Azobenzenes
Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.
- Potent PRMT5 inhibitor.
- Exhibits anti-tumor activities.
- Low toxicity in normal cells.
- Strongly inhibits colony forming ability in PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression.
- Decreases TNFα and IL8 expression.
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 50 MG
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. It is being investigated for its potential in treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid binds to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- Potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist.
- Potential for treating Chronic Obstructive Pulmonary Disease (COPD).
- Potential for treating asthma.
- Contains an l-phenylalanine-N-aroyl motif for binding to the metal ion in the MIDAS site.
Medchemexpress LLC Cadrofloxacin 25mg | 153808-85-6 | 25 MG
Cadrofloxacin is an orally active fluoroquinolone antibiotic supplied for research use only. It exhibits activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria and is provided as a solid powder for laboratory research and assay development.
- Orally active fluoroquinolone antibacterial agent.
- Active against aerobic and anaerobic Gram-positive and Gram-negative bacteria.
- Supplied as a solid powder suitable for research use.
- Molecular formula C19H20F3N3O4; molecular weight 411.38 g·mol⁻¹.
- Typical purity approximately 98.2% as reported by the manufacturer.
Medchemexpress LLC Valategrast | 220847-86-9 | MFCD18782681 | 98.6% | C30H32Cl3N3O4 | 10MG
Valategrast (R-411 free base) is a potent, orally active dual antagonist of integrins α4β1 (VLA-4) and α4β7 provided for research use in inflammation and respiratory disease studies. It is supplied as a solid, characterized material for preclinical and in vitro investigations; not for human therapeutic use.
- Potent orally active dual integrin antagonist useful for mechanistic studies.
- Applicable to COPD and asthma research models.
- High purity solid suitable for analytical and biological assays.
- Available in multiple small pack sizes for research flexibility.
- Characterized with molecular weight, formula, and purity data for reproducibility.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Catalposide | 6736-85-2 | MFCD28015867 | 1 MG
Catalposide is an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). It inhibits TNF-α, IL-1β, and IL-6 productions, and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages. This product is for research use only.
- Solid appearance
- White to yellow color
- Store at 4°C, protect from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protect from light
eMolecules 25109-86-8 | ChemScene | Methyl 2-(2-bromoethyl)benzoate | 250mg | 536865715 | CS-W022777 | MFCD21340317 | 243.1 | C10H11BrO2
Ambeed | 4-Nitrobenzo-15-crown-5 | 1g | 572962026 | A480372 | 60835-69-0 | MFCD00060713 | 313.306 | C14H19NO7
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Medchemexpress LLC Lupiwighteone | 104691-86-3 | 5 MG
Lupiwighteone is an isoflavone from wild-growing plants with antioxidant, antimicrobial, and anticancer properties. It induces apoptosis in human breast cancer cells by inhibiting the PI3K/Akt/mTOR pathway. For research use only.
- Antioxidant and antimicrobial effects.
- Anticancer properties: induces apoptosis in breast cancer cells by inhibiting PI3K/Akt/mTOR.
- Cytotoxicity against various cell lines (e.g., DU-145, SGC-7901).
- Induces cell cycle arrest and apoptosis in DU-145 cells.
- Dose-dependent reduction of cell cycle proteins (CDK1, 2, 4, 6, cyclinD1, B1) and increased ROS production.
- Activates mitochondria-based intrinsic apoptosis, up-regulating cytochrome c and caspase-3, and down-regulating p-Akt/Akt and VEGF.
![Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263530.png-250.jpg)
Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG
WWL113 is a selective, orally active small-molecule inhibitor of carboxylesterases Ces3 and Ces1f used in biochemical and in vivo research to probe lipid metabolism and metabolic syndrome. It has shown efficacy in mouse models, improving lipid and glucose parameters after oral dosing.
- Selective Ces3 and Ces1f inhibitor with potent activity.
- Demonstrated in vivo efficacy in metabolic disease models.
- High purity suitable for research applications.
- Soluble in DMSO and formulatable for in vivo dosing protocols.
- Applicable to biochemical, cell-based, and animal studies.
