Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 99.9% | 1188.4 g/mol | C56H85N17O12 · x C2HF3O2 | 5 MG
Lys-bradykinin trifluoroacetate is the trifluoroacetic acid (TFA) salt form of the peptide Lys-Bradykinin (kallidin 380-389). It is supplied as a purified powder for research applications where it serves as a ligand for kallidin and bradykinin receptors. Reported purity is 99.85% and the free-base molecular weight is 1188.38 g/mol.
- TFA salt of Lys-Bradykinin peptide.
- High purity (99.85%).
- Provided as a solid powder suitable for dissolution in common solvents.
- Recommended storage: sealed, protected from moisture and light; powder stable at -80°C for up to 2 years.
- Intended for research use as a ligand in receptor binding or signaling studies.
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397365.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue.
- Acts as a GnRH receptor agonist.
Medchemexpress LLC ACV Tripeptide TFA | 477.45 | 25 MG
ACV Tripeptide TFA is a tripeptide that serves as the initial dedicated intermediate in the biosynthetic pathway leading to penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is nonribosomally synthesized by the ACV synthetase (ACVS) enzyme, encoded by the 11 kb *pchAB* gene, and can be used for the biosynthesis of β-lactam antibiotics. This tripeptide contains the unusual amino acid α-aminoadipic acid (α-AAA), along with L-cysteine and D-valine.
- Tripeptide
- Initial intermediate in β-lactam biosynthesis
- Synthesized by ACV synthetase (ACVS) enzyme
- Contains α-aminoadipic acid (α-AAA), L-cysteine, and D-valine
- Molecular weight: 477.45
- Formula: C16H26F3N3O8S
- Appearance: Solid
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 25 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue. It acts as a GnRH receptor agonist.
- Luteinizing-hormone-releasing hormone (LHRH) analogue
- GnRH receptor agonist
Medchemexpress LLC Gln-AMS TFA | 99.9% | 588.47 | 100 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor, specifically inhibiting glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Inhibits glutaminyl-tRNA synthetase (GlnRS)
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- White to off-white solid
- Purity of 99.85%
- Soluble in DMSO at 100 mg/mL
- Store at -20°C under nitrogen
Medchemexpress LLC DEC-RVRK-CMK TFA | 96.1% | 744.41 | 1 MG
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position. It is for research use only.
- Peptide-based CMK inhibitor
- Targets and inactivates secreted soluble kexin (Kex2)
- Ki of 8.45 μM against ssKex2
- Inhibits yeast enzyme Kex2 (kexin, EC 3.4.21.61)
- Calcium-dependent transmembrane protease
- Useful for studying binding mechanisms and substrate selectivity
![Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438226-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG
AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. It potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.
- Potentiates TRPV1 channels activation by protons
- Drives reflectory inhibition of thermogenesis and tail-skin vasoconstriction
- Potently blocks channel activation by capsaicin
Medchemexpress LLC PBX-7011 TFA | 3003834-30-5 | 98.6% | 561.46 | 1 ML
PBX-7011 TFA is a derivative of camptothecin that inhibits the expression of cancer-related survival genes and degrades DDX5 proteins.
- Inhibits expression of cancer-related survival genes (DDX5, Survivin, Mcl-1, and XIAP in FaDu cells).
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G