Biotin and derivatives
6-Biotinamidohexanoic Acid 97.0+%, TCI America™
CAS: 72040-64-3 Molecular Formula: C16H27N3O4S Molecular Weight (g/mol): 357.469 MDL Number: MFCD00144853 InChI Key: CMUGHZFPFWNUQT-HUBLWGQQSA-N Synonym: N-Biotinyl-6-aminohexanoic Acid, N-(5-Carboxypentyl)biotinamide PubChem CID: 446905 IUPAC Name: 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoic acid SMILES: C1C2C(C(S1)CCCCC(=O)NCCCCCC(=O)O)NC(=O)N2
(+)-Biotin N-succinimidyl ester, 98%
CAS: 35013-72-0 Molecular Formula: C14H19N3O5S Molecular Weight (g/mol): 341.382 MDL Number: MFCD00078531 InChI Key: YMXHPSHLTSZXKH-RVBZMBCESA-N Synonym: +-biotin n-hydroxysuccinimide ester,biotin-nhs,biotin nhs,2,5-dioxopyrrolidin-1-yl 5-3as,4s,6ar-2-oxohexahydro-1h-thieno 3,4-d imidazol-4-yl pentanoate,n-hydroxysuccinimidobiotin,d-biotinyl-osu,biotin-osu,n-succinimidyl d-biotinate,bhse,biotin n-hydroxysuccinimide ester PubChem CID: 6710714 IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate SMILES: C1CC(=O)N(C1=O)OC(=O)CCCCC2C3C(CS2)NC(=O)N3
![N-Succinimidyl N-[6-(Biotinamido)hexanoyl]-6-aminohexanoate 90.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-89889-52-1.jpg-250.jpg)
N-Succinimidyl N-[6-(Biotinamido)hexanoyl]-6-aminohexanoate 90.0+%, TCI America™
CAS: 89889-52-1 Molecular Formula: C26H41N5O7S Molecular Weight (g/mol): 567.70 MDL Number: MFCD00467154 InChI Key: ATYCFNRXENKXSE-UHFFFAOYNA-N Synonym: N-[6-(Biotinamido)hexanoyl]-6-aminohexanoic Acid N-Succinimidyl Ester, Biotin-LC-LC-NHS PubChem CID: 16219024 IUPAC Name: 2,5-dioxopyrrolidin-1-yl 6-[6-(5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanamido)hexanamido]hexanoate SMILES: O=C(CCCCCNC(=O)CCCCC1SCC2NC(=O)NC12)NCCCCCC(=O)ON1C(=O)CCC1=O
N-Succinimidyl 6-Biotinamidohexanoate 97.0+%, TCI America™
CAS: 72040-63-2 Molecular Formula: C20H30N4O6S Molecular Weight (g/mol): 454.542 MDL Number: MFCD00065502 InChI Key: UVGHPGOONBRLCX-NJSLBKSFSA-N Synonym: 6-Biotinamidohexanoic Acid N-Succinimidyl Ester, N-[5-(N-Succinimidyloxycarbonyl)pentyl]biotinamide, N-Biotinyl-6-aminohexanoic Acid Succinimidyl Ester PubChem CID: 83874 IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate SMILES: C1CC(=O)N(C1=O)OC(=O)CCCCCNC(=O)CCCCC2C3C(CS2)NC(=O)N3
D-Biotin, MP Biomedicals
CAS: 58-85-5 Molecular Formula: C10H16N2O3S Molecular Weight (g/mol): 244.31 MDL Number: MFCD00005541 InChI Key: YBJHBAHKTGYVGT-UHFFFAOYNA-N Synonym: biotin,d-biotin,vitamin h,coenzyme r,vitamin b7,bios ii,factor s,bioepiderm,d +-biotin,biodermatin PubChem CID: 171548 ChEBI: CHEBI:15956 IUPAC Name: 5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanoic acid SMILES: OC(=O)CCCCC1SCC2NC(=O)NC12
Apexbio Technology LLC Azidobutyric acid NHS ester 50mg
Azidobutyric acid NHS ester is a chemical reagent used to introduce azide functional groups onto biomolecules containing primary amines It is designed to enable the covalent modification of proteins peptides or amino-modified nucleotides facilitating subsequent copper-catalyzed azide-alkyne click chemistry reactions Azidobutyric acid NHS ester exerts its utility by forming stable amide bonds with amino groups under mild aqueous conditions thus providing an azide handle for bioorthogonal labeling Based on these properties Azidobutyric acid NHS ester holds research potential in applications such as bioimaging flow cytometry protein profiling affinity purification and drug conjugation research
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 100 MG
Biotin-PEG4-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are compounds with two ligands connected by a linker; one binds to an E3 ubiquitin ligase, and the other targets a specific protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Can be utilized in the synthesis of protacs
- Has a purity of 97.0%
- Appears as a white to off-white solid
- Intended for research use only
Medchemexpress LLC Biotin-PEG8-acid | 2143964-62-7 | 99.8% | C29H53N3O12S | 50 MG
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Appears as a white to off-white solid
