Benzodiazepines
Enzo Life Sciences Clozapine, (50mg), CAS Number: 5786-21-0
Dopamine receptor and serotonin receptor antagonist. Dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors. Alternative Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine. Formula: C18H19ClN4. MW: 326.8. CAS Number: 5786-21-0. MI: 14: 2423. Purity: ≥99% (HPLC). Appearance: Yellow crystalline powder. Solubility: Soluble in DMSO (30mg/ml) or dilute aqueous acid. Long Term Storage: +4°C
TARGETMOL CHEMICALS INC Coelenterazine h 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Coelenterazine H is a synthetic derivative of coelenterazine (a light-emitting biomolecule).Coelenterazine h (CLZN-h) is more sensitive to Ca 2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca 2+ concentrations. Purity 99.49%
Medchemexpress LLC Clozapine | 5786-21-0 | MFCD00153785 | C18H19ClN4 | 10MG
Clozapine reference standard (CAS 5786-21-0) provided as a certified solid for laboratory research and analytical use. Intended for method development, calibration, and quality control, this material is formulated to support accurate identity confirmation and quantitative assays in HPLC, LC-MS, and related analytical workflows.
- Intended for research and analytical applications.
- Suitable as a reference standard for method development and calibration.
- Supplied as a solid powder in small, certified pack sizes.
- Compatible with HPLC and LC-MS workflows.
- Provides traceable identity linked to CAS 5786-21-0.
Medchemexpress LLC Coelenterazine h (2-deoxycoelenterazine) | 50909-86-9 | 99.4% | 407.46 | C26H21N3O2 | 10 MG
Coelenterazine h (2-deoxycoelenterazine) is a yellow to orange solid luminescent substrate used in biochemical and cell-based assays. It functions as a substrate for Renilla luciferase, offers increased sensitivity to Ca2+ for detecting small calcium changes, and is supplied with high purity; the compound is unstable in solution and should be prepared fresh and stored protected from light at -20°C.
- Is a luminescent substrate for Renilla luciferase, enabling bioluminescent assays.
- Shows increased sensitivity to Ca2+, aiding detection of small calcium changes.
- Supplied as a yellow to orange solid with high purity (≈99.4%).
- Exhibits excitation/emission at 437/466 nm for assay matching.
- Is unstable in solution; prepare fresh solutions and store at -20°C protected from light.
Gold Biotechnology Inc Coelenterazine 10 mg
Coelenterazine is a luminophore found in aquatic organisms and is the substrate for many luciferase enzymes, including Renilla reniformis, Gaussia and aequorins. It is commonly used for bioluminescent calcium detection and the monitoring of reporter genes in BRET (Bioluminescence Resonance Energy Transfer), ELISA and HTS methods as well as chemiluminescent detection of superoxide anions and peroxynitrite in cells or tissues.
Apexbio Technology LLC Clozapine N-oxide (CNO) 34233-69-7 10mM (in 1mL DMSO)
Clozapine N-oxide (CNO CAS 34233-69-7) is a metabolic derivative of the atypical antipsychotic drug clozapine primarily known for its applications as a chemogenetic actuator Biologically inert in typical mammalian systems CNO selectively activates engineered muscarinic receptors such as the M3-designer receptors exclusively activated by designer drugs (DREADDs) Additionally CNO influences receptor expression levels exposure in cortical neuron cultures reduces 5-HT2 receptor density significantly Due to its specificity CNO is extensively utilized in neuroscience research to modulate neuronal activity non-invasively through chemogenetic approaches
Apexbio Technology LLC Clozapine N-oxide (CNO) 34233-69-7 5mg
Clozapine N-oxide (CNO CAS 34233-69-7) is a metabolic derivative of the atypical antipsychotic drug clozapine primarily known for its applications as a chemogenetic actuator Biologically inert in typical mammalian systems CNO selectively activates engineered muscarinic receptors such as the M3-designer receptors exclusively activated by designer drugs (DREADDs) Additionally CNO influences receptor expression levels exposure in cortical neuron cultures reduces 5-HT2 receptor density significantly Due to its specificity CNO is extensively utilized in neuroscience research to modulate neuronal activity non-invasively through chemogenetic approaches
Apexbio Technology LLC Coelenterazine 55779-48-1 5mg
Coelenterazine (CAS 55779-48-1) is a small molecule substrate for bioluminescent enzymes that generates a chemiluminescent signal upon oxidation by reactive oxygen species (ROS) particularly superoxide anions and peroxynitrite In rat hepatocytes it exhibits an IC50 of approximately 69 M toward superoxide anions Coelenterazine demonstrates concentration-dependent antioxidant activity enhancing cell viability and decreasing lipid peroxidation under oxidative stress induced by tert-butyl hydroperoxide It is widely applied in biomedical research including ELISA bioluminescence resonance energy transfer (BRET) high-throughput screening (HTS) and in vivo imaging studies of ROS in cancer models
Medchemexpress LLC Clozapine | 5786-21-0 | MFCD00153785 | ≥98.0% | 326.82 g/mol | C18H19ClN4 | 5 MG
Clozapine (Standard) is an analytical reference standard of clozapine (CAS 5786-21-0) intended for laboratory use in method development, calibration, and quality control. It provides a characterized sample for assay verification and instrumental calibration in pharmaceutical and research settings.
