Biotin and derivatives
Medchemexpress LLC m-PEG8-NHS ester | 756525-90-3 | MFCD13184969 | 95.0% | 509.54 g/mol | C22H39NO12 | 100 MG
m-PEG8-NHS ester is a methoxy polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester functional group. It provides an eight-unit PEG spacer for conjugation to primary amines and is used in antibody-drug conjugate (ADC) synthesis and general bioconjugation to increase solubility and reduce aggregation.
- Non-cleavable 8-unit PEG spacer
- Amine-reactive NHS ester for conjugation
- Supplied as a 100 mg vial (research use only)
- Purity by NMR: 95.0%
- Molecular weight 509.54 g/mol; formula C22H39NO12
- Store pure material at -20°C for long-term stability
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated to biotin | 133695-76-8 | MFCD01961045 | 97.5% | 974.36 | C51H96N3O10PS | 50 MG
DSPE-Biotin is a biotinylated phospholipid used as a lipid reagent for biochemical research, liposome formulation, and surface functionalization of nanoparticles. It enables biotin-mediated capture or labeling of lipid assemblies and supports drug-delivery and biochemical assay applications. Store cold and protect from light for best stability.
- Biotinylated phospholipid enabling strong biotin-avidin interactions.
- Suitable for liposome preparation and nanoparticle surface functionalization.
- Facilitates biotin-mediated capture and labeling of lipid assemblies.
- High purity (97.5%) for reproducible experimental results.
- Solid, off-white to light yellow appearance for easy handling.
- Storage: -20°C; in solvent: -80°C (6 months), -20°C (1 month); protect from light.
Medchemexpress LLC Mal-PEG6-NHS ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 g/mol | C23H34N2O12 | 1 G
Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a maleimide reactive group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied for research use in synthesis and bioconjugation workflows.
- Purity 98.0%.
- Cas number 1599472-25-9.
- Molecular weight 530.52 g/mol.
- Chemical formula C23H34N2O12.
- Soluble in DMSO at 100 mg/mL (in vitro; ultrasonic recommended).
- Suggested in vivo formulations provided for dosing preparations.
- For research use only; not for use in patients.
- Pack quantity 1 G.
Medchemexpress LLC (S,E)-TCO-NHS ester | 1610931-22-0 | MFCD24386372 | ≥98.0% | 267.28 g/mol | C13H17NO5 | 10 MG
TCO-NHS ester (axial) is a trans-cyclooctene N-hydroxysuccinimide ester used as an amine-reactive building block for bioorthogonal conjugation. It enables rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine partners and is suitable for labeling or modifying amine-containing small molecules and biomolecules in organic media. The reagent is supplied as a purified solid with supporting analytical documentation for research use.
- Amine-reactive NHS ester for efficient conjugation.
- Fast bioorthogonal iEDDA reactivity with tetrazines.
- Suitable for labeling and bioconjugation of biomolecules.
- High purity for reproducible experimental results.
- Analytical documentation available (SDS, COA, H-NMR).
Medchemexpress LLC m-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g·mol⁻¹ | C18H31NO10 | 50 MG
m-PEG6-NHS ester is a non-cleavable 6-unit polyethylene glycol (PEG) linker terminating in an activated N-hydroxysuccinimide (NHS) ester; it is used for amide coupling to amines in the synthesis of antibody-drug conjugates and PROTACs.
- Purity: ≥97.0%.
- Molecular weight: 421.44 g·mol⁻¹.
- Chemical formula: C18H31NO10.
- CAS number: 1449390-12-8.
- Form: liquid, colorless to light yellow; density ~1.21 g/cm³.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Applications: non-cleavable PEG6 linker for ADC synthesis; PEG/alkyl/ether-based PROTAC linker.
- Packaging: commonly available in 100 MG, 250 MG, 1 G, and 5 G; larger quantities available by quote; a 50 MG pack is indicated in supplier data but on the manufacturer page.
Medchemexpress LLC DBCO-N-bis(PEG4-NHS ester) | 2639395-38-1 | 96.2% | 995.03 | C49H62N4O18 | 5 MG
DBCO-N-bis(PEG4-NHS ester) is a PEG-based bifunctional linker that contains two PEG4-NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. It is designed for bioconjugation and protein labeling via NHS-ester chemistry and for copper-free click conjugation with azide-containing partners through strain-promoted alkyne-azide cycloaddition (SPAAC).
- Contains two PEG4-NHS ester groups and a DBCO functional group.
- Enables protein modification through NHS-ester conjugation to primary amines.
- Supports copper-free SPAAC click chemistry with azide partners.
- Suitable for small-scale research use; available in 5 mg and larger sizes.
- Molecular weight 995.03; CAS number 2639395-38-1.
Medchemexpress LLC Biotin-oxytocin (biotin-a-hypophamine; biotin-oxytocic hormone) | 99.3% | 1233.48 | C53H80N14O14S3 | 10 MG
Biotin-oxytocin is an N-terminally biotinylated form of the oxytocin peptide supplied for laboratory research use. The peptide retains the native disulfide-stabilized backbone while providing an N-terminal biotin tag for affinity capture, labeling, and detection in biochemical and cell-based assays. Supplied with supporting documentation including a datasheet and COA.
