Naphthalenes

Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 50 MG

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BI-0474 is a potent KRASG12C inhibitor that demonstrates an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows good anti-tumour activity in non-small cell lung cancer xenograft models. Designed by Boehringer Ingelheim, this compound is available for research use only.

• Potent KRASG12C inhibitor
• IC50 value of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
• Demonstrates anti-proliferative activity against NCI-H358 cells with G12C mutation
• Shows anti-tumour activity in non-small cell lung cancer xenograft models
• For research use only
• Purity of 99.83%
• Molecular weight of 587.74
• Chemical formula is C30H37N9O2S
• Appears as a white to off-white solid
• Target: KRAS-SOS1
• EC50 = 26 nM on NCI-H358 cells (G12C mutant)
• Soluble in DMSO at 100 mg/mL

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eMolecules​ (4-Cyano-3,5-difluorophenyl)zinc bromide, 0.5 M in THF | Synthonix |283.380 | C7H2BrF2NZn | 0.000 | [Br-].Fc1cc([Zn+])cc(F)c1C#N | 25ml | 812584956

(4-Cyano-3,5-difluorophenyl)zinc bromide, 0.5 M in THF | Synthonix |283.380 | C7H2BrF2NZn | 0.000 | [Br-].Fc1cc([Zn+])cc(F)c1C#N | 25ml | 812584956

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eMolecules​ Target Molecule Pemigatinib 25mg 574599730 T12401 1513857-77-6 [null] 487.508 C24H27F2N5O4

Target Molecule Pemigatinib 25mg 574599730 T12401 1513857-77-6 [null] 487.508 C24H27F2N5O4

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eMolecules​ 118486-95-6 | 5-Methyl-2-(tributylstannyl)furan | Synthonix - Stock | MFCD01319081 | 371.152 | C17H32OSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccc(C)o1 | 500mg | 525920516

5-Methyl-2-(tributylstannyl)furan | Synthonix - Stock | 118486-95-6 | MFCD01319081 | 371.152 | C17H32OSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1ccc(C)o1 | 500mg | 525920516

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eMolecules​ 134914-97-9 | 2-Methyl-4-(tributylstannyl)pyridine | Synthonix - Stock | MFCD16039584 | 382.179 | C18H33NSn | 98.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(C)c1 | 5g | 525921461

2-Methyl-4-(tributylstannyl)pyridine | Synthonix - Stock | 134914-97-9 | MFCD16039584 | 382.179 | C18H33NSn | 98.000 | CCCC[Sn](CCCC)(CCCC)c1ccnc(C)c1 | 5g | 525921461

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eMolecules​ 307496-33-9 | 2,6-Difluorobenzylzinc bromide, 0.50 M in THF | Synthonix272.400 | C7H5BrF2Zn | 0.000 | [Br-].Fc1cccc(F)c1C[Zn+] | 50ml | 532652762

2,6-Difluorobenzylzinc bromide, 0.50 M in THF | Synthonix | 307496-33-9272.400 | C7H5BrF2Zn | 0.000 | [Br-].Fc1cccc(F)c1C[Zn+] | 50ml | 532652762

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eMolecules​ 1395895-19-8 | 3-Fluoro-5-methoxyphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD11553258 | 229.331 | C7H6BrFMgO | 0.000 | [Br-].COc1cc(F)cc([Mg+])c1 | 50ml | 437237244

3-Fluoro-5-methoxyphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 1395895-19-8 | MFCD11553258 | 229.331 | C7H6BrFMgO | 0.000 | [Br-].COc1cc(F)cc([Mg+])c1 | 50ml | 437237244

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eMolecules​ 6627-22-1 | Methyl 6-chloropyrimidine-4-carboxylate | ChemScene | MFCD08689467 | 172.570 | C6H5ClN2O2 | 95.000 | COC(=O)c1cc(Cl)ncn1 | 1g | 536845092

Methyl 6-chloropyrimidine-4-carboxylate | ChemScene | 6627-22-1 | MFCD08689467 | 172.570 | C6H5ClN2O2 | 95.000 | COC(=O)c1cc(Cl)ncn1 | 1g | 536845092

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Medchemexpress LLC BI-2493 | 2937344-16-4 | C24H27N7OS | 25 MG

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BI-2493 is a structural analogue of BI-2865, acting as a highly selective and orally active pan-KRAS inhibitor. It can attenuate tumor growth and is suitable for cancer disease research.

• Highly selective pan-KRAS inhibitor
• Orally active
• Attenuates tumor growth
• Suitable for cancer disease research

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eMolecules​ (Tetrahydrofuran-3-ylmethyl)zinc bromide, 0.50 M in THF | Synthonix |230.410 | C5H9BrOZn | 0.000 | [Br-].[Zn+]CC1CCOC1 | 50ml | 794220303

(Tetrahydrofuran-3-ylmethyl)zinc bromide, 0.50 M in THF | Synthonix |230.410 | C5H9BrOZn | 0.000 | [Br-].[Zn+]CC1CCOC1 | 50ml | 794220303

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eMolecules​ 497923-83-8 | 2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 100ml | 532652663