Unsubstituted Phenols
Selleck Chemical LLC AG-490 S1143-50mg
AG-490 is an inhibitor of EGFR with IC50 of 0 1 M in cell-free assays 135-fold more selective for EGFR versus ErbB2 also inhibits JAK2 with no activity to Lck Lyn Btk Syk and Src
Selleck Chemical LLC Tyrphostin AG 879 S2816-5mg
Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 M 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR
Apexbio Technology LLC AG-14361 328543-09-5 5mg
AG-14361 (CAS 328543-09-5) is a highly selective inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki50 of less than 5 nM PARP-1 is integral to DNA repair and cell death pathways and is overexpressed in various tumor types AG-14361 has demonstrated the ability to sensitize homologous recombination (HR) and BRCA2-deficient cells to DNA-damaging agents at non-cytotoxic concentrations In human K562 cells AG-14361 enhances camptothecin-induced growth inhibition and cytotoxicity while increasing DNA single-strand breaks It also restores temozolomide sensitivity in mismatch repair-proficient cells Preclinical models indicate greater antitumor responses in BRCA2-deficient xenografts following AG-14361 administration supporting its use in DNA repair and cancer research
eMolecules Tyrphostin AG 879 | 148741-30-4 | MFCD00236450 | 100mg
Ambeed | Tyrphostin AG 879 | 100mg | 491168261 | A153685 | | 148741-30-4 | MFCD00236450 | 316.460 | C18H24N2OS
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Enzo Life Sciences Tyrphostin AG 1024 (5mg). CAS: 65678-07-1
Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression. Formula: C14H13BrN2O. MW: 305.2. Purity: ≥98% (HPLC (UV)). Solubility: Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin AG 1295 (5mg). CAS: 71897-07-9
PDGF inhibitor. Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor. Alternative name: 6,7-Dimethyl-2-phenylquinoxaline. Formula: C16H14N2. MW: 234.3. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C. Handling: Store tightly sealed in the dark. Protect from light.
Enzo Life Sciences Tyrphostin AG 527 (25mg). CAS: 133550-32-0
Alternative name: Tyrphostin B44, (-)-(R)-N-(alpha-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide. Formula: C18H16N2O3. MW: 308.3. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO or 100% ethanol. Long Term Storage: -20°C. Handling: Store tightly sealed in the dark. Protect from light.
Enzo Life Sciences Tyrphostin AG 1024 (1mg). CAS: 65678-07-1
Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression. Formula: C14H13BrN2O. MW: 305.2. Purity: ≥98% (HPLC (UV)). Solubility: Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol. Use/Stability: In a dissolved form it should be stable for at least 1 month. Long Term Storage: -20°C. Handling: Protect from light.
Sigma Aldrich Fine Chemicals Biosciences Tyrphostin AG 490 solid | 133550-30-8 | MFCD00236452 | 25MG
Tyrphostin AG 490 solid | Purity: >=98% (HPLC) | Mol Wt: 294.3 | 133550-30-8 | MFCD00236452 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Tyrphostin AG 825 >=92.5% | 149092-50-2 | MFCD01074971 | 2MG
Tyrphostin AG 825 >=92.5% | Purity: >=92.5% | Mol Wt: 397.47 | 149092-50-2 | MFCD01074971 | 2MG
Sigma Aldrich Fine Chemicals Biosciences Tyrphostin AG 490 solid | 133550-30-8 | MFCD00236452 | 5MG
Tyrphostin AG 490 solid | Purity: >=98% (HPLC) | Mol Wt: 294.3 | 133550-30-8 | MFCD00236452 | 5MG
Medchemexpress LLC Tyrphostin AG 879 | 148741-30-4 | 99.3% | 316.46 | 100 MG
This compound is a tyrosine kinase inhibitor that specifically acts on TrKA phosphorylation and also functions as a selective ErbB2 tyrosine kinase inhibitor. It demonstrates significantly higher selectivity for ErbB2 compared to EGFR. This agent exhibits anticancer properties by reducing cell proliferation and inducing apoptosis in various cell lines, and has shown to decrease tumor growth in animal models.
- Inhibits TrKA phosphorylation.
- Selective ErbB2 tyrosine kinase inhibitor.
- Exhibits at least 500-fold higher selectivity to ErbB2 than EGFR.
- Possesses anticancer activity.
- Decreases cell proliferation in various cell lines.
- Induces apoptosis in multiple cell lines.
- Reduces tumor growth in athymic, immunodepressed mice.