- 99.3% purity.
- Molecular weight 1233.48 Da.
- Sequence: biotin-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide Cys1-Cys6).
- Available sizes: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg.
- Supplied with datasheet, COA, and SDS.
- Intended for research use only.
Medchemexpress LLC Biotin-TEG-ATFBA | 1264662-85-2 | MFCD13184978 | 99.1% | 663.68 | C27H37F4N7O6S | 10 MG
Biotin-TEG-ATFBA is a biotin-labeled click chemistry reagent containing a perfluorophenylazide group. Upon photolysis it forms a stable azene intermediate that participates in insertion and cycloaddition reactions, enabling bioconjugation and linker construction for research applications. The compound is supplied as a solid with high purity and is intended for laboratory use.
Medchemexpress LLC N-(NHS ester-PEG2)-N-bis(PEG3-azide) | 99.9% | 704.73 | C28H48N8O13 | 10 MG
N-(NHS ester-PEG2)-N-bis(PEG3-azide) is a bifunctional polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester and two terminal azide groups. It is supplied as a high-purity reagent for bioconjugation and click chemistry applications, enabling amine-reactive coupling and subsequent azide-alkyne cycloaddition.
- Reactive N-hydroxysuccinimide (NHS) ester for conjugation to primary amines.
- Two terminal azide groups for copper-catalyzed or strain-promoted click chemistry.
- Compact PEG spacer improves solubility and reduces steric hindrance.
- High purity (99.90%) suitable for research applications.
- Typical appearance: liquid; molecular weight 704.73 Da; formula C28H48N8O13.
- Store sealed at -20°C, protected from moisture and light.
- Available in small mg-scale quantities for research use.
Medchemexpress LLC Dbco-NHCO-S-S-NHS ester | 96.0% | 565.66 | C28H27N3O6S2 | 10 MG
DBCO-NHCO-S-S-NHS ester is a cleavable linker used for assembling antibody-drug conjugates and for bioconjugation via strain-promoted alkyne-azide cycloaddition (SPAAC). It provides an NHS ester for amine coupling and a disulfide cleavable spacer for payload release.
- Molecular weight 565.66.
- Chemical formula C28H27N3O6S2.
- Purity approximately 96.0%.
- Physical form: solid, white to off-white.
- Contains a DBCO moiety for SPAAC click chemistry.
- Features an activated NHS ester for amine conjugation.
- Disulfide spacer provides cleavable linkage for payload release.
- Storage: powder at -20°C; in solvent at -80°C (6 months) or -20°C (1 month).
![Medchemexpress LLC 2,5-Pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | 95.0% | 356.28 g/mol | C14H16N2O9 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202007.png-250.jpg)
Medchemexpress LLC 2,5-Pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | 95.0% | 356.28 g/mol | C14H16N2O9 | 5 G
Bis-PEG1-NHS ester is a non-cleavable, short polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester groups. It is used to couple agents to primary amines via stable amide bond formation, providing a hydrophilic spacer that improves solubility and spacing in bioconjugates.
- Non-cleavable 1-unit PEG spacer.
- Two NHS ester groups for amine-reactive conjugation.
- Forms stable amide bonds with primary amines.
- Increases aqueous solubility of conjugates.
- Suitable for antibody-agent conjugation and general bioconjugation workflows.
Medchemexpress LLC Azido-PEG3-SS-NHS | 95.0% | 436.50 | C15H24N4O7S2 | 5 MG
Azido-PEG3-SS-NHS is a cleavable three-unit polyethylene glycol (PEG) linker intended for bioconjugation and antibody-drug conjugate synthesis. It contains an azide for click chemistry, a disulfide bond for reductive cleavage, and an N-hydroxysuccinimide (NHS) ester for amine coupling.
- Contains azide for copper-catalyzed and strain-promoted click reactions.
- Contains NHS ester for efficient conjugation to primary amines.
- Includes a cleavable disulfide spacer for intracellular release.
- Suitable for linker design in ADC, PROTAC, and other bioconjugation workflows.
- Supplied as a liquid, colorless to light yellow, with reported purity of 95.0%.
Medchemexpress LLC Rhodamine B NHS ester | 144700-55-0 | 96.9% | 576.08 | C32H34ClN3O5 | 10 MG
Rhodamine B NHS ester is an N-hydroxysuccinimide (NHS) activated fluorescent dye for covalent labeling of primary amines in proteins, peptides, and other biomolecules. It forms stable amide bonds to introduce a rhodamine fluorophore for fluorescence microscopy, flow cytometry, and biochemical assays.
- NHS-activated for efficient and selective amine coupling.
- Bright rhodamine fluorescence suitable for microscopy and flow cytometry.
- Molecular weight 576.08 g/mol and formula C32H34ClN3O5.
- High purity (~96.9%) for reliable labeling performance.
- Available in small research pack sizes for convenient use.