Acyl bromides
Apexbio Technology LLC Mepenzolate Bromide 76-90-4 1g
Mepenzolate bromide (CAS 76-90-4) is a synthetic quaternary ammonium compound that functions as a muscarinic acetylcholine receptor antagonist By inhibiting parasympathetic neural transmission it reduces gastric secretion and gastrointestinal motility Mepenzolate bromide is generally supplied as a white to light cream powder with high solubility in methanol limited solubility in water and chloroform and minimal solubility in ether This compound is widely employed in research investigating modulation of cholinergic signaling gastrointestinal physiology and autonomic pharmacology and serves as a tool compound for studying antimuscarinic mechanisms in vitro and in vivo
Medchemexpress LLC Tiotropium Bromide | 136310-93-5 | 99.9% | 472.42 | 5 MG
Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and the subsequent opening of the ligand-gated ion channel. This compound stops signaling between neurons, leading to muscle relaxation. It is also a long-acting, 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease and can improve symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
- mAChR antagonist
- Blocks binding of acetylcholine ligand
- Blocks subsequent opening of ligand-gated ion channel
- Long-acting, 24-hour anticholinergic bronchodilator
- Stops signaling between neurons
- Leads to muscle relaxation
- Used in the management of chronic obstructive pulmonary disease (COPD)
- Improves symptoms of COPD complicated by chronic heart failure
Medchemexpress LLC QX-314 (bromide) | 24003-58-5 | MFCD00083182 | 96.6% | 343.30 | C16H27BrN2O | 1 ML
QX-314 bromide is a membrane-impermeable, permanently charged sodium channel blocker provided as a ready-to-use 10 mM solution in DMSO or as a solid for reconstitution. It is commonly used in electrophysiology and neurophysiology experiments to selectively block intracellular voltage-gated sodium channels during recordings and manipulations.
- Membrane-impermeable quaternary lidocaine derivative.
- Available as 10 mM solution in DMSO or solid for reconstitution.
- Used to block intracellular voltage-gated sodium channels in electrophysiology.
- CAS number 24003-58-5 for unambiguous identification.
- Supplied with reported purity suitable for research applications.
Medchemexpress LLC 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-2'-methyluridine | 863329-65-1 | 99.4% | 468.43 | 100 MG
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-2'-methyluridine is a drug intermediate utilized in the synthesis of various active compounds.
- Used in the synthesis of various active compounds.
- Serves as a drug intermediate.
Apexbio Technology LLC Rocuronium Bromide 119302-91-9 100mg
Rocuronium Bromide (CAS 119302-91-9) is an aminosteroid compound that functions as a non-depolarizing neuromuscular blocking agent It acts by competitively antagonizing nicotinic acetylcholine receptors at the neuromuscular junction thereby inhibiting acetylcholine-induced depolarization and subsequent muscle contraction In research settings Rocuronium Bromide is utilized to investigate neuromuscular transmission and to model pharmacological blockade of skeletal muscle activity supporting studies in anesthesia muscle physiology and synaptic transmission mechanisms
Medchemexpress LLC (2e)-1-(3,4-dimethoxyphenyl)-5-fluoro-3-(4-fluorophenyl)-2-(2-fluorophenyl)pent-1-en-4-one bromide | 1390654-28-0 | >98.8% | 524.38 | 100 MG
KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hindering high-salt-induced NFAT5 and its target gene expressions. KRN2 also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site of Nfat5 exon 1.
- Effectively suppresses AIA in which innate immune cells play a predominant role.
- Effectively suppresses CIA as well as AIA in mice.
- Decreases the production of pro-inflammatory cytokines and autoantibodies.
- Reduces macrophage infiltration.
Selleck Chemical LLC Sepantronium Bromide (YM155) S1130-25mg
Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0 54 nM in HeLa-SURP-luc and CHO-SV40-luc cells does not significantly inhibit SV40 promoter activity but is observed to slightly inhibit the interaction of Survivin with XIAP YM155 down-regulates survivin and XIAP modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells Phase 2
AdipoGen Stain 7-I
Chemical. CAS 155862-95-6. Formula C27H22BrN3O6. MW 564.38. Synthetic. New class of highly photostable, water soluble fluorescent labels with large Stokes shift, high QY in aqueous media and pH tolerance.
Medchemexpress LLC Ipratropium bromide | 22254-24-6 | 1 ML
Ipratropium bromide is a muscarinic receptor antagonist, demonstrating IC50s of 2.9 nM for M1, 2 nM for M2, and 1.7 nM for M3 receptors. This compound effectively relaxes smooth muscle and is utilized in research focusing on conditions such as chronic obstructive pulmonary disease (COPD) and asthma.
- Targets mAChR
- Supports neurological disease and inflammation/immunology research
- Acts as a muscarinic receptor antagonist
- Exhibits IC50 values of 2.9 nM for M1, 2 nM for M2, and 1.7 nM for M3 receptors
- Relaxes smooth muscle
- Suitable for research on chronic obstructive pulmonary disease (COPD) and asthma
Medchemexpress LLC N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate | 79896-97-2 | C17H19N5O6 | 50 MG
N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate is the hydrate form of N6-Benzoyl-9-β-D-arabinofuranosyladenine, an adenosine analog. Adenosine analogs primarily function as smooth muscle vasodilators and have been shown to inhibit cancer progression. This product is intended for research use only.
- Hydrate form of N6-Benzoyl-9-β-D-arabinofuranosyladenine
- Adenosine analog
- Acts as a smooth muscle vasodilator
- Shown to inhibit cancer progression
- For research use only