Benzoxazines
AdipoGen Ferutinin high purity
Chemical. CAS 41743-44-6. Formula C22H30O4. MW 358.5. Semisynthetic. Potent, naturally occuring non-steroid estrogenic compound. Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore mPTP. Strong agonist for estrogen receptor ERalpha and agonist/antagonist for ERbeta. Calcium ionophoretic Apoptosis modulator. Antiproliferative. Increases nitric oxide synthase activity and phosphoinositides breakdown in nervous tissue. Shows aphrodisiac and anti-sexual impotence activities. Anti-osteoporotic. Prevents osteoporosis caused by severe estrogen deficiency. Modest AChE inhibitor.
AdipoGen Ectoine
Natural chemical product. CAS 96702-03-3. Formula C6H10N2O2. MW 142.2. Isolated from halophilic bacteria Halomonas elongata. The ectoines belong to the class of compatible solutes also called extremolytes osmolytes from extremophiles. Extremolytes stabilize biological structures and macromolecules such as lipid membranes and proteins against a variety of stress factors, including high temperature, freeze-thaw cycles, drying and degradation. These very stable, non-toxic, animal-free protective agents are powerful additives in various Life Science applications, ranging from cryoprotection of animal cells over protein storage to PCR. They are protective osmolytes selected by nature for stabilization of all proteins in the cell against denaturing environmental stress without altering their functional activity. The stabilizing effect is based on the fact, that the protective osmolytes are strong water-structure formers and as such are preferentially excluded from the protein surface.
AdipoGen ZnAF-1F DA
Chemical. Formula C38H30F2N4O7. MW 692.66. Synthetic. For application to living cells, the diacetyl derivative of ZnAF-1F, ZnAF-1F DA, was synthesized. ZnAF-1F DA can permeate through the cell membrane, and is hydrolyzed by esterase in the cytosol to yield ZnAF-1F, which is retained in the cells. ZnAF-1F DA has been used to measure the changes of intracellular Zn2 in cultured cells and hippocampal slices. Spectral data lambdaex 492nm lambdaem 514nm in PBS.
AdipoGen Resorufin benzyl ether
Chemical. CAS 87687-02-3. Formula C19H13NO3. MW 303.31. Resorufin benzyl ether 7-Benzyloxyresorufin is a fluorogenic substrate widely used for monitoring cytochrome P450 CYP450 activities in cell extracts and solutions. It is the model substrate for 7-Benzoxyresorufin-O-dealkylase BROD assays. It is typically used near its apparent Km value of 30 �M to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 CYPs have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Benzyloxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin lambdaex=571nm, lambdaem=585nm.
AdipoGen Resorufin methyl ether
Chemical. CAS 5725-89-3. Formula C13H9NO3. MW 227.22. Synthetic. Substrate for Cytochrome P-450. Used for various investigations including the differentiatiation of cytochrome P-450 isozymes.
AdipoGen NBD-PZ
Chemical. CAS 139332-66-4. Formula C10H11N5O3. MW 249.23. Synthetic. Fluorescent reagent for the determination of mono- and diisocyantes in air samples, and determination of lactate, hydroxybutyrate and other intermediates in body fluids. The piperazino moiety reacts readily with isocyantes to form the corresponding urea-derivatives. The derivatives can be detected by LC with UV or fluorescent-detection. Used for visualizing lysosomes in living cells also.
AdipoGen Oenanthacid-4-CF3-umbellifer
Chemical. CAS 351002-79-4. Formula C17H17F3O4. MW 342.31. Synthetic. Suitable as fluorogenic substrate for lipases.
AdipoGen Neocuproine hemihydrate
Chemical. CAS 484-11-7. Formula C14H12N2 . 0.5H2O. MW 217.27. Neocuproine is a complexing reagent, known for its ability to form stable complexes with metal ions, particularly CU2 ions. This property makes it valuable in various analytical and research applications, including spectrophotometry and electrochemistry. In the presence of CU2 ions, neocuproine forms a brightly colored complex that can be used for the quantitative determination of copper in solution. The Neocuproine-CU2 complex exists in a 21 ratio with a maximum absorption at 454 nm. Neocuproine is used in complex with Cu2 as chromogenic oxidant in the total antioxidant capacity assay CUPRAC method. In addition to its analytical uses, neocuproine and its derivatives have been employed in the field of coordination chemistry to study and synthesize metal complexes.
AdipoGen NBD-PZ
Chemical. CAS 139332-66-4. Formula C10H11N5O3. MW 249.23. Synthetic. Fluorescent reagent for the determination of mono- and diisocyantes in air samples, and determination of lactate, hydroxybutyrate and other intermediates in body fluids. The piperazino moiety reacts readily with isocyantes to form the corresponding urea-derivatives. The derivatives can be detected by LC with UV or fluorescent-detection. Used for visualizing lysosomes in living cells also.
AdipoGen Meranzin
Chemical. CAS 23971-42-8. Formula C15H16O4. MW 260.29. Meranzin is a bioactive compound from the Traditional Chinese Medicine TCM Chaihu-Shugan-San CSS. Meranzin exhibits anti-inflammatory, analgesic and antibacterial activity. Meranzin regulates the alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression.
