Benzoxazines
TARGETMOL CHEMICALS INC RO5-3335 10MG
Also available in 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Ro5-3335 (CBF(beta)-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 uM). Ro5-3335 represses RUNX1/CBF(beta)-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBF(beta). Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro. purity: 99%
TARGETMOL CHEMICALS INC NESBUVIR 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons. purity: 98%
TARGETMOL CHEMICALS INC JAK3-IN-14 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JAK3-IN-14 is a potent selective and orally active FLT3 inhibitor with IC50s of ∼40 8 and 4 nM for FLT3-WT FLT3-D835Y and FLT3-D835H respectively. purity: 98%
TARGETMOL CHEMICALS INC RIDAFOROLIMUS 25MG
Also available in 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR) which may result in cell cycle arrest and consequently the inhibition of tumor cell growth and proliferation. Upregulated in some tumors mTOR is a serine/threonine kinase involved in regulating cellular proliferation motility and survival that is located downstream of the PI3K/Akt signaling pathway. purity: 98%
TARGETMOL CHEMICALS INC A-674563 2HCL552325-73-2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM modest potent to PKA and >30-fold selective for Akt1 over PKC.
TARGETMOL CHEMICALS INC UPADACITINIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM. purity: 99%
Medchemexpress LLC Diethylamino hydroxybenzoyl hexyl benzoate | 302776-68-7 | 99.9% | 397.51 | 1 ML
Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) is a photostable UV-A absorber. It is intended for research use only. It absorbs UV-A radiation with a peak at 354 nm, with a molar absorption coefficient in EtOH at 25°C of 39,000 mol/dm³/cm at 354 nm. Its emission spectrum in EtOH is dependent on the excitation wavelength.
- Photostable UV-A absorber
- Absorbs UV-A radiation at 354 nm
- Molar absorption coefficient: 39,000 mol/dm³/cm at 354 nm in EtOH at 25°C
- Emission spectrum in EtOH is excitation wavelength dependent
eMolecules Pharmablock 1H 2H 3H 4H 6H 7H 8H-[1 3]diazino[1 2-a]pyrimidine 50mg 551225156 PB92647 0 000 5807-14-7 MFCD00043003 139 202 C7H13N3
Pharmablock 1H 2H 3H 4H 6H 7H 8H-[1 3]diazino[1 2-a]pyrimidine 50mg 551225156 PB92647 0 000 5807-14-7 MFCD00043003 139 202 C7H13N3
Medchemexpress LLC 7-Ethoxyresorufin (resorufin ethyl ether) | 5725-91-7 | 99.6% | 1 MG
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1. It also inhibits NO synthase.
- Reduces the relaxant actions of acetylcholine in endothelium-intact rings and of NO, GTN, and SNP in endothelium-denuded rings in a concentration-dependent manner.
- Reacts with NADPH in the presence of acid to form a product that fluoresces at the same wavelength as Resorufin.
Medchemexpress LLC Gallocyanine chloride | 1562-85-2 | 92.0% | 5 MG
Gallocyanine chloride is a synthetic blue dyestuff used in research for Alzheimer's disease and related neurodegenerative tauopathies. It inhibits DKK1/LRP6 interaction and activates the Wnt signaling pathway.
- Activates the Wnt signaling pathway
- Causes β-catenin accumulation
- Exhibits anti-metastasis, anti-inflammatory, and anti-fibrosis activities
- Can serve as a fluorescent probe for detecting superoxide anion radicals
TARGETMOL CHEMICALS INC RITUXIMAB 5MG
Also available in 1 mg 10 mg and bulk. Please contact Fisher for quotes. Rituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM. purity: 98%
TARGETMOL CHEMICALS INC ZEAXANTHIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. 1. Lutein and Zeaxanthin (All-Trans-Zeaxanthin) in neural tissue may have biological effects that include antioxidation anti-inflammation and structural actions. 2. Lutein and Zeaxanthin may be protective against eye disease because they absorb damaging blue light that enters the eye. purity: 99%
Medchemexpress LLC 7-Ethoxyresorufin (Resorufin ethyl ether) | 5725-91-7 | 99.6% | 25 MG
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1. It also exhibits inhibitory effects on NO synthase. This product is intended for research use only and is not sold to patients.
- Fluorometric substrate for cytochrome P450, especially CYP1A1.
- Competitive inhibitor of cytochrome P450, particularly CYP1A1.
- Inhibits NO synthase.
Medchemexpress LLC Gallocyanine (chloride) | 1562-85-2 | 92.0% | 25 MG
Gallocyanine chloride is a synthetic blue dyestuff being investigated as a potential agent for Alzheimer's disease and related neurodegenerative tauopathies. It functions by inhibiting DKK1/LRP6 interaction with an IC50 of 6.38 μM, which in turn activates the Wnt signaling pathway and leads to β-catenin accumulation. This compound also demonstrates anti-metastasis, anti-inflammatory, and anti-fibrosis activities. Additionally, Gallocyanine chloride can be employed as a fluorescent probe for detecting superoxide anion radicals.
- Potential research agent for Alzheimer's disease and neurodegenerative tauopathies
- Inhibits DKK1/LRP6 interaction
- Activates Wnt signaling pathway
- Causes β-catenin accumulation
- Exhibits anti-metastasis activity
- Exhibits anti-inflammatory activity
- Exhibits anti-fibrosis activity
- Can be used as a fluorescent probe for superoxide anion radical detection