Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Difopein TFA | 96.30% | 6387.17 (free acid) | 5 MG
Difopein TFA is a specific and competitive inhibitor of the 14-3-3 protein, a highly conserved eukaryotic regulatory molecule. It functions by blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. This compound is not cell permeable and induces apoptosis, enhancing the ability of Cisplatin to kill cells.
- Specific and competitive inhibitor of 14-3-3 protein
- Blocks 14-3-3 from binding to target proteins
- Inhibits 14-3-3/ligand interactions
- Induces apoptosis
- Enhances cisplatin's ability to kill cells
- Target: 14-3-3 protein
- Soluble in DMSO at ≥ 100 mg/mL
- In vivo soluble at ≥ 2.5 mg/mL with specific protocol
- Recommended storage for powder: -80°C for 2 years; -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC WP9QY TFA | 99.4% | 1340.40 | 1 MG
WP9QY, a TNF-a Antagonist, is a biologically active peptide.
- This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I.
- It prevents interactions of TNF with its receptor.
- This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.
Medchemexpress LLC KLD-12 TFA | 95.22% | 1467.79 | 5 MG
KLD-12 TFA is the TFA salt form of KLD-12, a 12-residue self-assembling peptide. It is used in tissue engineering and, when combined with SDF-1 self-assembled polypeptide, enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). The hydrogel form can fill full-thickness osteochondral defects in situ and improve cartilage repair. In vivo, it promotes bone regeneration at the fracture site in a dose-dependent manner.
- Enhances chondrogenic differentiation of bone marrow stromal cells
- Forms self-assembled polypeptide with SDF-1
- Improves survival of bone marrow stromal cells
- Promotes osteogenic differentiation of bone marrow stromal cells and cell migration via Wnt/β-catenin pathway
- Promotes bone regeneration at the fracture site
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 50 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. It is for research use only and not sold to patients.
- Functions as a selective PAR1 agonist.
- Stimulates concentration-dependent increases in intracellular calcium.
- Modulates E-cadherin and vimentin expression in SW620 cells.
- Induces edema in rat paw models.
- Stimulates Evans blue extravasation in various mouse tissues.
- Exhibits both contraction and relaxation effects.
Medchemexpress LLC TAT peptide TFA | 99.8% | 1735.93 | 25 MG
TAT peptide (TFA) is a cell penetrating peptide (GRKKRRQRRRPQ) derived from the trans-activating transcriptional activator (Tat) from HIV-1. It has been studied in functionalized hybrid nanoparticles for magnetic enrichment and optical detection in cell separation and rapid cell labelling, demonstrating good biocompatibility.
- Derived from trans-activating transcriptional activator (Tat) from HIV-1
- Cell penetrating peptide (GRKKRRQRRRPQ)
- Used in functionalized hybrid nanoparticles for cell separation
- Used in rapid cell labelling
- Shows good biocompatibility
- For research use only
Medchemexpress LLC GRGDSPC TFA | 99.2% | 804.75 | 5 MG
GRGDSPC TFA is a 7-amino acid thiolated cell adhesion peptide. It is utilized in conjugation reactions with acrylated dextran to regulate the interactions of human mesenchymal stem cells (hMSCs) with photocrosslinkable hydrogels.
- Thiolated cell adhesion peptide
- Composed of 7 amino acids
- Regulates human mesenchymal stem cell interactions
- Suitable for research applications
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Medchemexpress LLC Balixafortide TFA | 99.89% | 1978.16 | 50 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. It shows 1000-fold selectivity for CXCR4 compared to a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. It is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent and exhibits anti-cancer effects.
- Potent, selective, well-tolerated peptidic CXCR4 antagonist
- High selectivity for CXCR4 (1000-fold over CXCR7)
- Blocks β-arrestin recruitment and calcium flux
- Potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Anti-cancer effects
- Optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.7% | 871.94 | 25 MG
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It increases circulating insulin in high-fat-fed mice and enhances glucose tolerance to oral glucose, especially in high-fat-fed mice.
- Potent and selective insulin degrading enzyme (IDE) inhibitor
- IC50 value of 50 nM
- Increases circulating insulin in high-fat-fed mice
- Enhances glucose tolerance to oral glucose
- Suitable for type 2 diabetes research
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 ML
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. It inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM and does not influence RAD51 binding to ssDNA.
- Potent and selective RAD51-mediated D-loop formation inhibitor
- IC50 of 11.1 μM for D-loop formation
- Inhibits homologous recombination (HR) activity in human cells
- Does not influence RAD51 binding to ssDNA
- Stabilizes nucleoprotein filaments in a nonfunctional state
- Shielded from pathways promoting single-strand annealing
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC PF15 (TFA) | 99.7% | C46H50F3N13O8 | 25 MG
PF15 TFA is a PROTAC that connects ligands for FLT3 kinase and CRBN. It is a highly selective FLT3-ITD degrader with a DC50 of 76.7 nM. It significantly inhibits the proliferation of FLT3-ITD-positive cells and can down-regulate the phosphorylation of FLT3 and STAT5. It also inhibits tumor growth in mouse models and can be used in the study of leukemia.
- Connects ligands for FLT3 kinase and CRBN
- Highly selective FLT3-ITD degrader
- Has a DC50 of 76.7 nM
- Inhibits proliferation of FLT3-ITD-positive cells
- Down-regulates the phosphorylation of FLT3 and STAT5
- Inhibits tumor growth in mouse models
- Used in the study of leukemia