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Filtered Search Results
Medchemexpress LLC 2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 100 MG
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C-021 is a small-molecule CCR4 antagonist developed for research applications in immunology and receptor pharmacology. It is provided as a solid powder with high purity and is used in biochemical assays and functional chemotaxis studies.
- Potent CCR4 antagonist with nanomolar activity.
- High purity suitable for biochemical and cellular assays.
- Supplied as a solid powder for flexible formulation.
- Stable when stored under recommended conditions.
- Appropriate for in vitro and in vivo pharmacology studies.
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Medchemexpress LLC 4-hydroxy-2-methyl-1,1-dioxo-N-(1,3-thiazol-2-yl)-1λ6,2-benzothiazine-3-carboxamide | 34042-85-8 | MFCD00866053 | 100.0% | 337.37 g/mol | C13H11N3O4S2 | 25 MG
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Sudoxicam is a reversible, orally active cyclooxygenase (COX) antagonist and a non-steroidal anti-inflammatory compound of the enol-carboxamide class supplied for research and analytical use only. It demonstrates anti-inflammatory, anti-edema, and antipyretic activity and is provided as a solid and in DMSO solution formulations for laboratory studies.
- Reversible, orally active COX antagonist.
- High reported purity suitable for analytical work.
- Chemical formula C13H11N3O4S2 and molecular weight 337.37 g/mol.
- Soluble in DMSO; ultrasonic warming may improve solubility.
- Stable as powder at -20°C for long-term storage; in solvent storage guidelines provided.
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Medchemexpress LLC 5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one | 2133499-85-9 | MFCD32201069 | 99.7% | 264.30 | C13H12O4S | 5MG
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HSP27 inhibitor J2 (J2) is a small-molecule inhibitor of heat shock protein 27 (HSP27) that induces abnormal HSP27 dimer formation and inhibits formation of HSP27 giant polymers, disrupting HSP27 chaperone function and reducing cellular protection. In cellular studies J2 enhances the antiproliferative activity of 17-AAG and sensitizes cells to cisplatin, supporting its use in mechanistic and combination oncology research.
- Inhibits HSP27 chaperone activity by promoting abnormal dimer formation.
- Enhances antiproliferative effects of HSP90 inhibition in cell assays.
- Sensitizes cells to platinum-based chemotherapy in vitro.
- High purity (99.7%) suitable for biochemical and cell-based studies.
- Supplied as milligram-scale solid packs with good DMSO solubility for assay preparation.
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eMolecules 627034-85-9 | Medchem Express | NF449 (octasodium) | 1mg | 559839452 | HY-112461A | MFCD03791135 | 1505.05 | C41H24N6Na8O29S8
Medchem Express | NF449 (octasodium) | 1mg | 559839452 | HY-112461A | 627034-85-9 | MFCD03791135 | 1505.050 | C41H24N6Na8O29S8
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eMolecules 82782-85-2 | Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate | Ambeed | MFCD06797484 | 181.210 | C8H7NO2S | 98.000 | COC(=O)c1cc2sccc2[nH]1 | 100mg | 490503631
Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate | Ambeed | 82782-85-2 | MFCD06797484 | 181.210 | C8H7NO2S | 98.000 | COC(=O)c1cc2sccc2[nH]1 | 100mg | 490503631
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Medchemexpress LLC Atuliflapon (AZD5718) | 2041075-86-7 | 99.0% | 100 MG
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Atuliflapon (AZD5718) is a small-molecule, orally active inhibitor of 5-lipoxygenase activating protein (FLAP) investigated as a research compound for cardiovascular indications such as coronary artery disease. It potently suppresses leukotriene production and has documented preclinical and clinical pharmacology data.
- Oral FLAP inhibitor with potent activity (reported FLAP IC50 ≈ 2 nM).
- Reduces leukotriene production in human whole blood.
- Reported molecular weight 446.50 g·mol⁻¹ and formula C24H26N6O3.
- High purity (about 99.0%), white to off-white solid.
- Soluble in DMSO (≈125 mg/mL); sonication may be required for full dissolution.
- Powder storage: -20°C for long-term stability; in solvent, store at -80°C when possible.
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Medchemexpress LLC DB04760 (compound 4) | 544678-85-5 | MFCD09878513 | 99.2% | 410.42 g/mol | C22H20F2N4O2 | 10MG
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DB04760 is a small-molecule MMP-13 inhibitor (compound 4) reported as a potent, highly selective, non-zinc-chelating inhibitor with an IC50 of 8 nM. It has been used in studies showing reduction of paclitaxel-induced neurotoxicity and anticancer activity, and is supplied for research use with defined purity and solubility characteristics.
- Potent MMP-13 inhibitor with IC50 = 8 nM.
