Azobenzenes
Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 10 MG
GSK1702934A is a selective agonist for TRPC3, a transient receptor potential canonical channel. It plays a role in modulating cardiac contractility and arrhythmogenesis through the activation of TRPC3. In vitro studies have shown its ability to induce TRPC3/6-currents in HEK293 cells, with EC50 values of 0.08 mM for TRPC3 and 0.44 mM for TRPC6. It also induces transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes, and promotes NCX currents. In vivo, GSK1702934A has been observed to transiently increase blood pressure in conscious Sprague Dawley rats at doses ranging from 0.3-3 mg/kg.
- Acts as a selective agonist for TRPC3.
- Modulates cardiac contractility and arrhythmogenesis by activating TRPC3.
- Induces TRPC3/6-currents in HEK293 cells.
- Promotes NCX currents in TRPC3-overexpressing myocytes.
- Increases blood pressure in vivo in animal models.
Medchemexpress LLC MIND4-19 | 129544-85-0 | 99.9% | 373.47 | 5 MG
MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. This compound is intended for use in researching Huntington's disease.
- Solid, white to off-white appearance
- Soluble in DMSO for in vitro applications
- Can be dissolved using various co-solvents for in vivo protocols
- Targeted for SIRT2 inhibition
Medchemexpress LLC (R)-5,7-Dimethoxyflavanone | 1277188-85-8 | 5 MG
(R)-5,7-Dimethoxyflavanone exhibits potent antimutagenic activity against MeIQ mutagenesis in Ames test utilizing S. typhimurium TA100 and TA98 strains. Additionally, it significantly and dose-dependently inhibits inflammatory mediators.
- Potent antimutagenic activity
- Inhibits inflammatory mediators
- Molecular weight of 284.31
- Chemical formula C17H16O4
- Appears as a white to off-white solid
- Classified as a flavonoid and flavanone
- Initially sourced from plants
Medchemexpress LLC 2-(3-oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid | 1221962-86-2 | 98.3% | 25 MG
PS210 is a small-molecule activator of 3-phosphoinositide-dependent protein kinase-1 (PDK1) that engages the PIF-binding pocket and is used as a research reagent to study PDK1 signaling.
- Potent and selective PDK1 activator for research use.
- CAS number 1221962-86-2 for unambiguous identification.
- Molecular formula C19H15F3O5 and molecular weight 380.31 g·mol⁻¹.
- High purity (≈98%) suitable for biochemical assays.
- Supplied as a solid powder; recommended storage at -20°C for long-term stability.
- Available in small research pack sizes (25 mg) for laboratory studies.
eMolecules 1262771-85-6 | AstaTech | (4-ETHYLTHIAZOL-2-YL)METHANAMINE DIHYDROCHLORIDE | 1g | 718080323 | AT34437 | 95 | MFCD09864312 | 215.14 | C6H12Cl2N2S
Ambeed | 4-(Pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-34-dihydrobenzo[f][14]oxazepin-5(2H)-one hydrochloride | 1mg | 534568661 | A642597 | 1448754-43-5 | MFCD30377215 | 451.830 | C21H17ClF3N3O3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
![eMolecules 86047-86-1 | 1,4-DIAZASPIRO[5.5]UNDECAN-5-ONE | AstaTech | MFCD07373481 | 168.240 | C9H16N2O | 95.000 | O=C1NCCNC11CCCCC1 | 1g | 718056409](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465028.JPG-250.jpg)
eMolecules 86047-86-1 | 1,4-DIAZASPIRO[5.5]UNDECAN-5-ONE | AstaTech | MFCD07373481 | 168.240 | C9H16N2O | 95.000 | O=C1NCCNC11CCCCC1 | 1g | 718056409
1,4-DIAZASPIRO[5.5]UNDECAN-5-ONE | AstaTech | 86047-86-1 | MFCD07373481 | 168.240 | C9H16N2O | 95.000 | O=C1NCCNC11CCCCC1 | 1g | 718056409
Medchemexpress LLC Lupiwighteone | 104691-86-3 | 99.5% | 338.35 | C20H18O5 | 10 MG
Lupiwighteone is an isoflavone research compound used as a biochemical probe for studies of antioxidant, antimicrobial, and anticancer activity. It induces caspase-dependent and -independent apoptosis in cancer cells through inhibition of the PI3K/Akt/mTOR pathway. The material is supplied as a small solid suitable for preparation of DMSO stocks and in vivo formulation.
