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Filtered Search Results
Medchemexpress LLC Fingolimod hydrochloride | 162359-56-0 | 99.9% | 343.93 | 1 G
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Fingolimod hydrochloride, also known as FTY720, is a potent sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. It acts as a pak1 activator and an immunosuppressant.
- Reverses the inhibitory effect of S1P on natural killer cell-mediated lysis of K562 tumor cells and dendritic cells.
- Enhances serum S1P levels by inhibiting S1P lyase activity.
- Attenuates microgliosis, modulating the microglia inflammatory phenotype.
- Possesses direct neuroprotective and anti-inflammatory properties.
- Can potentially switch microglia phenotype from detrimental to protective.
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Medchemexpress LLC Gsk-2256098 hydrochloride | 1416771-10-2 | 99.9% | 451.35 g/mol | C20H24Cl2N6O2 | 1 ML
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A selective focal adhesion kinase (FAK) inhibitor provided as a 10 mM stock solution in DMSO for in vitro research use. Supplied as a sealed 1 mL aliquot with high chemical purity and defined storage recommendations.
- High purity (99.9%).
- Ready-to-use 10 mM stock solution in DMSO.
- Small-volume 1 mL aliquot suitable for screening and assay development.
- Molecular weight 451.35 g/mol; molecular formula C20H24Cl2N6O2.
- Contains CAS 1416771-10-2 for unambiguous identification.
- Store at -80°C up to 6 months or -20°C up to 1 month (sealed, away from moisture).
- For research use only; not for clinical or human use.
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Medchemexpress LLC Gabapentin hydrochloride | 60142-95-2 | 98.0% | C9H18ClNO2 | 100 MG
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Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. It inhibits neuronal Ca2+ influx and reduces neurotransmitter release. This GABA analog can be used to relieve neuropathic pain.
- Potent, orally active P/Q type Ca2+ channel blocker
- Inhibits neuronal Ca2+ influx
- Reduces neurotransmitter release
- GABA analog for neuropathic pain relief
- Inhibits K+-induced Ca2+ increase in synaptosomes
- Decreases K+-evoked release of aspartate and glutamate
- Reduces K+-evoked noradrenaline release
- Improves cognitive performance in animal models
- Provides analgesic effects in animal models
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Medchemexpress LLC Gabapentin hydrochloride | 60142-95-2 | 98.0% | C9H18ClNO2 | 500 MG
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Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. It inhibits neuronal Ca2+ influx and reduces neurotransmitter release. It is also a GABA analog that can be used to relieve neuropathic pain.
- Potent and orally active P/Q type Ca2+ channel blocker
- Inhibits neuronal Ca2+ influx
- Reduces neurotransmitter release
- GABA analog for relieving neuropathic pain
- For research use only
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Ambeed AMBEED
5000869882 1-BROMO-2-NITRONAPHTHALENE 1GR
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000702369 A-NAPHTHOLBENZEIN 100MG
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Apexbio Technology LLC BI-D1870 501437-28-1 50mg
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BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research
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Apexbio Technology LLC BI-D1870 501437-28-1 10mM (in 1mL DMSO)
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BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research
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Selleck Chemical LLC 1-Hydroxy-2-naphthoic acid
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1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms
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Cayman Chemical MebhydrolIn1 5-naphthalen 25g
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A histamine H1 receptor antagonist (Ki = 7.6 nM); selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 180 nM); inhibits acid sphingomyelinase in H4 neuroglioma cells at 10 µM; binds to the FXR ligand-binding domain (Kd = 9.87 µM); inhibits GW 4064-induced transactivation of FXR in HEK293T cells expressing the human receptor; binds to Zika virus RdRp (Kd = 22.62 µM) and reduces viral replication in Zika-infected Vero cells (EC50 = 5.14 µM); decreases blood glucose and plasma HbA1c levels in db/db diabetic mice at 30 mg/kg
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![eMolecules 147700-62-7 | Ambeed | (3aR8aR)-22-Dimethyl-44688-pentaphenyltetrahydro-[13]dioxolo[45-e][132]dioxaphosphepine | 100mg | 632808995 | A1437931 | 572.641 | C37H33O4P](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502446076.PNG-250.jpg)
eMolecules 147700-62-7 | Ambeed | (3aR8aR)-22-Dimethyl-44688-pentaphenyltetrahydro-[13]dioxolo[45-e][132]dioxaphosphepine | 100mg | 632808995 | A1437931 | 572.641 | C37H33O4P
ChemScene | N-(2-Chloro-5-Nitrophenyl)Benzamide | 250mg | 632286272 | CS-0151386 | 205827-96-9 | MFCD01212006 | 276.680 | C13H9ClN2O3
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Aobchem AOBCHEM
5000865297 1-IODO-4-METHOXYNAPHTHALENE 1G
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Medchemexpress LLC Diphenidol hydrochloride | 3254-89-5 | 99.1% | C21H28ClNO | 1 ML
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Diphenidol hydrochloride is a non-selective antagonist of muscarinic M1-M4 receptors with anti-arrhythmic activity. It also acts as a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells, making it suitable for research in antivertigo and antinausea studies.
- Non-selective muscarinic M1-M4 receptor antagonist
- Potent non-specific blocker of voltage-gated Na+, K+, and Ca2+ channels
- Used in antivertigo and antinausea research
- High purity at 99.06%
- Solid, white to off-white appearance
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Ambeed AMBEED
5000867894 6-BROMO-2-CHLORO-18-NAPHTH 1GR
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Medchemexpress LLC Tolazoline hydrochloride | 59-97-2 | 99.9% | C10H13ClN2 | 1 ML
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Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. It inhibits Noradrenaline-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. It can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research.
- α-adrenergic receptor antagonist
- Inhibits Noradrenaline-induced cell contraction
- Modulates vascular resistance
- Increases arterial pressure
- Reverses bradycardia and tachypnea
- Used to study erectile dysfunction
- Used to study α2-adrenergic receptor agonist-related poisoning
- Used to study skin vascular disease research
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