Benzoxazines
TARGETMOL CHEMICALS INC H-1152 DIHYDROCHLORIDE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA PKC PKG Aurora A and CaMKII with IC50 values of 3.03 uM 5.68 uM 0.360 uM 0.745 uM and 0.180 uM respectively. purity: 98%
TARGETMOL CHEMICALS INC SQ609 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives. SQ609 showed significant anti-tuberculous activity in mouse macrophages in vitro[1]. purity: 99%
TARGETMOL CHEMICALS INC IL-4-INHIBITOR-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 uM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 uM). It is selective for IL-4 over IL-13 (EC50= 18.2 uM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 uM) indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. purity: 98%
TARGETMOL CHEMICALS INC RBPJ INHIBITOR-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RBPJ Inhibitor-1 (RIN1) (RIN1) the RBPJ inhibitor blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1]. purity: 99%
TARGETMOL CHEMICALS INC TOTROMBOPAG 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Totrombopag (SB559448) is a candidate compound for action on RSV polymerase. purity: 98%
TARGETMOL CHEMICALS INC MORRONISIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells by inhibiting hyperglycemia and oxidative stress. Morroniside can notably protect the brain from damage induced by focal cerebral ischemia which might be related to morroniside antioxidant and anti-apoptotic properties in the brain. purity: 99%
TARGETMOL CHEMICALS INC KRIBB11 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor. purity: 99%
TARGETMOL CHEMICALS INC VRT-325 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers. purity: 98%
TARGETMOL CHEMICALS INC MIRANSERTIB 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Miransertib (ARQ-092) is an orally bioavailable selective and potent allosteric Akt inhibitor. purity: 99%
TARGETMOL CHEMICALS INC IMPORTAZOLE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Importazole is an inhibitor of the nuclear transport receptor importin-(beta). purity: 99%
TARGETMOL CHEMICALS INC REMOGLIFLOZIN ETABONATE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95 2.14 8.57 and 43.1uM for hSGLT2 rSGLT2 rSGLT1 and hSGLT1 respectively. purity: 99%
TARGETMOL CHEMICALS INC NAFETOLOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Nafetolol (K 5407) is a biochemical reagent that can be used to synthesize other compounds. purity: 98%
TARGETMOL CHEMICALS INC ML192 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits (beta)-arrestin transport ERK1/2 phosphorylation and PKC(beta)II translocation. purity: 99%
TARGETMOL CHEMICALS INC RABEXIMOD 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by stimulating TLR2 and TLR4 downstream to block the activation of inflammatory cells most likely macrophages. Rabeximod effectively reduces brain antigen presentation in mice during anti-inflammatory therapy for traumatic brain injury. purity: 100%
TARGETMOL CHEMICALS INC GYPENOSIDE XVII 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Gypenoside XVII (Gynosaponin S) confers protection against A(beta)25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways activation of Nrf2/ARE/HO-1 and inactivation of GSK-3(beta) pathways. purity: 99%