Biotin and derivatives
Medchemexpress LLC BHQ-2 NHS | 916753-62-3 | 97.7% | 603.58 | 100 MG
BHQ-2 NHS | 916753-62-3 | 97.7% | 603.58 | 100 MG
Apexbio Technology LLC DMG-PEG2000-NHS(Synonyms: DMG-PEG2000-NHS ester, NHS-PEG2000-DMG, DMG PEG NHS ester), 500mg.
DMG-PEG2000-NHS is a polyethylene glycol (PEG) derivative functionalized with an N-hydroxysuccinimide (NHS) ester The reactive NHS ester readily forms stable amide linkages upon interaction with primary amine (-NH ) groups facilitating covalent attachment to peptides proteins or amino-functionalized small molecules Due to these conjugation properties DMG-PEG2000-NHS is commonly employed in biomedical research for constructing drug delivery platforms such as lipid nanoparticles (LNPs) or liposomes particularly for siRNA delivery systems
Medchemexpress LLC BHQ-2 NHS | 916753-62-3 | 97.7% | 603.58 | 50 MG
BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. It has a wide and intense quenching range from 560-670 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications with orange to far-red emitting dyes. The NHS ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
- Dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester.
- Wide and intense quenching range from 560-670 nm.
- Useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes.
- NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Medchemexpress LLC Sulfo-NHS-Biotin sodium | 194041-65-1 | 95.0% | 443.43 Da | 100 MG
Sulfo-NHS-Biotin sodium is a low-molecular-weight tracer (443.4 Da) that is used to assess blood-brain barrier permeability. It functions as a passive tracer in animal models of traumatic brain injury, helping to measure blood-brain barrier leakage volume without exhibiting inherent pharmacodynamic effects.
- Low-molecular-weight (443.4 Da) tracer
- Assesses blood-brain barrier permeability
- Functions as a passive tracer
- No inherent pharmacodynamic effects
- Suitable for research use
![eMolecules 1204834-00-3 | Azido-PEG8-NHS ester | Broadpharm | MFCD13184949 | 564.589 | C23H40N4O12 | 97.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 208940019](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000129977.jpg-250.jpg)
eMolecules 1204834-00-3 | Azido-PEG8-NHS ester | Broadpharm | MFCD13184949 | 564.589 | C23H40N4O12 | 97.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 208940019
Azido-PEG8-NHS ester | Broadpharm | 1204834-00-3 | MFCD13184949 | 564.589 | C23H40N4O12 | 97.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 208940019
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 25 MG
Bis-PEG21-NHS ester is a PEG/alkyl/ether-based linker used in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is supplied as a solid with high purity and defined storage recommendations.
- PEG/alkyl/ether-based linker
- Cleavable linker suitable for ADC synthesis
- Used in the construction of PROTAC molecules
- High purity (98.0%)
- Molecular weight 1237.34 g/mol
- CAS number 2221948-98-5
- Powder storage: -20°C for long-term stability
Medchemexpress LLC Azido-PEG6-NHS ester | 2055014-64-5 | MFCD22683276 | 98.0% | 476.48 g/mol | C19H32N4O10 | 25 MG
Azido-PEG6-NHS ester is a bifunctional PEG-based reagent containing an azide group for bioorthogonal click chemistry and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines. It is commonly used as a linker in antibody-drug conjugate and PROTAC synthesis, and for general bioconjugation applications.
- Bifunctional: azide for CuAAC/SPAAC and NHS ester for amine coupling.
- PEG6 spacer improves solubility and reduces steric hindrance.
- High purity for reliable conjugation reactions.
- Suitable for ADC and PROTAC linker installation and bioconjugation workflows.
- Available in small-scale packaging compatible with research applications.
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 250 MG
Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two different ligands connected by a linker: one ligand for an E3 ubiquitin ligase and the other for the target protein.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of two different ligands connected by a linker
- White to off-white solid appearance
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-NHS (DSPE-NHS) | 1383932-86-2 | MFCD34561791 | 95.0% | 945.2 g/mol | C49H89N2O13P | 10 MG
DSPE-NHS is an N-hydroxysuccinimide (NHS) ester functionalized distearoyl phosphoethanolamine used for bioconjugation and liposome formation. The reagent self-assembles into lipid bilayers in aqueous solution, and the NHS ester reacts selectively with primary amines to form stable amide bonds, enabling antibody labeling and attachment of amine-containing molecules for nanoparticle and drug-delivery applications.
- Reactive NHS ester for covalent coupling to primary amines.
- Self-assembles into lipid bilayers in aqueous solution.
- Enables antibody labeling and protein conjugation.
- Suitable for liposome and nanocarrier preparation.
- Long-term storage recommended at -20 °C, sealed and protected from moisture and light.
Medchemexpress LLC Heneicosaoxa PEG diacid bis(2,5-dioxo-1-pyrrolidinyl) ester | 2221948-98-5 | MFCD21363289 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 100 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG)-based N-hydroxysuccinimide (NHS) ester linker used for amine conjugation in the synthesis of PROTACs and antibody-drug conjugates. It provides hydrophilicity and spacing between conjugated moieties.
- Bifunctional NHS ester for amine conjugation.
- PEG21 spacer provides hydrophilicity and flexibility.
- Suitable for PROTAC and ADC linker assembly.
- High purity: 98.0%.
- Molecular weight ~1237.34 g/mol.
- Solid powder; store powder at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in lab-scale quantities such as 100 MG.
Medchemexpress LLC Biotin methyl ester 250mg
Biotin methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research
eMolecules 58-85-5 | D-(+)-Biotin | Apollo Scientific US | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10g | 705605965
D-(+)-Biotin | Apollo Scientific US | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10g | 705605965
![Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 3-((2-(((((1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-yl)methoxy)carbonyl)amino)... | 95.0% | 454.56 g/mol | C20H26N2O6S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203370.png-250.jpg)
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 3-((2-(((((1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-yl)methoxy)carbonyl)amino)... | 95.0% | 454.56 g/mol | C20H26N2O6S2 | 10 MG
BCN-SS-NHS is a cleavable linker reagent containing an NHS ester and a strained bicyclo[6.1.0]nonyne (BCN) moiety. It is used for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and to introduce a cleavable disulfide-containing linker arm in bioconjugation and antibody-drug conjugate synthesis.
- Used for SPAAC click chemistry
- Contains an NHS ester for efficient amine coupling
- Includes a disulfide-cleavable linker for intracellular release
- Suitable for antibody-drug conjugate and bioconjugation workflows
- Available in small-scale research quantities
Medchemexpress LLC m-PEG15-NHS ester | 98.0% | 100 MG
m-PEG15-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. These Proteolysis Targeting Chimeras consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound has a molecular weight of 875.99 and a chemical formula of C39H73NO20. It appears as a white to off-white solid below 35°C and a liquid above 35°C.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Molecular weight: 875.99
- Chemical formula: C39H73NO20
- Appears as a white to off-white solid below 35°C
- Liquid above 35°C
- Store at -20°C in sealed storage, away from moisture and light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C