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Filtered Search Results
eMolecules 250737-35-0 | (S)-2-tert-Butoxycarbonylamino-3-methoxy-3-oxopropylzinc iodide, 0.50 M in THF | Synthonix394.510 | C9H16INO4Zn | 0.000 | [I-].COC(=O)[C@@H](C[Zn+])NC(=O)OC(C)(C)C | 25ml | 703157755
(S)-2-tert-Butoxycarbonylamino-3-methoxy-3-oxopropylzinc iodide, 0.50 M in THF | Synthonix | 250737-35-0394.510 | C9H16INO4Zn | 0.000 | [I-].COC(=O)[C@@H](C[Zn+])NC(=O)OC(C)(C)C | 25ml | 703157755
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Medchemexpress LLC Trilaciclib hydrochloride | 1977495-97-8 | 99.7% | 519.47 g/mol | C24H32Cl2N8O | 1 MG
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Trilaciclib hydrochloride is the hydrochloride salt of trilaciclib, an orally active CDK4/6 inhibitor supplied as a research-grade analytical standard. It is provided as a light yellow to yellow solid for biochemical, cell-based, and preclinical studies, with documented activity against CDK4 and CDK6 and batch-specific characterization available.
- Orally active CDK4/6 inhibitor for cell-cycle arrest studies.
- High purity suitable for analytical and preclinical research.
- Documented potency: CDK4 IC50 ≈ 1 nM; CDK6 IC50 ≈ 4 nM.
- Solid formulation for ease of handling and storage.
- Batch-specific datasheet and COA available for quality verification.
- Intended for research use only; not for human or clinical use.
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Medchemexpress LLC BMS-214662 (hydrochloride) | 195981-08-9 | 98.5% | 526.1 | 25 MG
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BMS-214662 hydrochloride is a laboratory chemical that acts as an inhibitor. It is provided as a solid and is stable under recommended storage conditions, suitable for various research applications.
- Stable under recommended storage conditions
- Store at -20°C
- Protect from light
- Store under nitrogen
- Used for laboratory research
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Medchemexpress LLC BI-9787 is a zwitterionic inhibitor for ketohexokinase. | 3043939-18-7 | 99.5% | 489.58 | 5 MG
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BI-9787 is a zwitterionic inhibitor for ketohexokinase (KHK), with an IC50 of 12 nM for hKHK-A and 12.8 nM for hKHK-C. It demonstrates good metabolic stability in rat hepatocytes and favorable pharmacokinetic characteristics in rats.
- Exhibits good metabolic stability in rat hepatocyte.
- Demonstrates good pharmacokinetic characteristics in rats.
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Medchemexpress LLC Paroxetine hydrochloride hemihydrate | 110429-35-1 | >99.96% | 500 MG
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Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, widely used as an antidepressant. This compound also demonstrates GRK2 inhibitory capabilities with an IC50 of 14 μM. It plays a significant role in restraining T cell migration and inhibiting GRK2-induced ERK activation, which contributes to its anti-inflammatory effects by reducing pro-inflammatory cytokines like TNF-α and IL-1β in LPS-stimulated BV2 cells.
- Restrains T cell migration.
- Inhibits GRK2 induced ERK activation.
- Reduces pro-inflammatory cytokines (TNF-α and IL-1β).
- Relieves microglia-mediated neurotoxicity.
- Attenuates symptoms of CIA rats and decreases LV remodeling.
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Medchemexpress LLC Vardenafil (hydrochloride trihydrate) | 330808-88-3 | 99.7% | 25 MG
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Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. This compound can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- Selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- Inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- IC50s are >1000 nM for PDE3 and PDE4.
- Increases intracellular cGMP levels.
- Suitable for research of erectile dysfunction, hepatitis, and diabetes.
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Medchemexpress LLC Tamsulosin hydrochloride | 106463-17-6 | 99.8% | 100 MG
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It induces apoptosis and is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride also attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
- Orally active α1-adrenergic receptor antagonist
- Induces apoptosis
- Used for prostatic hyperplasia research
- Attenuates abdominal aortic aneurysm growth
- Inhibits inflammation in animal models
- Molecular weight: 444.97
- Chemical formula: C20H29ClN2O5S
- Appearance: Solid
- Color: White to off-white
- Recommended storage: 4°C, sealed, away from moisture and light
- Solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
- Solubility in DMSO: 50 mg/mL (112.37 mM)
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eMolecules 1621961-57-6 | (S)-5-OXOPIPERAZINE-2-CARBOXYLIC ACID HCL | AstaTech | MFCD28044202 | 180.590 | C5H9ClN2O3 | 97.000 | Cl.OC(=O)[C@@H]1CNC(=O)CN1 | 0.1g | 718056614
(S)-5-OXOPIPERAZINE-2-CARBOXYLIC ACID HCL | AstaTech | 1621961-57-6 | MFCD28044202 | 180.590 | C5H9ClN2O3 | 97.000 | Cl.OC(=O)[C@@H]1CNC(=O)CN1 | 0.1g | 718056614
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Medchemexpress LLC Ald-Ph-PEG6-acid | 2055013-55-1 | 95.3% | 50 MG
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Ald-Ph-PEG6-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a protein of interest. These molecules work by harnessing the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It appears as a colorless to light yellow viscous liquid.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Targets E3 ubiquitin ligase and a protein of interest
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Di-tert-butyl dicarbonate | 24424-99-5 | MFCD00008805 | 99.8% | 500g
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Di-tert-butyl dicarbonate is a general carboxylation reagent[1]
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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 10mg, CAS: 1869912-39-9.
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AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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Medchemexpress LLC 6-Methoxy-2-naphthoic acid | 2471-70-7 | 99.7% | 50 G
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6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone. It acts as an inhibitor of COX-1 and COX-2, playing a role in inflammation and pain-related research. It can also inhibit the synthesis of gastric mucosal prostaglandin E2. This compound is also known as a Naproxen impurity and is used in the synthesis of other active compounds.
- Active metabolite of Nabumetone
- Inhibitor of COX-1 and COX-2
- Inhibits synthesis of gastric mucosal prostaglandin E2
- Used in research for inflammation and pain-related diseases
- Impurity in Naproxen
- Used in the synthesis of other active compounds
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Cambridge Isotope Laboratories 1 2 3 4-TetraCN (PCN-27) (unlabeled) 100 ug/mL in nonane 1 mL
1 2 3 4-TetraCN (PCN-27) (unlabeled) 100 ug/mL in nonane 1 mL
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eMolecules 883-62-5 | 3-METHOXY-2-NAPHTHOIC ACID | AstaTech | MFCD00094168 | 202.209 | C12H10O3 | 95.000 | COc1cc2ccccc2cc1C(O)=O | 1g | 402180737
3-METHOXY-2-NAPHTHOIC ACID | AstaTech | 883-62-5 | MFCD00094168 | 202.209 | C12H10O3 | 95.000 | COc1cc2ccccc2cc1C(O)=O | 1g | 402180737
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eMolecules 5042-97-7 | Ambeed | 6-Chloro-2-naphthoic acid | 250mg | 525062203 | A150112 | MFCD11848443 | 206.63 | C11H7ClO2
Ambeed | 6-Chloro-2-naphthoic acid | 250mg | 525062203 | A150112 | 5042-97-7 | MFCD11848443 | 206.630 | C11H7ClO2
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