- Highly selective non-zinc-chelating mechanism.
- Molecular formula C22H20F2N4O2, molecular weight 410.42 g/mol.
- CAS number 544678-85-5.
- Purity 99.2%.
- Soluble in DMSO at ≥100 mg/mL; in vivo formulation: 10% DMSO then 90% corn oil.
- Reported to reduce paclitaxel neurotoxicity and exhibit anticancer activity.
- Available in multiple small-scale pack sizes for research use.
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eMolecules 2170033-85-7 | Ambeed | (S)-2-(Benzo[b]thiophen-2-yl)-4-benzyl-45-dihydrooxazole | 50mg | 665578597 | A1493991 | 293.38 | C18H15NOS
Ambeed | Methyl 4-amino-3-(trifluoromethoxy)benzoate | 1g | 525118326 | A202043 | 457097-93-7 | MFCD15527567 | 235.162 | C9H8F3NO3
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Medchemexpress LLC Gpx4-in-3 | 2761004-85-5 | 99.8% | C29H24ClN3O3S | 50 MG
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Gpx4-in-3 | 2761004-85-5 | 99.8% | C29H24ClN3O3S | 50 MG
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Medchemexpress LLC Atuliflapon (AZD5718) | 2041075-86-7 | 99.0% | 25 MG
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Atuliflapon (AZD5718) is a small-molecule, orally active inhibitor of 5-lipoxygenase activating protein (FLAP) used in preclinical and clinical research to modulate leukotriene biosynthesis and investigate cardiovascular inflammation.
- Inhibits FLAP with low-nanomolar potency in clinical studies.
- Demonstrates target engagement via reduced LTB4 and LTE4 biomarkers.
- Suitable for in vitro human and translational studies; species-dependent activity limits some animal models.
- Provided as a solid powder with high purity for research use.
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eMolecules 544678-85-5 | Medchem Express | DB04760 | 1mg | 536984011 | HY-125166 | MFCD09878513 | 410.425 | C22H20F2N4O2
Medchem Express | DB04760 | 1mg | 536984011 | HY-125166 | 544678-85-5 | MFCD09878513 | 410.425 | C22H20F2N4O2
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Chemscene ChemScene | 2-Amino-3-hydroxynitrobenzene | 500G | CS-W008642 | 0.98 | 603-85-0| MFCD00010875 | 154.13
ChemScene | 2-Amino-3-hydroxynitrobenzene | 500G | CS-W008642 | 0.98 | 603-85-0| MFCD00010875 | 154.13
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Medchemexpress LLC 4-hydroxy-2-methyl-1,1-dioxo-N-(1,3-thiazol-2-yl)-1λ6,2-benzothiazine-3-carboxamide | 34042-85-8 | MFCD00866053 | 100.0% | 337.37 g·mol⁻1 | C13H11N3O4S2 | 10 MG
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Sudoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the enol-carboxamide class that acts as a reversible, orally active cyclooxygenase (COX) antagonist. Provided as a research-grade chemical for in vitro and analytical use.
- Reversible COX antagonist for inflammation research.
- Analytical-grade solid with molecular formula C13H11N3O4S2 and molecular weight 337.37 g·mol⁻¹.
- High purity (99.96%), suitable for research and analytical applications.
- Available in small package sizes (1 mg, 5 mg, 10 mg) for assay and method development.
- Storage: powder - -20°C (3 years), 4°C (2 years); in solvent - -80°C (6 months), -20°C (1 month).
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Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG
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PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. It may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects, and for targeted bone regeneration.
- Potent and selective PYK2 inhibitor with an IC50 of 637 nM.
- Promotes osteogenesis of hMSC cultures, increasing alkaline phosphatase (ALP) activity and mineralization.
- Enhances osteoblast proliferation.
- Enhances calcium deposition.
- Increases cell proliferation activity in murine bone marrow-derived mesenchymal stem cells (BMSC).
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Medchemexpress LLC Voacamine | 3371-85-5 | 10 MG
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Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. It inhibits nuclear translocation and enhances the effect of Doxorubicin by interfering with P-glycoprotein (P-gp) function. It promotes apoptosis-independent autophagic cell death in human osteosarcoma cells, activates the mitochondrial-associated apoptosis signaling pathway, and inhibits the PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine also inhibits EGFR to exert oncogenic activity against colorectal cancer.
- High purity of 99.64%
- Inhibits nuclear translocation
- Enhances Doxorubicin efficacy by interfering with P-gp function
- Promotes apoptosis-independent autophagic cell death
- Suppresses breast cancer progression via PI3K/Akt/mTOR pathway inhibition
- Exerts oncogenic activity against colorectal cancer by inhibiting EGFR
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