Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC LY117018 TFA 25mg | 2390041-98-0 | 25 MG
LY117018 TFA is a raloxifene analog and a selective estrogen receptor modulator (SERM) reported to exert antiproliferative effects on breast cancer cell lines. Supplied as a trifluoroacetate salt, the compound is provided as a small-scale research reagent for in vitro studies.
- Selective estrogen receptor modulator activity.
- Reported antiproliferative effects on breast cancer cell lines.
- Supplied as a trifluoroacetate salt for improved handling.
- Available in milligram-scale quantities for research use.
- Chemical formula C29H26F3NO6S; molecular weight 573.58 g/mol.
Medchemexpress LLC Retatrutide TFA 10mg
Retatrutide, (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity. 10mg
Medchemexpress LLC LY117018 TFA 5mg | 2390041-98-0 | 573.58 | C29H26F3NO6S | 5 MG
LY117018 TFA is the trifluoroacetic acid salt of LY117018, a raloxifene analog and selective estrogen receptor modulator reported to exert antiproliferative effects on breast cancer cell lines. It is provided as a research reagent for in vitro and in vivo studies of estrogen receptor signaling and related pathways.
- Selective estrogen receptor modulator with reported antiproliferative activity.
- Soluble in DMSO up to 100 mg/mL; sonication may be required.
- In vivo formulations reported with solubility ≈5 mg/mL using common co-solvent systems.
- Recommended storage: solid sealed and kept away from moisture; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular formula C29H26F3NO6S; molecular weight 573.58.
Cambridge Isotope Laboratories Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Apexbio Technology LLC Pyrophosphatase Inorganic (E. coli) 10 units
Pyrophosphatase Inorganic (E coli) purified from recombinant E coli strain carrying the E coli inorganic pyrophosphatase gene Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that catalyzes the hydrolysis of inorganic pyrophosphate into orthophosphate
eMolecules Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
