Benzothiadiazoles

Organic heterocyclic compounds that consist of a benzene fused with a thiadiazole ring; thiadiazoles have a five-membered ring that contains two nitrogen atoms, one sulfur atoms, and two double bonds.

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eMolecules 4-IODO-2,1,3-BENZOTHIADIAZOLE | 352018-95-2 | 1G | Purity: 95%

AstaTech | 4-IODO-2,1,3-BENZOTHIADIAZOLE | 1G | 352018-95-2 | MFCD02681904

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Pricing & Availability

Chemscene ChemScene | 4,7-Dibromo-2,1,3-benzothiadiazole | 10G | CS-W002651 | 0.98 | 15155-41-6| MFCD00658844 | 293.97

ChemScene | 4,7-Dibromo-2,1,3-benzothiadiazole | 10G | CS-W002651 | 0.98 | 15155-41-6| MFCD00658844 | 293.97

Pricing & Availability

Apexbio Technology LLC KD 5170 940943-37-3 10mM (in 1mL DMSO)

KD 5170 (CAS 940943-37-3) is a small-molecule inhibitor targeting histone deacetylases (HDACs) enzymes that catalyze the removal of acetyl groups from histones repressing transcription KD 5170 inhibits HDAC enzyme activity exhibiting distinct inhibitory potency against HDAC isoforms HDAC1 HDAC2 HDAC3 HDAC4 and HDAC6 (IC50 values 0 020 2 0 0 075 0 026 and 0 014 M respectively) In vitro KD 5170 promotes dose-dependent histone hyperacetylation (EC50 25 nM in HeLa cells) and enhances p21WAF1 expression and -tubulin acetylation in HCT-116 cells It has demonstrated antitumor effects reducing tumor growth and increasing histone acetylation in HCT-116 and H929 tumor xenograft mouse models validating its utility in cancer research