Unsubstituted Phenols
Medchemexpress LLC Procyanidin B3 | 23567-23-9 | 1 MG
Procyanidin B3 is a natural product known for its antioxidant activity, oral bioavailability, and ability to penetrate the blood-brain barrier. It acts as a selective inhibitor of histone acetyltransferase (HAT), specifically by inhibiting p300 HAT-mediated acetylation of the androgen receptor. This product also helps alleviate intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex.
- Exhibits antioxidant activity
- Possesses oral bioavailability and blood-brain barrier penetration
- Functions as a selective histone acetyltransferase (HAT) inhibitor
- Specifically inhibits p300 HAT-mediated acetylation of the androgen receptor
- Alleviates intervertebral disc degeneration (IVDD) by inhibiting TLR4/MD-2 complex formation
- Applicable for research in prostate cancer and arthritis
- Does not affect HDAC or HMT (histone methyltransferase)
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.7% | 266.29 | 50 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR) with an IC50 of 0.8 μM. It inhibits the signaling of human PDGF α- and β-receptors, as well as the related stem cell factor receptor (c-Kit). This compound also acts as a potent inhibitor of FLT3.
- Potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR)
- Inhibits human PDGF α- and β-receptors
- Targets stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
Medchemexpress LLC Procyanidin A2 | 41743-41-3 | MFCD10566019 | 99.8% | 576.50 g/mol | C30H24O12 | 10 MG
Procyanidin A2 is a naturally occurring flavonoid dimer isolated from grapes and other plant sources, provided as a research-grade analytical reagent for laboratory and analytical applications. It is used as an analytical standard and in biochemical studies exploring antioxidant, antimicrobial, anti-inflammatory, and anti-cancer effects.
- High purity analytical standard suitable for research and analytical applications.
- Reported biological activities include antioxidant, antimicrobial, anti-inflammatory, and anti-cancer effects.
- Suitable for use in in vitro assays and analytical methods such as LC/MS.
- Well-characterized chemical identity: CAS 41743-41-3, formula C30H24O12, molecular weight 576.50 g/mol.
- Available in milligram-scale pack sizes for analytical workflows.
Medchemexpress LLC Syringaresinol diglucoside | 66791-77-3 | MFCD24369676 | 99.7% | 742.72 | C34H46O18 | 10 MG
Syringaresinol diglucoside is a natural lignan glycoside isolated from plant sources such as bamboo leaves. It is provided as a high-purity analytical standard for research use in biochemical, pharmacological, and analytical studies.
- Natural lignan glycoside isolated from plant sources.
- High purity (99.7%) suitable for analytical and in vitro studies.
- Molecular formula C34H46O18; molecular weight 742.72.
- CAS number 66791-77-3 for unambiguous identification.
- Supplied in milligram-scale quantities intended for research use.
Aobchem 2-Bromo-5-(tert-butyl)phenol | ≥95% | CAS 20942-68-1 | C10H13BrO | 1g
2-Bromo-5-(tert-butyl)phenol | ≥95% | CAS 20942-68-1 | C10H13BrO | 1g
Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | 5 MG
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from *Glycyrrhiza uralensis*. It functions as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound has shown the ability to consistently suppress eotaxin production and prevent the paradoxical adverse effects of dexamethasone on eotaxin production.
- Inhibits MUC5AC gene expression and mucus production and secretion.
- Regulates NF-κB, STAT6, and HDAC2.
- Decreases phorbol 12-myristate 13-acetate (PMA) stimulated MUC5AC gene expression.
- Reduces mucus production in NCI-H292 human airway epithelial cells with an IC50 value of 1.4 μM.
Medchemexpress LLC Eriodictyol-7-O-glucoside | 38965-51-4 | 5 MG
Eriodictyol-7-O-glucoside | 38965-51-4 | 5 MG
Medchemexpress LLC Branaplam hydrochloride | 1562338-39-9 | 99.4% | 429.94 | 100 MG
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective, and orally active survival motor neuron-2 (SMN2) splicing modulator. It has an EC50 of 20 nM for SMN and inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. This compound is capable of elevating full-length SMN protein and has been shown to extend survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective, and orally active
- SMN2 splicing modulator
- Elevates full-length SMN protein
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model
- Inhibits hERG with an IC50 of 6.3 μM
Aobchem 4-(Pyridin-2-yl)phenol | ≥95% | CAS 51035-40-6 | C11H9NO | 25g
4-(Pyridin-2-yl)phenol | ≥95% | CAS 51035-40-6 | C11H9NO | 25g
Medchemexpress LLC Isosilybin A | 142796-21-2 | MFCD32182560 | 5 MG
Isosilybin A, a flavonolignan isolated from *Silybum marianum*, acts as a PPARγ agonist. It activates apoptotic pathways by targeting the Akt-NF-kB-AR axis and alleviates inflammatory responses in rosacea models through inhibition of Erk and p38 signaling. This compound also demonstrates anti-prostate cancer activity and is utilized in treating cirrhosis and hepatitis.
- PPARγ agonist that activates apoptotic pathways
- Relieves inflammatory responses by inhibiting Erk and p38 signaling
- Exhibits anti-prostate cancer activity
- Used in the treatment of cirrhosis and hepatitis
- Helps prevent the liver from exposure to toxic substances
- Suitable for HPLC and GC analytical techniques
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | MFCD00270913 | 99.69% | 266.29 | 100 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), inhibiting signaling of human PDGF α- and β-receptors, and the stem cell factor receptor (c-Kit). It is also an inhibitor of FLT3. It has a purity of 99.69%.
- Potent and selective inhibitor of PDGFR
- Inhibits human PDGF α- and β-receptors
- Inhibits stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
- Suppresses viability of PLX4032-resistant melanoma cells
- Induces apoptosis of A375R cells
- Inhibits PDGFR phosphorylation
- Inhibits migration of A375R cells
- Suppresses A375R tumor growth in nud/nud mice
- Inhibits atherosclerotic plaque progression
Aobchem Phenol 4-methoxy- 1-methanesulfonate | ≥97% | CAS 19013-30-0 | C8H10O4S | 5g
Phenol 4-methoxy- 1-methanesulfonate | ≥97% | CAS 19013-30-0 | C8H10O4S | 5g
Medchemexpress LLC SN-011 | 2249435-90-1 | 99.9% | C25H19FN2O4S | 100 MG
SN-011 is a potent and selective mouse and human STING inhibitor with an IC50 of 76 nM for STING signaling. It competes with cyclic dinucleotide (CDN) for the STING dimer binding pocket, blocking CDN binding and activation. This product is used for research into STING-driven autoimmune and inflammatory diseases.
- Suppresses STING stimulator-induced expression of Ifnb, Cxcl10, and Il6 mRNA in mouse embryonic fibroblasts.
- Inhibits 2′3′-cGAMP-induced Ifnb expression and STING oligomerization/phosphorylation.
- Suppresses STING ER-to-Golgi translocation.
- Inhibits inflammation and autoimmunity in vivo.
- Protects Trex1-/- mice from death, improves survival, and reduces multiorgan inflammation.
Sigma Aldrich Fine Chemicals Biosciences Phenol solution BioReagent, Saturated with 0.1 M citrate buffer, pHÂ 4.3 +/- 0.2, for molecular biology | 108-95-2 | MFCD00002143 | 100ML
Phenol solution BioReagent, Saturated with 0.1 M citrate buffer, pHÂ 4.3 +/- 0.2, for molecular biology | Mol Wt: 94.11 | 108-95-2 | MFCD00002143 | 100ML
