Azobenzenes
Medchemexpress LLC Licarin A | 51020-86-1 | MFCD20260801 | 5 MG
Licarin A is a neolignan found in various plants, known for its anti-allergic and anti-inflammatory effects. It reduces TNF-α and PGD2 production by inhibiting PKCα/βII and p38 MAPK pathways.
- Significantly reduces TNF-α production in DNP-HSA-stimulated RBL-2H3 cells
- Exhibits anti-allergic effects
- Reduces PGD2 production and COX-2 expression
- Demonstrates anti-inflammatory effects
- Inhibits PKCα/βII and p38 MAPK pathways
- Found in plants like Aristolochia taliscana, Machilus thunbergii, and Myristica fragrans
Medchemexpress LLC Pegaptanib sodium | 222716-86-1 | 90.51% | 50000 (Approximately) | 500 MG
Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, directed against vascular endothelial growth factor (VEGF)-165. It can be used for the study of neovascular age-related macular degeneration (AMD).
- Solid appearance.
- White to off-white color.
- Inhibits VEGF165-mediated phosphorylation of VEGFR2 and phospholipase Cγ.
- Inhibits VEGF165-induced calcium mobilization in human umbilical vein endothelial cells.
- Targets vascular endothelial growth factor-165.
- Suitable for the study of neovascular age-related macular degeneration.
Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 200 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. This compound demonstrates higher efficacy in specifically inhibiting cancer cells and shows low toxicity in normal cells.
- Potent PRMT5 inhibitor (IC50 = 7.5 μM)
- Exhibits anti-tumor activities
- Higher efficacy in inhibiting cancer cells with low toxicity in normal cells
- Inhibits colony-forming ability in PANC1 and HT29 cells
- Inhibits NF-κB activation and target gene expression in PDAC and CRC cells
- Decreases TNFα and IL8 expression in PDAC and CRC cells
- Displays significant anti-tumor effect in PANC1 and HT29 xenografted mice without visibly affecting body weight
Medchemexpress LLC Lys006 hydrochloride | 2619563-79-8 | 429.23 | 50 MG
LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 of 2 nM. It is extracted from patent WO2015092740A1, example 29, and is for research use only. It can be used for the research of inflammatory and autoimmune disorders.
- Potent inhibitor of LTA4H hydrolase
- IC50 of 2 nM
- Used for research on inflammatory and autoimmune disorders
- Currently in Phase 2 clinical trials for inflammatory acne, ulcerative colitis, hidradenitis suppurativa, and non-alcoholic fatty liver disease/nonalcoholic steatohepatitis
Medchemexpress LLC Nimbin | 5945-86-8 | 5 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties, showing promise for research into neurodegenerative diseases and viral infections.
- Orally active intermediate limonoid
- Prevents tau aggregation and increases cell viability
- Effective inhibitor of the dengue virus envelope protein
- Anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research of neurodegenerative diseases and viral infections
Medchemexpress LLC Ker047 (ALK2-IN-4) | 2248154-85-8 | 98.8% | 475.56 | 50 MG
KER047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. It can be used for research into metabolic diseases such as fibrodysplasia ossificans progressiva (FOP).
- Potent activin receptor-like kinase-2 (ALK2) inhibitor.
- Used for research of metabolic disease, specifically fibrodysplasia ossificans progressiva (FOP).
Medchemexpress LLC Manool | 596-85-0 | 290.48 | 100 MG
Manool is a diterpene derived from *Salvia officinalis*. It selectively induces cytotoxicity in cancer cells and arrests them at the G(2)/M phase of the cell cycle. For research use only.
- Diterpene from *Salvia officinalis*.
- Induces selective cytotoxicity in cancer cells.
- Arrests cancer cells at the G(2)/M phase of the cell cycle.
- Exhibits higher cytotoxic activity against HeLa (IC50=6.7 μg/mL) and U343 (IC50=6.7 μg/mL) cells.
- Shows a protective effect against chromosome damage induced by MMS in HepG2 cells.
Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.
- Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
- Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
- Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
- Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.
Medchemexpress LLC Nimbin | 5945-86-8 | 1 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It shows promise for research in neurodegenerative diseases and viral infections.
- Prevents tau aggregation
- Increases cell viability
- Effectively inhibits the envelope protein of the dengue virus
- Possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research in neurodegenerative diseases and viral infections
Medchemexpress LLC Catalposide | 6736-85-2 | 5 MG
Catalposide is an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). It inhibits the production of TNF-α, IL-1β, and IL-6, and also suppresses NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages. It is intended for research use only.
- Purity of 98.0%
- Inhibits TNF-α, IL-1β, and IL-6 production
- Suppresses NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages
- Displays IC50 > 10 μM against human A2780, A549, BGC-823, Bel-7402, and HT-29 cells
- Isolated from Catalpa ovata G. Don (Bignoniaceae)
Medchemexpress LLC Spdmv | 890409-85-5 | 96.4% | 354.44 g/mol | C15H18N2O4S2 | 100 MG
SPDMV is a glutathione-cleavable antibody-drug conjugate (ADC) linker supplied for research use. It is designed to connect antibodies to cytotoxic payloads and release the payload intracellularly via glutathione-mediated cleavage.
- Glutathione-cleavable disulfide linker.
- Intended for ADC synthesis and conjugation chemistry.
- Purity 96.37%.
- CAS number 890409-85-5.
- Molecular weight 354.44 g/mol.
- Chemical formula C15H18N2O4S2.
- Available in 100 MG vial.