both in vitro and in vivo. This compound is stable under recommended storage conditions and is for research use only.
- Inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth
- Inhibits TNK1-dependent L540 cell growth at low nanomolar levels
- Shows efficacy in mouse survival models with no observed toxicity
- Reduces localized tumor growth and phospho-STAT3 in xenograft models