- Isoflavone small molecule for in vitro and in vivo research.
- Induces apoptosis via PI3K/Akt/mTOR pathway inhibition.
- Solubility: DMSO 100 mg/mL (in vitro); ≥2.5 mg/mL in 10% DMSO/90% corn oil (in vivo).
- Storage: store at 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month).
- Key identifiers: CAS 104691-86-3; formula C20H18O5; molecular weight 338.35.
eMolecules 1091-85-6 | Ambeed | 2-(5-(Dimethylamino)naphthalene-1-sulfonamido)acetic acid | 250mg | 586458002 | A836722 | MFCD00037734 | 308.35 | C14H16N2O4S
AstaTech | 5-BROMO-6-METHYL-1H-BENZIMIDAZOLE | 0.25g | 296384823 | W10484 | 95.000 | 116106-16-2 | MFCD11846340 | 211.062 | C8H7BrN2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
eMolecules 510772-86-8 | ChemScene | 26-Difluoroterephthalonitrile | 100mg | 599129682 | CS-0088971 | MFCD18806059 | 164.115 | C8H2F2N2
ChemScene | 26-Difluoroterephthalonitrile | 100mg | 599129682 | CS-0088971 | 510772-86-8 | MFCD18806059 | 164.115 | C8H2F2N2
eMolecules 215307-86-1 | Medchem Express | BMS 753 | 5mg | 572596439 | HY-107395 | MFCD18384955 | 351.402 | C21H21NO4
Ambeed | 23-Dihydro-14-benzodioxine-6-carboxylic acid | 5g | 552661122 | A227188 | 4442-54-0 | MFCD00463509 | 180.159 | C9H8O4
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
![Medchemexpress LLC 4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimidine-4,6-dicarboxamide | 544678-85-5 | MFCD09878513 | 99.2% | 410.42 g/mol | C22H20F2N4O2 | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238677.png-250.jpg)
Medchemexpress LLC 4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimidine-4,6-dicarboxamide | 544678-85-5 | MFCD09878513 | 99.2% | 410.42 g/mol | C22H20F2N4O2 | 5MG
DB04760 is a potent, highly selective, non-zinc-chelating inhibitor of matrix metalloproteinase-13 (MMP-13) with a reported IC50 of 8 nM. In preclinical studies it reduced paclitaxel-induced neurotoxicity and exhibited anticancer activity. The compound is supplied for research use in multiple solid and solution formats and is provided with high purity.
- Potent MMP-13 inhibitor (IC50 = 8 nM).
- Non-zinc-chelating mechanism reduces off-target zinc interaction risk.
- Shown to reduce paclitaxel-induced neurotoxicity in studies.
- Exhibits anticancer activity in reported preclinical work.
- High purity (≈99.2%) with molecular weight 410.42 and formula C22H20F2N4O2.
- Available in solid and DMSO solution formats for research applications.
Medchemexpress LLC HSP27 inhibitor J2 | 2133499-85-9 | 99.7% | 264.30 g/mol | C13H12O4S | 25MG
HSP27 inhibitor J2 is a small-molecule research reagent that inhibits heat shock protein 27 (HSP27) by inducing abnormal dimer formation and disrupting HSP27 polymer function. It is supplied as a purified solid for biochemical and cellular studies with documented solubility and storage recommendations.
- High purity (99.7%).
- Molecular weight 264.30 g/mol.
- Chemical formula C13H12O4S.
- Soluble in DMSO at 20 mg/mL (75.67 mM); hygroscopic DMSO may affect solubility.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 2 years) or -20°C (up to 1 year).
- Available in multiple pack sizes including 25 mg.
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.7% | 50 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor.
- Essential for the initiation of DNA replication in the cell cycle.
- For research use only.
Medchemexpress LLC DS-1971a | 1450595-86-4 | 99.3% | 50 MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 nM for hNaV1.7 and 59.4 nM for mNaV1.7. It exerts analgesic effects and addresses thermal hyperalgesia and mechanical hypersensitivity.
- Potent, selective, and orally active NaV1.7 inhibitor
- Inhibitory concentration (IC50) of 22.8 nM for hNaV1.7
- Exerts analgesic effects
- Soluble in DMSO at 100 mg/mL
- Powder stable for 3 years at -20°C and 2 years at 4°C
- Stable in solvent for 2 years at -80°C and 1 year at -20°C
- Targets sodium channel membrane transporter/ion channel
- Exhibits a favorable toxicological profile