Benzoxazines
Medchemexpress LLC Gallocyanine (chloride) | 1562-85-2 | 92.0% | 25 MG
Gallocyanine chloride is a synthetic blue dyestuff being investigated as a potential agent for Alzheimer's disease and related neurodegenerative tauopathies. It functions by inhibiting DKK1/LRP6 interaction with an IC50 of 6.38 μM, which in turn activates the Wnt signaling pathway and leads to β-catenin accumulation. This compound also demonstrates anti-metastasis, anti-inflammatory, and anti-fibrosis activities. Additionally, Gallocyanine chloride can be employed as a fluorescent probe for detecting superoxide anion radicals.
- Potential research agent for Alzheimer's disease and neurodegenerative tauopathies
- Inhibits DKK1/LRP6 interaction
- Activates Wnt signaling pathway
- Causes β-catenin accumulation
- Exhibits anti-metastasis activity
- Exhibits anti-inflammatory activity
- Exhibits anti-fibrosis activity
- Can be used as a fluorescent probe for superoxide anion radical detection
Medchemexpress LLC 7-Ethoxyresorufin (resorufin ethyl ether) | 5725-91-7 | 99.6% | 1 MG
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1. It also inhibits NO synthase.
- Reduces the relaxant actions of acetylcholine in endothelium-intact rings and of NO, GTN, and SNP in endothelium-denuded rings in a concentration-dependent manner.
- Reacts with NADPH in the presence of acid to form a product that fluoresces at the same wavelength as Resorufin.
Medchemexpress LLC Resorufin-β-D-galactopyranoside | 95079-19-9 | 98.32% | 375.33 | 50 MG
Resorufin-β-D-galactopyranoside is a substrate for β-galactosidase, an enzyme crucial for lactose metabolism and gene expression regulation. It is frequently employed in various biochemical assays to assess β-galactosidase activity. This compound is hydrolyzed by β-galactosidase to form resorufin, a red fluorescent product, serving as an effective tool for detecting and quantifying enzyme activity in biological samples, including bacteria and mammalian cells. It is intended for research use only as a biochemical reagent for life science-related research.
- Used as a substrate for β-galactosidase activity assays
- Enables detection and quantification of β-galactosidase activity
- Forms resorufin, a red fluorescent product, upon hydrolysis
- Suitable for use in biological samples, including bacteria and mammalian cells
- Intended for research use only
Medchemexpress LLC Phenoxazine | 135-67-1 | MFCD00005014 | 99.9% | 183.21 | 10 G
Phenoxazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
- Used as a biochemical reagent
- Suitable for life science related research
- For research use only
- Not sold to patients
Medchemexpress LLC Resorufin | 635-78-9 | MFCD00128991 | 98.9% | 213.19 g/mol | C12H7NO3 | 10MG
Resorufin is a highly fluorescent pink dye used as a probe for detecting reactive oxygen species (ROS) and reactive nitrogen species (RNS) in biochemical and cell-based assays. It exhibits red-shifted absorption and emission and is supplied as a solid for laboratory use.
- Highly fluorescent dye suitable for ROS and RNS detection.
- Water-soluble with red-shifted absorption and emission properties.
- Applicable as a fluorescent standard or probe in enzyme and cell assays.
- Supplied as a solid with brown to black appearance for convenient storage.
- Stable when stored protected from light; follow recommended storage conditions.
- Available in small research quantities suitable for assay development.
AdipoGen Resorufin pentyl ether
Chemical. CAS 87687-03-4. Formula C17H17NO3. MW 283.32. Resorufin pentyl ether 7-Pentoxyresorufin is a fluorogenic substrate used for monitoring cytochrome P450 CYP450 activities in cell extracts and solutions. It is used as substrate for 7-Pentoxyresorufin-O-dealkylase PROD assays. It is used to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 CYPs have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Pentoxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin lambdaex=571nm, lambdaem=585nm. Resorufin pentyl ether shows also antibacterial properties.
