Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Z-VRPR-FMK TFA (VRPR) | 95.0% | 790.81 | 200 UG
Z-VRPR-FMK TFA (VRPR) is a tetrapeptide and a selective, irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Apexbio Technology LLC FOXY-5-TFA-1MG
Foxy-5 TFA (CAS No 881188-51-8) is a synthetic peptide that plays a pivotal role in biomedical research particularly in cancer studies Originating from cancer research labs its mechanism of action involves mimicking the Wnt-5a protein which influences key signaling pathways such as the Wnt/ -catenin pathway This regulation is crucial in modulating cancer cell movement and metastasis Foxy-5 TFA demonstrates significant in vitro activity typically ranging from nanomolar to low micromolar concentrations It is commonly used in various cell models including breast and prostate cancer lines and has applications in animal studies for assessing metastasis inhibition Additionally it serves as an essential tool in drug screening to evaluate compounds targeting cancer metastasis pathways Experimental concentrations typically depend on the specific research design