Azobenzenes
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.7% | 50 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor.
- Essential for the initiation of DNA replication in the cell cycle.
- For research use only.
Medchemexpress LLC DS-1971a | 1450595-86-4 | 99.3% | 50 MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 nM for hNaV1.7 and 59.4 nM for mNaV1.7. It exerts analgesic effects and addresses thermal hyperalgesia and mechanical hypersensitivity.
- Potent, selective, and orally active NaV1.7 inhibitor
- Inhibitory concentration (IC50) of 22.8 nM for hNaV1.7
- Exerts analgesic effects
- Soluble in DMSO at 100 mg/mL
- Powder stable for 3 years at -20°C and 2 years at 4°C
- Stable in solvent for 2 years at -80°C and 1 year at -20°C
- Targets sodium channel membrane transporter/ion channel
- Exhibits a favorable toxicological profile
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.0% | 100 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor. This compound is extracted from patent WO2019165473A1 and targets Cdc7, a serine-threonine protein kinase enzyme essential for initiating DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor
- Extracted from patent WO2019165473A1
- Targets serine-threonine protein kinase enzyme Cdc7
- Essential for DNA replication initiation
- Appearance: solid, white to light yellow
- Molecular weight: 445.47
- Molecular formula: C25H23N3O5
amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259801.png-250.jpg)
Medchemexpress LLC 2-pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG
BPK-25 is an acrylamide-containing small-molecule research reagent that promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins and inhibits TMEM173 (STING) activation, resulting in modulation of NF-κB signaling. Supplied as a high-purity solid for in vitro and biochemical research; not intended for human use.
- Promotes NuRD complex protein degradation by covalent protein engagement.
- Inhibits STING (TMEM173) activation by the cyclic dinucleotide cGAMP.
- High purity suitable for biochemical assays and in vitro studies.
- Supplied as an off-white to light yellow solid for convenient handling.
- Recommended storage: 4°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for clinical or human use.
Medchemexpress LLC Firibastat (QGC001) | 648927-86-0 | 98.0% | 368.51 | 1 MG
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. It selectively and specifically inhibits the conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.
- Orally active and brain penetrating.
- Functions as a proagent.
- First-in-class brain aminopeptidase A (APA) inhibitor.
- Selectively inhibits conversion of brain angiotensin-II into angiotensin-III.
- Decreases blood pressure in hypertensive rats.
- Crosses gastrointestinal and blood-brain barriers.
- Generates two active molecules that inhibit brain APA activity.
- Blocks brain angiotensin III formation.
Medchemexpress LLC Sudoxicam 50mg | 34042-85-8 | 50MG
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class Sudoxicam has potent anti-inflammatory anti-edema and antipyretic activity[1 [2 [3
eMolecules 2643-85-8 | Medchem Express | Oxypeucedanin hydrate | 5mg | 510478334 | HY-N2622 | MFCD01725702 | 304.298 | C16H16O6
Ambeed | 1-(4-Chlorophenyl)-1H-pyrazole-4-carbaldehyde | 250mg | 600841992 | A507606 | 63874-99-7 | MFCD07643175 | 206.630 | C10H7ClN2O
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Medchemexpress LLC WWL113 | 947669-86-5 | 99.7% | 466.53 | 1 ML
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. It appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases).
- Inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
- Significantly increases UCP1 protein expression in brown adipocytes at 1 μM.
- Has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
- Results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance (30 mg/kg, orally once a day).
- Ameliorates obesity-diabetes in mice.
Sigma Aldrich Fine Chemicals Biosciences 4-(Phenylazo)diphenylamine 97% | 101-75-7 | MFCD00003023 | 5G
4-(Phenylazo)diphenylamine 97% | Purity: 97% | Mol Wt: 273.33 | 101-75-7 | MFCD00003023 | 5G
Medchemexpress LLC EPQpYEEIPIYL | 147612-86-0 | 99.5% | 1473.52 | 10 MG
EPQpYEEIPIYL is a phosphopeptide that functions as a Src homology 2 (SH2) domain ligand. It activates Src family members such as Lck, Hck, and Fyn by binding to their SH2 domains.
- Functions as a phosphopeptide and a Src homology 2 (SH2) domain ligand.
- Activates Src family members such as Lck, Hck, and Fyn.
- Exhibits high-affinity binding to GST fusion proteins of the Lck SH2 domain and the Src SH2 domain.
- For research use only.
eMolecules 129544-85-0 | Medchem Express | MIND4-19 | 5mg | 721434759 | HY-147233 | MFCD01614372 | 373.47 | C22H19N3OS
ChemScene | 222-Trifluoro-1-(4-(trifluoromethyl)phenyl)ethanol | 100mg | 712788673 | CS-0436388 | 150698-81-0 | MFCD16067901 | 244.136 | C9H6F6O
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Medchemexpress LLC Orismilast (LEO-32731) | 1353546-86-7 | 99.9% | 510.29 | C19H15Cl2F2NO7S | 50 MG
Orismilast is an orally active, selective phosphodiesterase 4 (PDE4) inhibitor provided as a solid research reagent for in vitro and in vivo studies of inflammatory and dermatological disease pathways. It is supplied with high purity and characterized physical data for laboratory use only.
- Selective PDE4 inhibitor for inflammatory research.
- High purity (99.88%) solid suitable for analytical and biological assays.
- Molecular weight 510.29 and formula C19H15Cl2F2NO7S for precise dosing and calculations.
- Available in small-scale packages including 50 mg for preclinical studies.
- Stable when stored frozen; follow manufacturer storage recommendations.
Medchemexpress LLC DB04760 | 544678-85-5 | 99.2% | 410.42 g·mol⁻¹ | C22H20F2N4O2 | 50MG
DB04760 is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor (IC50 = 8 nM) used as a research reagent in preclinical studies. It has been reported to reduce paclitaxel-induced neurotoxicity and to exhibit anticancer activity. The compound has formula C22H20F2N4O2, molecular weight 410.42 g·mol⁻¹, and is supplied in solid and solution forms with high purity suitable for biological assays.
- Potent MMP-13 inhibition with IC50 = 8 nM.
- Non-zinc-chelating mechanism for selective target studies.
- Shown to reduce paclitaxel-induced neurotoxicity in models.
- Reported anticancer activity in preclinical research.
- Available as solid and as 10 mM solution in DMSO for assay flexibility.
- High purity (~99%) appropriate for biological testing.
Medchemexpress LLC Atuliflapon (AZD5718) | 2041075-86-7 | 99.0% | 5 MG
Atuliflapon (AZD5718) is a potent, orally active small-molecule inhibitor of FLAP (5-lipoxygenase activating protein) supplied as a solid research compound. It is reported to have an IC50 of 2 nM and is provided with high purity and defined storage conditions for preclinical and in vitro studies.
- Potent FLAP inhibitor (IC50 ~2 nM)
- White to off-white solid powder form
- Molecular formula C24H26N6O3, molecular weight 446.50 g/mol
- Reported purity 98.97%
- Storage: powder -20°C (long term) or 4°C (short term)
- Intended for research use only