Medchemexpress LLC Diethylamino hydroxybenzoyl hexyl benzoate | 302776-68-7 | 99.9% | 397.51 | 1 ML
Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) is a photostable UV-A absorber. It is intended for research use only. It absorbs UV-A radiation with a peak at 354 nm, with a molar absorption coefficient in EtOH at 25°C of 39,000 mol/dm³/cm at 354 nm. Its emission spectrum in EtOH is dependent on the excitation wavelength.
- Photostable UV-A absorber
- Absorbs UV-A radiation at 354 nm
- Molar absorption coefficient: 39,000 mol/dm³/cm at 354 nm in EtOH at 25°C
- Emission spectrum in EtOH is excitation wavelength dependent
Abcam Cinnabarinic acid, Endogenous mGlu4 selective agonist, 50MG
MW 300.22 Da, Purity >98%. Endogenous selective mGlu4 agonist; generated by autoxidation of the tryptophan metabolite 3-hydroxyanthranilic acid. Activates mGlu4 receptors in transiently transfected HEK293 cells, and is devoid of activity on other mGlu receptor subtypes (mGlu1, 2, 5, 6, 7, and 8). Protects against NMDA-induced excitotoxic cell death.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Resorufin benzyl ether
Chemical. CAS 87687-02-3. Formula C19H13NO3. MW 303.31. Resorufin benzyl ether 7-Benzyloxyresorufin is a fluorogenic substrate widely used for monitoring cytochrome P450 CYP450 activities in cell extracts and solutions. It is the model substrate for 7-Benzoxyresorufin-O-dealkylase BROD assays. It is typically used near its apparent Km value of 30 �M to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 CYPs have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Benzyloxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin lambdaex=571nm, lambdaem=585nm.
eMolecules BENZYL 10H-PHENOXAZINE-10-CARBOXYLATE | 1407632-07-8 | MFCD25563252 | 1g
AstaTech | BENZYL 10H-PHENOXAZINE-10-CARBOXYLATE | 1g | 308518682 | 79690 | 95.000 | 1407632-07-8 | MFCD25563252 | 317.344 | C20H15NO3
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Medchemexpress LLC Resorufin-β-D-galactopyranoside | 95079-19-9 | 98.3% | 375.33 | 1 MG
Resorufin-β-D-galactopyranoside serves as a substrate in various biochemical assays, enabling the measurement of β-galactosidase activity. This enzyme is crucial for lactose metabolism and gene expression regulation. The compound's unique properties allow it to be hydrolyzed by β-galactosidase, yielding a red fluorescent product called resorufin. This makes it an effective tool for detecting and quantifying β-galactosidase activity in biological samples like bacteria or mammalian cells. It is intended for life science research use only.
- Substrate in biochemical assays
- Measures β-galactosidase activity
- Hydrolyzed to form a red fluorescent product (resorufin)
- Detects and quantifies β-galactosidase activity
- Suitable for biological samples
- For research use only
eMolecules 6-Dimethylamino-pyridine-2-carboxylic acid | 30721-88-1 | MFCD13188975 | 5g
J & W PharmLab LLC | 6-Dimethylamino-pyridine-2-carboxylic acid | 5g | 289355231 | 69R0605 | 97.000 | 30721-88-1 | MFCD13188975 | 166.180 | C8H10N2O2
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Abcam Resorufin, 20MG
MW 213.19 Da. Stable red fluorophore probe. Widely used in cell labeling and Amplex Red type enzyme assays. It represents the reduced dye formed from Amplex Red reaction or resazurin reductions. Unstable in the presence of thiols such as dithiothreitol (DTT) and 2-mercaptoethanol.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Resorufin ethyl ether
Chemical. CAS 5725-91-7. Formula C14H11NO3. MW 241.24. Synthetic. Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.
eMolecules 2-(DIETHYLAMINO)-2-METHYLPROPAN-1-OL | 25688-63-5 | MFCD22421580 | 1g
AstaTech | 2-(DIETHYLAMINO)-2-METHYLPROPAN-1-OL | 1g | 449721611 | 27917 | 95.000 | 25688-63-5 | MFCD22421580 | 145.246 | C8H19NO
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