Azobenzenes
Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.
- Potent PRMT5 inhibitor.
- Exhibits anti-tumor activities.
- Low toxicity in normal cells.
- Strongly inhibits colony forming ability in PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression.
- Decreases TNFα and IL8 expression.
Medchemexpress LLC DS-1971a | 1450595-86-4 | 99.3% | 50 MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 nM for hNaV1.7 and 59.4 nM for mNaV1.7. It exerts analgesic effects and addresses thermal hyperalgesia and mechanical hypersensitivity.
- Potent, selective, and orally active NaV1.7 inhibitor
- Inhibitory concentration (IC50) of 22.8 nM for hNaV1.7
- Exerts analgesic effects
- Soluble in DMSO at 100 mg/mL
- Powder stable for 3 years at -20°C and 2 years at 4°C
- Stable in solvent for 2 years at -80°C and 1 year at -20°C
- Targets sodium channel membrane transporter/ion channel
- Exhibits a favorable toxicological profile
Medchemexpress LLC Lupiwighteone | 104691-86-3 | 99.5% | 338.35 | C20H18O5 | 10 MG
Lupiwighteone is an isoflavone research compound used as a biochemical probe for studies of antioxidant, antimicrobial, and anticancer activity. It induces caspase-dependent and -independent apoptosis in cancer cells through inhibition of the PI3K/Akt/mTOR pathway. The material is supplied as a small solid suitable for preparation of DMSO stocks and in vivo formulation.
- Isoflavone small molecule for in vitro and in vivo research.
- Induces apoptosis via PI3K/Akt/mTOR pathway inhibition.
- Solubility: DMSO 100 mg/mL (in vitro); ≥2.5 mg/mL in 10% DMSO/90% corn oil (in vivo).
- Storage: store at 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month).
- Key identifiers: CAS 104691-86-3; formula C20H18O5; molecular weight 338.35.
![Medchemexpress LLC 3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one | 924377-85-5 | MFCD08868156 | 99.1% | 395.52 g/mol | C22H25N3O2S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264561.png-250.jpg)
Medchemexpress LLC 3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one | 924377-85-5 | MFCD08868156 | 99.1% | 395.52 g/mol | C22H25N3O2S | 5 MG
GSK1702934A is a small-molecule activator selective for TRPC3 and TRPC6 channels used as a research tool to probe TRPC-mediated calcium signaling. It induces TRPC3/6-dependent currents and has been applied to studies of cardiac contractility and arrhythmogenesis in cellular and tissue models. The compound is offered in solid form and as DMSO solution for experimental convenience.
- Selective TRPC3/6 activation for targeted functional studies.
- High purity suitable for biochemical and electrophysiology assays.
- Available as small solid quantities and as DMSO solution for convenience.
- Supports studies of cardiac contractility and arrhythmogenesis.
- Compatible with cellular assays and patch-clamp electrophysiology.
![eMolecules AstaTech / IMIDAZO[12-A]PYRAZIN-8-OL / 0.25g / 268500354 / 72211 / 95.000 / 434936-85-3 / MFCD11846490 / 135.126 / C6H5N3O](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502455661.PNG-250.jpg)
eMolecules AstaTech / IMIDAZO[12-A]PYRAZIN-8-OL / 0.25g / 268500354 / 72211 / 95.000 / 434936-85-3 / MFCD11846490 / 135.126 / C6H5N3O
AstaTech / IMIDAZO[12-A]PYRAZIN-8-OL / 0.25g / 268500354 / 72211 / 95.000 / 434936-85-3 / MFCD11846490 / 135.126 / C6H5N3O
eMolecules AstaTech / 3-(AMINOMETHYL)BENZAMIDE / 0.25g / 416218579 / Y10174 / 96.000 / 102562-86-7 / MFCD07186292 / 150.181 / C8H10N2O
AstaTech / 3-(AMINOMETHYL)BENZAMIDE / 0.25g / 416218579 / Y10174 / 96.000 / 102562-86-7 / MFCD07186292 / 150.181 / C8H10N2O
eMolecules 20197-86-8 | ChemScene | 2-Chloro-67-dimethoxyquinazolin-4(3H)-one | 100mg | 718356728 | CS-0226197 | MFCD08458256 | 240.64 | C10H9ClN2O3
Ambeed | 5-Amino-1-(tert-butyl)-1H-pyrazol-3-ol | 250mg | 491641310 | A210752 | 359867-35-9 | MFCD14607822 | 155.201 | C7H13N3O
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Medchemexpress LLC HSDVHK-NH2 | 848644-86-0 | 99.5% | 720.78 | 10 MG
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction. It has an IC50 of 1.74 μg/mL (2.414 pM) and shows strong antagonism against αvβ3-GRGDSP interaction. This compound inhibits HUVEC proliferation by inducing cell death through caspases activations, which is linked to increased p53 expression.
