Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) | 96.6% | 7588.60 (free base) | 1 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide and the main toxin found in scorpion venom. This peptide specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6, making it a valuable tool for research in ion channel modulation and neurological diseases.
- Neurotoxic peptide
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Functions as an ion channel modulator
- Useful in neurological disease research
- Acts as an inhibitor
Medchemexpress LLC CL2A (TFA) | 2616704-22-2 | 99.5% | 1176.24 | C50H79N9O16 | 5 MG
CL2A (TFA) is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker for use in antibody-drug conjugate construction. The TFA salt form improves handling and stability and is designed to release payloads under acidic conditions to produce a bystander effect.
- Cleavable linker enabling payload release under acidic conditions.
- PEG8 spacer and triazole moiety for increased solubility and stability.
- Designed for conjugation to antibody cysteine residues via disulfide linkage.
- Available in small research-scale packages for use in ADC development.
- Stable as a powder when stored sealed at 4°C; shipped at room temperature.
Medchemexpress LLC TAM557 TFA | 98.5% | 1119.34 | 1 MG
TAM557 TFA is a cytotoxic tubulysin compound designed for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that incorporate a targeting principle. It is intended for research use only.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Appearance: solid, white to off-white
- Shipping at room temperature
- Store at -20°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC AT-1002 TFA | 835872-35-0 | 99.5% | 821.91 | 1 ML
AT-1002 TFA, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer. It belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier.
- Can undergo Cys-Cys dimerization.
- Treatment for up to 3 hours did not affect Caco-2 cell viability at any concentration.
- Reduced cell viability after 24 hours at concentrations of 2.5 mg/mL and higher.
- Cells remained viable after 24 hours if washed after 3 hours exposure, indicating it does not irreversibly damage cells.
Medchemexpress LLC Cl2e-SN38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 5 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) drug-linker consisting of an SN-38 payload attached via a CL2E linker in the trifluoroacetate (TFA) salt form. It is intended for preclinical research into ADCs, where SN-38 functions as a topoisomerase I inhibitor.
- Highly releasable and structurally stable antibody-SN-38 conjugate.
- Contains SN-38 payload, a topoisomerase I inhibitor.
- TFA salt form for improved solubility and handling.
- Available in small research quantities (5 MG).
- High purity suitable for preclinical ADC development.
Medchemexpress LLC Psalmotoxin 1 TFA | 880107-52-8 | 99.37% | 4689.39 | 500 UG
Psalmotoxin 1 is a protein toxin that binds at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It acts as a potent and selective ASIC1a inhibitor by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis and inhibit cell migration, proliferation, and invasion of cancer cells. It is utilized in research concerning cancers and neurological diseases.
- Potent and selective ASIC1a inhibitor with an IC50 of 0.9 nM
- Induces cell apoptosis
- Inhibits cell migration, proliferation, and invasion of cancer cells
- Used in research concerning cancers and neurological diseases
- Neuroprotective in a conscious model of stroke
- Inhibits tumor growth in breast cancer models
Medchemexpress LLC Nampt-IN-10 (TFA) | 2567724-20-1 | >98.6% | 701.59 | 25 MG
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. It shows cellular potency to A2780 and CORL23 cell lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs.
- Shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines.
- IC50 values are 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), and 1 nM (NCI-N87 with HER2 expressing).
- Can be used as a novel non-antimitotic payload for ADCs.
Medchemexpress LLC Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Mans peptide Tfa | 99.88% | 2498.83 | 5 MG
Medchemexpress LLC Cef20 TFA | 99.3% | 1057.19 | 5 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). It is for research use only.
- An HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503)
- For research use only