AdipoGen GE81112 A B
Chemical. CAS 883726-13-4 GE81112A, 883726-14-5 GE81112B. Formula C24H34ClN9O10 A, C24H35ClN10O10 B. MW 644.0 A659.1 B. Isolated from Strepomyces sp. Tetrapeptide antibiotic. Potent and selective inhibitor of bacterial protein synthesis. Translational inhibitor specific for the initiation phase. Binds to the 30S ribosomal subunit and specifically inhibits P-site decoding of the mRNA initiation codon by the fMet-tRNA anticodon. Inhibits in vivo protein synthesis but not other cell functions such as DNA duplication, transcription and cell wall synthesis. Antibacterial activity against some Gram-positive and Gram-negative bacteria. Unique scaffold for designing new drugs.
ILEX LIFE SCIENCES LLC 3-D LIFE HYLINK 3 X 200 UL
3-D Life HyLink, thiol-modified hyaluronic acid, hydrogel crosslinker component (3 x 200 ul). INTRO: 3-D Life technology, manufactured in Germany by Cellendes GmbH, is an integrated system for generation of hydrogels used in 3D cell culture. 3-D Life represents the most flexible system for biomimetic hydrogel design. DESCRIPTION: 3-D Life HyLink molecule consists of hyaluronic acid (hyaluronan) carrying thiol groups along its backbone. When combined with 3-D Life SG-Polymers, thiol groups on HyLink form stable thioether bonds with the thiol-reactive groups on the polymers, which results in the formation of the hydrogel. HyLink can be used with 3-D Life functionalized polymers SG-PVA and SG-Dextran. APPLICATION: 3-D Life HyLink is used together with thiol-reactive SG-Polymers of the 3-D Life Hydrogel system to establish 3-D cell cultures. QUANTITY: Sufficient for 5 ml hydrogel of a crosslinking strength of 1.2 mmol/l when used with SG-Polymers of the 3-D Life Hydrogel system.
ILEX LIFE SCIENCES LLC GELACELL GELATIN INSERT 24WELL
Gelacell - Gelatin scaffold inserts for 24-well plate 3D cell culture (24 pack). INTRO: Gelacell, manufactured by Gelatex Technologies, is a unique, 3D microfibrous scaffold specifically engineered for advanced in vitro 3D cell culture and tissue engineering applications. Gelacell offers exceptional biocompatibility and non-toxicity across many cell types. DESCRIPTION: Specially designed 24-well plate scaffold “inserts” made from pharmaceutical grade gelatin offer cell culture conditions for short-to-medium durations. Perfectly tailored for the cultivation of complex systems like cell microenvironments, tissue regeneration, and organoids, Gelacell also makes a robust platform for drug screening and other cell culture investigations. The optimized design of the scaffold ensures thermal, chemical, and mechanical stability, while also providing substantial swelling capabilities and porosity, allowing efficient nutrient diffusion and thereby preventing cellular waste build up.
ILEX LIFE SCIENCES LLC GELACELL PLGA INSERTS 24WELL
Gelacell - PLGA scaffold inserts for 24-well plate 3D cell culture (24 pack). INTRO: Gelacell, manufactured by Gelatex Technologies, is a unique, 3D microfibrous scaffold specifically engineered for advanced in vitro 3D cell culture and tissue engineering applications. Designed as a non-woven, highly porous scaffold, Gelacell offers exceptional biocompatibility and non-toxicity across a variety of cell types. DESCRIPTION: Specially designed 24-well plate scaffold “inserts” made from pharmaceutical grade poly lactic-co-glycolic acid (PLGA) offer cell culture conditions for short-to-medium durations. Perfectly tailored for the cultivation of complex systems like cell microenvironments, tissue regeneration, and organoids. The optimized design ensures thermal, chemical, and mechanical stability, while also providing substantial swelling capabilities and porosity, allowing efficient nutrient diffusion and thereby preventing cellular waste build up.
ILEX LIFE SCIENCES LLC GELACELL PLGA CELLCROWN 6WELL
Gelacell - PLGA scaffolds fixed to cell crowns in 6-well plate for 3D cell culture (1 plate). INTRO: Gelacell, manufactured by Gelatex Technologies, is a unique, 3D microfibrous scaffold specifically engineered for advanced in vitro 3D cell culture and tissue engineering applications. DESCRIPTION: This variant of Gelacell is specially designed for medium-to-long term cell culture durations. Scaffolds made from pharmaceutical grade poly lactic-co-glycolic acid (PLGA) are fixed to cell crowns in a 6-well plate. The cell crowns act as Boyden chambers for facilitating studies related to air-liquid interface culture, co-culture, complex tissue models, etc. Gelacell also makes a robust platform for drug screening and other cell culture investigations. The optimized design ensures thermal, chemical, and mechanical stability, while also providing substantial swelling capabilities and porosity, allowing efficient nutrient diffusion and thereby preventing cellular waste build up.