- Antagonist of integrin αvβ3-vitronectin interaction
- Inhibits bFGF-induced cell migration
- Shows strong antagonism against αvβ3-GRGDSP interaction
- Inhibits HUVEC proliferation
- Induces HUVEC cell death via caspases activations
- Mechanism related to increased p53 expression
eMolecules ChemScene / (5-Methyl-6-morpholinopyridin-3-yl)boronic acid / 100mg / 712787972 / CS-0338831 / 0.000 / 1191062-85-7 / MFCD10566507 / 222.050 / C10H15BN2O3
ChemScene / (5-Methyl-6-morpholinopyridin-3-yl)boronic acid / 100mg / 712787972 / CS-0338831 / 0.000 / 1191062-85-7 / MFCD10566507 / 222.050 / C10H15BN2O3
Medchemexpress LLC Orismilast (LEO-32731) | 1353546-86-7 | 99.9% | 510.29 | C19H15Cl2F2NO7S | 50 MG
Orismilast is an orally active, selective phosphodiesterase 4 (PDE4) inhibitor provided as a solid research reagent for in vitro and in vivo studies of inflammatory and dermatological disease pathways. It is supplied with high purity and characterized physical data for laboratory use only.
- Selective PDE4 inhibitor for inflammatory research.
- High purity (99.88%) solid suitable for analytical and biological assays.
- Molecular weight 510.29 and formula C19H15Cl2F2NO7S for precise dosing and calculations.
- Available in small-scale packages including 50 mg for preclinical studies.
- Stable when stored frozen; follow manufacturer storage recommendations.
eMolecules 129544-85-0 | Medchem Express | MIND4-19 | 5mg | 721434759 | HY-147233 | MFCD01614372 | 373.47 | C22H19N3OS
ChemScene | 222-Trifluoro-1-(4-(trifluoromethyl)phenyl)ethanol | 100mg | 712788673 | CS-0436388 | 150698-81-0 | MFCD16067901 | 244.136 | C9H6F6O
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eMolecules Pharmablock / 3-(4-iodophenoxy)benzoic acid / 25mg / 586151192 / PBU2299 / 0.000 / 1406352-85-9 / MFCD19551768 / 340.116 / C13H9IO3
Pharmablock / 3-(4-iodophenoxy)benzoic acid / 25mg / 586151192 / PBU2299 / 0.000 / 1406352-85-9 / MFCD19551768 / 340.116 / C13H9IO3
eMolecules 1643354-85-1 | Ambeed | Methyl 23-dichloroquinoxaline-5-carboxylate | 50mg | 600840331 | A435754 | MFCD27922608 | 257.07 | C10H6Cl2N2O2
Ambeed | 2-(Pyrrolidin-1-yl)pyrimidine-4-carboxylic acid hydrochloride | 100mg | 672838295 | A1496655 | 2361643-61-8 | 229.660 | C9H12ClN3O2
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Medchemexpress LLC Kansuinine A | 57701-86-7 | 99.81% | 730.75 | 10 MG
Kansuinine A inhibits IL-6-induced Stat3 activation and exhibits antiviral and anticancer activities. It is for research use only. This compound is soluble in DMSO at concentrations ≥ 100 mg/mL.
- Possesses antiviral and anticancer activity
- Inhibits IL-6-induced Stat3 activation
- Shows a survival effect on NGF-dependent mouse NIH/3T3 cells expressing TrkB (ED50 3.28 μg/mL) and TrkA (ED50 7.92 μg/mL)
- Available documentation includes: data sheet, COA, SDS, HNMR, RP-HPLC, MS, and handling instructions