- Molecular weight: 667.81
Medchemexpress LLC Biotin-PEG8-acid | 2143964-62-7 | 99.8% | C29H53N3O12S | 100 MG
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled, PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG3-acid 1g | 252881-76-8 | 447.55 | C19H33N3O7S | 1 G
Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker used to introduce a biotin tag with a short PEG3 spacer in PROTAC synthesis and bioconjugation workflows. The material is supplied as a 1 g purified solid (typical purity 98.0%) with molecular weight 447.55 g/mol and chemical formula C19H33N3O7S, and is accompanied by a batch-specific certificate of analysis.
- Provides a biotin handle separated by a PEG3 spacer to reduce steric hindrance
- Designed for incorporation into PROTACs and other bioconjugates
- Improves aqueous solubility compared with direct biotinylation
- Typically supplied with batch certificate showing ~98.0% purity
- Solid form with known molecular weight and formula for formulation planning
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 100 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker. This chemical reagent is used in the synthesis of PROTACs and is intended for research use only. It appears as a colorless to light yellow liquid.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Designed for selective degradation of target proteins
- Consists of two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase, the other to the target protein
Medchemexpress LLC Undecanoic acid, biotinyl N-hydroxysuccinimide ester | 887628-40-2 | MFCD05865045 | 99.5% | C25H40N4O6S | 10MG
Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that provides an NHS-activated biotinylation reagent for conjugation to primary amines. It is intended for research use in chemical synthesis and bioconjugation workflows, enabling introduction of a biotin affinity tag for purification and detection; follow the manufacturer datasheet and COA for handling and storage instructions.
- NHS-activated ester for efficient amine coupling.
- 10-carbon spacer to reduce steric hindrance during binding.
- Introduces a biotin tag for affinity purification and detection.
- High purity suitable for synthetic and analytical applications.
- Supplied with datasheet and certificate of analysis for quality verification.
Medchemexpress LLC 3-Pyrrolidinesulfonic acid, 1-(acetyloxy)-2,5-dioxo- | 152305-87-8 | 98.0% | C6H7NO7S | 25 MG
Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs are compounds containing two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
- Relevant to cancer research
- Relevant to cancer targeted therapy
- Classified as a PROTAC linker
- Functions as an inhibitor
Medchemexpress LLC Butanoic acid NHS ester (BHQ-1) | 916753-61-2 | 95.4% | 601.61 g/mol | C30H31N7O7 | 10 MG
BHQ-1 NHS is an N-hydroxysuccinimide (NHS) ester derivative of a non-fluorescent quencher designed for covalent coupling to primary amines on nucleotides, oligonucleotides, and other biomolecules. It is intended for use as a quencher in fluorescence probe and assay design and for direct labeling of fluorescently labeled nucleotides. For research use only.
- Reactive NHS ester for stable amide bond formation with amines.
- Non-fluorescent quenching suitable for fluorescence-based assays.
- High purity, typically 95.44% as stated on the COA.
- Soluble in DMSO at approximately 4.35 mg/mL; ultrasonic agitation recommended.
- Provided in milligram quantities for small-scale labeling workflows.
Medchemexpress LLC 4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64-Heneicosaoxaheptahexacontanedioic acid, 1,67-bis(2,5-dioxo-1-pyrrolidinyl) ester | 2221948-98-5 | 99.89% | 250 MG
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker that can be utilized in the synthesis of PROTACs. It also serves as a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Can be used in the synthesis of PROTACs.
- Serves as a cleavable ADC linker.