Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
![Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | C25H20F3N5O6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | C25H20F3N5O6 | 5 MG
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in gastric cancer models
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Regulates oxidative phosphorylation
- Regulates IL6-JAK-STAT3 pathway
- Regulates ferroptosis pathway
Medchemexpress LLC Astressin 2B TFA | 99.54% | 4041.69 | 500 UG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. It also reverses the protective effects of Urocortin 1 and attenuates stress-induced anxiety-related behaviors. This product is a valuable tool for investigating the intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist (IC50=0.57 nM).
- Blood-brain barrier-impermeable.
- Exacerbates indomethacin-induced hemorrhagic intestinal injury.
- Reverses protective effects of urocortin 1.
- Attenuates stress-induced anxiety-related behaviors.
- Valuable tool for studying CRFR2 intestinal protective mechanisms.
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 25 MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects.
- Induces mitochondrial alterations
- ROS generation
- Intracellular Ca+ accumulation
- Calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells through immunogenic cell death
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 1 MG
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Tetrapeptide
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Lysylcysteine TFA | 97.8% | 477.38 | 25 MG
Lysylcysteine TFA (L-Lysyl-L-cysteine TFA) is a dipeptide composed of lysine and cysteine, intended for research use only. It is not for human use. This product is provided as a white to off-white solid with a high purity of 97.84% and a molecular weight of 477.38. It is shipped at room temperature in the continental US and requires sealed storage away from moisture.
- High purity: 97.84%
- Molecular weight: 477.38
- Dipeptide composed of lysine and cysteine
- Appearance: White to off-white solid
- Sequence: Lys-Cys
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Liraglutide TFA | 204656-20-2 | 99.6% | 3751.20 (free base) | 1 MG
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). It can activate GLP-1, leading to insulin release in the presence of increased glucose concentration, and also reduces glucagon secretion in a glucose-dependent manner. It can be used in research on type 2 diabetes.
- Activates GLP-1 receptor
- Leads to insulin release
- Reduces glucagon secretion
- Suitable for type 2 diabetes research
Medchemexpress LLC RSM3 TFA | 98.83% | 3049.66 | 5 MG
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with a Kd of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA can be used for the study of cancer.
- Inhibits tumor growth
- Induces cell apoptosis
- Used for the study of cancer
- Stapled peptide
- METTL3-METTL14 inhibitor
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 1 MG
Tpp-CAQK TFA is an engineered mitochondrial compound that can bind to mitochondria, enabling the construction of Mito-Tpp-CAQK TFA with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Can bind to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances macrophage phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in mice after spinal cord injury
- For research use only
Medchemexpress LLC Ss47 Tfa | 2636072-62-1 | 99.88% | 1067.09 | 1 MG
SS47 TFA is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated HPK1 degradation. This significantly improves in vivo antitumor efficacy in BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies. SS47 (TFA) is also a click chemistry reagent with an Alkyne group, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- PROTAC-based HPK1 degrader
- Facilitates proteasome-mediated HPK1 degradation
- Enhances in vivo antitumor efficacy in BCMA CAR-T cell research
- Targets HPK1, an immunosuppressive regulatory kinase
- Click chemistry reagent with alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Mifamurtide (TFA) | 98.0% | 1351.52 | 1 MG
Mifamurtide TFA (MTP-PE TFA) is an analog of the muramyl dipeptide (MDP) that functions as a nonspecific immunomodulator by stimulating the immune response, activating macrophages and monocytes. It is a specific ligand for NOD2 and acts as an insulin sensitizer, with potential applications in rare disease and osteosarcoma research.
- Induces reduction of MG63 cell numbers when co-cultured with macrophages.
- Increases M1 polarization marker iNOS and M2 polarization marker CD206 mRNAs.
- Increases pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines.
- Activates macrophages and monocytes, leading to upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines.
- Shows a trend of diminished spontaneous lung metastasis dissemination in osteosarcoma models.
- Improves glucose tolerance during endotoxemia and in HFD-fed mice.
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 | 1 MG
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027), serving as an antibiotic for drug-resistant bacterial pathogens without detectable resistance. It functions by inhibiting cell wall synthesis, specifically targeting pyrophosphate of peptidoglycan precursors.
- Effective against drug-resistant bacterial pathogens.
- No detectable resistance observed.
- Inhibits cell wall synthesis through a specific mechanism targeting peptidoglycan precursors.
- Demonstrates inhibition of Staphylococcus strains with MICs ranging from 0.125-2 μg/mL in vitro.
- Exhibits a characterized pharmacokinetic profile in mice, including a Cmax of 219.3 μg/mL and a t1/2 of 2 hours following a 20 mg/kg intravenous single dose.