- Used as an analytical reference standard for assay calibration.
- Suitable for method validation and quality control.
- High purity (≥98.0%) for reliable analytical results.
- Molecular weight 326.82 g/mol and formula C18H19ClN4 for identification.
- Supplied as a small, accurately weighed quantity for analytical workflows.
Apexbio Technology LLC Clozapine 5786-21-0 10mM (in 1mL DMSO)
Clozapine (CAS 5786-21-0) is an atypical antipsychotic agent extensively studied for treating schizophrenia refractory to standard antipsychotics Clozapine exhibits high affinity binding to serotonin receptors 5-HT1c and 5-HT2 with reported pKi values of 8 07 and 7 63 respectively Additionally clozapine interacts with multiple dopamine receptor subtypes (D1-D5) displaying Ki values of 141 nM (D1) 80 nM (D2) 230 nM (D3) 89 nM (D4) and 250 nM (D5) Due to its distinctive receptor affinity profile clozapine serves as an important pharmacological tool in research on serotonin- and dopamine-mediated signaling mechanisms in psychiatric disorders
Medchemexpress LLC FAUC 365 5mg | 474432-66-1 | 462.44 g/mol | C23H25Cl2N3OS | 5 MG
FAUC 365 is a research-grade small molecule that acts as a highly selective dopamine D3 receptor antagonist (CAS 474432-66-1). It is supplied as a high-purity solid and is used in biochemical and pharmacological studies related to dopaminergic signaling.
- Highly selective D3 receptor antagonist with sub-nanomolar affinity (Ki ≈ 0.5 nM)
- High purity (~98.75%), suitable for in vitro assays
- Available as a solid and as a 10 mM solution in DMSO for convenience
- Off-white to light yellow solid, stable under recommended storage
- Intended for neuroscience research, including schizophrenia and Parkinson's disease models
Medchemexpress LLC Clozapine N-oxide dihydrochloride | 2250025-93-3 | MFCD00210190 | 10 MG
Clozapine N-oxide dihydrochloride is the dihydrochloride salt of clozapine N-oxide, a metabolite of clozapine commonly used as a selective agonist for designer receptors exclusively activated by designer drugs (DREADDs). The compound is provided as a research reagent for neuroscience and pharmacology studies; the salt form improves aqueous solubility compared with the free base and is intended for experimental use in vitro and in vivo.
- Activates DREADD receptors hM3Dq and hM4Di.
- Dihydrochloride salt with improved aqueous solubility.
- Molecular formula: C18H21Cl3N4O.
- Molecular weight: 415.74.
- CAS number: 2250025-93-3.
- Intended for research applications in neuroscience and pharmacology.
- Provided in small research quantities for experimental use.
Medchemexpress LLC N-ethyl-N-oxido-dodecan-1-amine | 1643-20-5 | MFCD00002049 | 98.0% | 229.40 g/mol | C14H31NO | 5 G
N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant supplied as a research-grade reagent for laboratory and formulation use. It functions as a detergent, emulsifier, and wetting agent and is suitable for formulation studies, analytical work, and life-science research. Typical specifications include 98.0% purity, molecular formula C14H31NO, molecular weight 229.40 g/mol, and CAS 1643-20-5; available in a 5 g pack.
- High-purity reagent for research and analytical applications.
- Acts as a detergent, emulsifier, and wetting agent.
- Suitable for formulation and laboratory studies.
- Documented specification available: SDS, COA, data sheet, and H NMR.
- Packaged for laboratory use in a 5 G vial.