Medchemexpress LLC Methylglyoxal-bis(guanylhydrazone) | 459-86-9 | MFCD00067519 | ≥98.0% | 184.20 g·mol⁻¹ | C5H12N8 | 50 MG
Mitoguazone (methylglyoxal-bis(guanylhydrazone)) is a small-molecule research reagent that competitively inhibits S-adenosyl-methionine decarboxylase (SAMDC) and disrupts polyamine biosynthesis. It is used in biochemical and cellular studies to probe polyamine-dependent processes, mitochondrial effects, and apoptosis. Chemical identifiers include CAS 459-86-9, formula C5H12N8, and molecular weight 184.20 g·mol⁻¹.
- Competitive inhibitor of S-adenosyl-methionine decarboxylase (SAMDC).
- Disrupts polyamine biosynthesis for pathway and apoptosis research.
- Reported to be brain-penetrant and useful in cellular assays.
- Characterized chemical identifiers: CAS 459-86-9, formula C5H12N8, MW 184.20 g·mol⁻¹.
- Recommended storage sealed and away from moisture; in solvent: -80°C long-term, -20°C short-term.
- Reported supplier purity commonly ≥98% for research-grade material.
eMolecules 1918125-85-5 | Ambeed | (4S5S)-2-(2-(Diphenylphosphanyl)phenyl)-45-diphenyl-45-dihydrooxazole | 100mg | 633660447 | A1352088 | 483.551 | C33H26NOP
Ambeed | (S)-2-Methylpiperidine | 1g | 552802083 | A714691 | 3197-42-0 | MFCD01862169 | 99.177 | C6H13N
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Medchemexpress LLC Chromeceptin 10mg | 331859-86-0 | 10 MG
Chromeceptin is a small-molecule IGF signaling pathway inhibitor for research use that suppresses IGF2 expression and reduces phosphorylation of AKT and mTOR. Supplied as a high-purity solid suitable for biochemical and cell-based studies.
- High purity suitable for biochemical assays and cell-based studies.
- Inhibits IGF signaling and suppresses IGF2 expression.
- Reduces phosphorylation of AKT and mTOR in target cells.
- Available as a 10 mg powder with recommended low-temperature storage.
- Soluble in common organic solvents for assay preparation.
![eMolecules 52687-85-1 | Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502516461.JPG-250.jpg)
eMolecules 52687-85-1 | Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651
Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | 52687-85-1 | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651
eMolecules 136381-85-6 | Medchem Express | Lintitript | 5mg | 506403383 | HY-101764 | MFCD00868618 | 411.86 | C20H14ClN3O3S
Ambeed | 14-Dimethyl-1H-indole-3-carbaldehyde | 250mg | 525880699 | A438363 | 170489-16-4 | MFCD11505328 | 173.215 | C11H11NO
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Medchemexpress LLC Corypalmine | 27313-86-6 | 99.5% | 341.40 g/mol | C20H23NO4 | 10 MG
Corypalmine is a naturally occurring isoquinoline alkaloid isolated from Stephania cepharantha. It is reported to exhibit antifungal and antimicrobial activity and is supplied as a high-purity research chemical for biochemical and pharmacological studies.
- Isoquinoline alkaloid chemical class.
- Reported antifungal activity.
- Molecular formula C20H23NO4.
- Molecular weight 341.40 g/mol.
- High purity (99.48%).
- Supplied as a solid powder suitable for laboratory research.
- For research use only; not for human use.
Medchemexpress LLC Orismilast | 1353546-86-7 | 99.9% | 510.29 g/mol | C19H15Cl2F2NO7S | 100 MG
Orismilast (LEO-32731) is an orally active, selective phosphodiesterase 4 (PDE4) inhibitor used in research on inflammatory diseases. It exhibits potent inhibition of PDE4B and PDE4D splice variants and is supplied as a high-purity research compound for in vitro and preclinical studies.
- Selective PDE4 inhibitor with activity against PDE4B and PDE4D.
- Purity 99.9%.
- Molecular weight 510.29 g/mol; formula C19H15Cl2F2NO7S.
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Powder storage: -20°C for long-term stability; aliquot to avoid freeze-thaw.
- Intended for in vitro and preclinical research use only.