Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 3KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 3KG
Apexbio Technology LLC DTP3 TFA 1809784-29-9 (free-base) 25mg
DTP3 TFA is a small-molecule inhibitor targeting the GADD45 /MKK7 protein-protein interaction complex It is designed to disrupt this interaction thereby modulating downstream NF- B signaling involved in tumor cell survival DTP3 TFA exerts its biological activity primarily by binding directly to MKK7 (KD 64 81 nM) inducing conformational changes that dissociate GADD45 from MKK7 resulting in activation of JNK signaling In cell-based studies DTP3 TFA selectively inhibits proliferation of cancer cell lines with elevated GADD45 expression Based on these pharmacological properties DTP3 TFA holds research potential in the study and therapeutic intervention of cancers including multiple myeloma via disruption of GADD45 /MKK7 signaling
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 25KG
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 25KG
FUJIFILM BIOSCIENCES INC Trifluoroacetic Acid Solution (for Gradient Elution) | 76-05-1 | MFCD00004169 | 40mL
Trifluoroacetic Acid Solution (for Gradient Elution) | Putity: 25% | MW: 114.022 | 76-05-1 | MFCD00004169 | 40mL
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC Balixafortide TFA | 99.89% | 1978.16 | 50 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. It shows 1000-fold selectivity for CXCR4 compared to a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. It is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent and exhibits anti-cancer effects.
- Potent, selective, well-tolerated peptidic CXCR4 antagonist
- High selectivity for CXCR4 (1000-fold over CXCR7)
- Blocks β-arrestin recruitment and calcium flux
- Potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Anti-cancer effects
- Optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability
Medchemexpress LLC L-lysine, L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl- (TFA) | 99.45% | 748.91 | 25 MG
PHF6 TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation, mapped to the third microtubule-binding repeat region of the tau protein. Aggregated PHF6 TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells.
- Purity: 99.45%
- Molecular weight: 748.91 (free base)
- Chemical formula: C36H60N8O9.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Val-Gln-Ile-Val-Tyr-Lys
- Solubility in H2O: ≥ 50 mg/mL
- Store sealed and away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438128-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML
PSEM 89S TFA is a selective and brain-penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance (HC).
- Reversibly silenced transfected neurons by reducing cellular input resistance.
- Strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F-glycine receptor (GlyR).
- Shows good brain penetrance in mice after minimally invasive intraperitoneal administration.
- Almost completely suppressed fos in ChR2-expressing neurons in male Agrp-cre mice.
- Rises rapidly in serum and brain, and is mostly cleared from both compartments in 1 hour in C57BL/6 mice.
Medchemexpress LLC JBJ-09-063 TFA, 10mg | Molecular Weight- 670.67 | Formula- C33H30F4N4O5S
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. JBJ-09-063 TFA effectively reduces EGFR, Akt and ERK1/2 phosphorylation. JBJ-09-063 TFA is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer.
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
Medchemexpress LLC QTX125 trifluoroacetate | 2989537-78-0 | 99.9% | 100 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective histone deacetylase 6 (HDAC6) inhibitor with reported antitumor activity. Supplied as an off-white to gray solid for research use, it is available in multiple pack sizes and should be stored sealed and protected from moisture.
- Potent and selective HDAC6 inhibitor
- High reported purity and chemical stability
- Provided as a trifluoroacetate salt for improved handling
- Suitable for in vitro and preclinical research applications
- Store sealed, away from moisture; follow cold storage recommendations