Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Strem, An Ascensus Company CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Medchemexpress LLC xStAx-VHLL TFA | 100.0% | 3231.89 | 5 MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can also inhibit the proliferation of colon cancer cells and demonstrates anti-tumor activity.
- Induces β-catenin degradation in a dose-dependent manner in colorectal cancer cells in vitro
- Inhibits cell proliferation in vitro
- Inhibits Wnt/β-catenin signaling in HEK293T cells in vitro
- Shows antitumor activity in a mouse intestinal tumor model in vivo
- Reduces tumor number and active β-catenin protein levels in APC min/+ mice in vivo
Medchemexpress LLC WAAG-3R TFA | 99.8% | 1644.74 | 1 MG
WAAG-3R TFA is a biologically active peptide. Aggrecanases, which are part of the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases, cleave aggrecan, a main structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a significant aggrecanase in human osteoarthritic cartilage. This FRET peptide was utilized in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay with Ex/Em = 340/420 nm.
- Biologically active peptide.
- Utilized in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay.
- FRET peptide with Ex/Em = 340/420 nm.
Medchemexpress LLC JBJ-09-063 TFA | 99.6% | 670.67 | 5 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. It effectively reduces EGFR, Akt and ERK1/2 phosphorylation and is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer.
- Effectively inhibits cell growth and increases apoptosis, even in gefitinib-resistant H3255GR cells with an EGFR T790M mutation.
- Shows efficacy in H1975 cells expressing osimertinib-resistant mutations.
- Exhibits IC50s of 50 nM and 6 nM in Ba/F3 cell when used alone or in combination.
- Has favorable pharmacokinetic properties and good efficacy upon oral dosing.
Medchemexpress LLC Cn2 toxin TFA | 96.59% | 7588.60 | 5 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide identified as the main toxin found in scorpion venom. It specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Available in various quantities
- For research use only
Hampton Research 30% W/V POLYETHYLENE GL 200ML
HR2-609/30% w/v Polyethylene glycol 20,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC Gmprga Tfa | 98.1% | 587.69 | 1 MG
GMPRGA (TFA) is the trifluoroacetate salt form of GMPRGA, a compound that plays a role in bacterial processes. It is known for its ability to recognize spAimR within the bacterial cytosol, which subsequently induces lysogeny. This product is intended for research applications only and is not suitable for human use.
- Recognizes spAimR in the bacterial cytosol.
- Induces lysogeny in bacteria.
- For research purposes only.
Medchemexpress LLC Pemvidutide trifluoroacetate | 98.1% | 3873.35 | C182H275N39O54 | 5 MG
Pemvidutide TFA is a synthetic peptide acting as a dual agonist of the GLP-1 and glucagon receptors. Supplied for research use, it has been investigated for reductions in body weight, liver fat, and serum lipids, and is intended for preclinical and in-vitro studies only.
- Dual GLP-1 and glucagon receptor agonist activity.
- High purity (98.1%).
- Molecular weight 3873.35 Da.
- Provided as the trifluoroacetate salt for peptide stability.
- Available in small milligram sizes for research workflows.
- Store powder at -80°C (up to 2 years) or -20°C (up to 1 year).
Medchemexpress LLC Peptide R (TFA) | 98.3% | 900.08 (free base) | 1 MG
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It shows outstanding capacities to remodel the tumor stroma and can be used for solid tumor (glioblastoma, etc.) research.
- Synthetic and specific CXCR4 antagonist
- Remodels tumor stroma
- Used for solid tumor research (glioblastoma, etc.)
- Supports cancer immunotherapy
- Supports cancer metabolism and metastasis research
- Relevant to immunology and inflammation
- Relevant to GPCR/G protein studies
- Exhibits anti-cancer properties
- Modulates microglia reactivity
- Influences self-renewal mechanisms
- Supports angiogenesis research
- Acts as an inhibitor
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 25 MG
KQFK TFA is a peptide, the trifluoroacetate salt form of KQFK, and serves as an inactive control for KRFK, a peptide derived from TSP-1. This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C32H46F9N7O12
- Molecular weight: 891.73
- Purity (LCMS): 99.55%
- Appearance: White to off-white solid
- Storage: Powder at -80°C for 2 years or -20°C for 1 year; in solvent at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Medchemexpress LLC LL-37 amide TFA | 597562-32-8 | 99.3% | 4492.28 (free base) | 1 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1. It inhibits periodontal pathogens and exerts bactericidal effects by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It also regulates inflammatory responses by inhibiting factors like TNF-α and promotes angiogenesis. Amidation enhances its stability and reduces serum inhibition, making it useful in research for infection-related diseases, periodontal disease, deep tissue injuries, and wound healing.
- Improved stability and resistance to enzymatic degradation.
- Exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria.
- Accelerates wound healing and bacterial clearance in Staphylococcus aureus skin infection models.
- Safe concentration range for eukaryotic cells is 0.1-10 μM.