Cycloheptathiophenes
Medchemexpress LLC Fumarate hydratase-I 100mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Medchemexpress LLC Dofequidar (fumarate) | 153653-30-6 | 98.0% | 597.66 | 100 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. It competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, thereby increasing drug concentration in cancer cells and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC Vonoprazan Fumarate (TAK-438) | 881681-01-2 | MFCD18633280 | C21H20FN3O6S | 1 ML
Vonoprazan Fumarate (TAK-438) is a potent and orally active potassium-competitive acid blocker (P-CAB) developed for research into acid-related diseases such as gastroesophageal reflux disease and peptic ulcer disease. It functions as a proton pump inhibitor (PPI) and exhibits antisecretory activity.
- Potent and orally active potassium-competitive acid blocker (P-CAB)
- Proton pump inhibitor (PPI)
- Antisecretory activity
- Inhibits H+,K+-ATPase activity with an IC50 of 19 nM at pH 6.5
TARGETMOL CHEMICALS INC IBUTILIDE FUMARATE 100MG
Also available in 10 mg 25 mg 50 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow inward predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval. purity: 99%
Medchemexpress LLC Monomethyl fumarate-d3 | 1616345-41-5 | MFCD34469902 | 99.0% | 133.117 g/mol | C5H3D3O4 | 1 MG
Monomethyl fumarate-d3 is the deuterium-labeled analogue of monomethyl fumarate, supplied as an isotopically labeled tracer and internal standard for analytical and pharmacokinetic studies. It is intended for research use in quantitative workflows where precise isotope labeling improves detection and quantitation.
- Isotopically labeled internal standard for NMR, GC-MS, and LC-MS.
- Useful as a tracer in pharmacokinetic and metabolic profiling.
- High analytical purity (≈99.0%).
- Provided in small research quantities suitable for analytical assays.
- Molecular formula C5H3D3O4; CAS 1616345-41-5.
Apexbio Technology LLC Fesoterodine Fumarate 286930-03-8 1g
Fesoterodine Fumarate (CAS 286930-03-8) is a synthetic antimuscarinic agent that acts as a competitive antagonist at muscarinic acetylcholine receptors particularly the M3 subtype in the bladder detrusor muscle By inhibiting these receptors the compound modulates involuntary bladder contractions reducing symptoms associated with overactive bladder syndrome such as urgency and frequency Fesoterodine Fumarate is utilized in biomedical research to study cholinergic signaling mechanisms involved in urinary function and to explore pharmacological interventions targeting muscarinic pathways in urological disorders
Medchemexpress LLC Fumarate hydratase-IN-2 sodium salt | 2070009-45-7 | MFCD00218071 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 50 MG
Fumarate hydratase-IN-2 sodium salt is a cell-permeable, competitive inhibitor of fumarate hydratase with a reported Ki of 4.5 μM. Supplied as a sodium salt solid, it is intended for biochemical and cellular studies probing fumarate hydratase activity and nutrient-dependent cytotoxicity.
- Cell-permeable competitive inhibitor of fumarate hydratase.
- Reported Ki 4.5 μM for fumarate hydratase.
- Molecular formula C25H25N2NaO4; molecular weight 440.47 g/mol.
- High purity (98.7%) in solid form.
- Available in multiple sizes, including 50 mg and 10 mM/1 mL solution.
Medchemexpress LLC Iron(II) fumarate (Ferrous fumarate) | 141-01-5 | 95.1% | 500 MG
Iron(II) fumarate is an orally effective active dietary supplement. It can alleviate metabolic damage and damage to silkworms caused by cypermethrin and can be used for research on iron deficiency anemia.
- Orally effective active dietary supplement.
- Can alleviate metabolic damage and damage to silkworms caused by cypermethrin.
- Can be used for research on iron deficiency anemia.
- In vitro, can restore metabolic pathway disruption caused by cypermethrin, enhance the tolerance and cell viability of BmN cells to cypermethrin.
- In vivo, can alleviate the damage of cypermethrin to silkworms.
- In vivo, can alter the intestinal morphology and microbiota of Yellow River carp, promoting the development of intestinal villi and increasing the thickness of the intestinal muscle layer.
Cayman Chemical Monmethyl fumarate 250g
An active metabolite of dimethyl fumarate; an agonist of HCA2/GPR109A (EC50 = 9.4 µM); reduces neutrophil adhesion to endothelial cells stimulated with TNF, decreases CXCL2-directed neutrophil migration, and increases the expression of the Nrf2 target gene NQO1 in wild-type but not HCA2-/- macrophages; inhibits proliferation and induces differentiation in keratinocytes, as well as decreases TPA-induced levels of TNF-α in keratinocytes at 1 mM; reduces symptoms of EAE in mice at 1 mg/day