Cycloheptathiophenes
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 5 MG
Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic agent. It acts as a potent blocker of the rapidly activating delayed rectifier K⁺ current (IKr) in AT-1 cells. This compound is intended for research use only.
- Potent IKr blocker with an EC50 value of 20 nM in AT-1 cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as HERG alone.
- Prolongs cardiac repolarization in vitro and in vivo.
- Appears as a white to off-white solid.
- Recommended storage for solid: 4°C, sealed, away from moisture.
- Recommended storage in solvent: -80°C for 6 months, or -20°C for 1 month.
Medchemexpress LLC Ketotifen fumarate | 34580-14-8 | 99.9% | 25 MG
Ketotifen fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro. This compound also exhibits antiviral activity against SARS-CoV-2 and Influenza virus, making it useful in research for autoimmune encephalomyelitis (EAE) and the prevention of asthma attacks.
- Acts as an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker
- Functions as a mast cell stabilizer
- Blocks 6-phosphogluconate dehydrogenase (PGD) in vitro
- Exhibits antiviral activity against SARS-CoV-2 and influenza virus
- Useful for research related to autoimmune encephalomyelitis (EAE)
- Applied in the prevention of asthma attacks research
Medchemexpress LLC Ketotifen | 34580-13-7 | 99.7% | 100 MG
Ketotifen (HC 20-511) is an orally active, second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro and demonstrates antiviral activity against SARS-CoV-2 and Influenza virus, making it suitable for various research applications.
- Orally active compound
- Functions as a second-generation noncompetitive histamine 1 (H1) receptor blocker
- Acts as a mast cell stabilizer
- Blocks 6-phosphogluconate dehydrogenase (PGD) in vitro
- Demonstrates antiviral activity against SARS-CoV-2
- Demonstrates antiviral activity against Influenza virus
- Used in research for autoimmune encephalomyelitis (EAE)
- Used in research for asthma attack prevention
Medchemexpress LLC Monoethyl fumarate | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 g/mol | C6H8O4 | 100 G
Monoethyl fumarate is the monoethyl ester of fumaric acid, supplied as a powder for laboratory research. It functions as an NRF2 activator and is used as a preservative and polymerization agent in macromolecular material studies. For research use only; not for human consumption.
- 99.6% purity.
- Molecular weight 144.13 g/mol.
- Molecular formula C6H8O4.
- Off-white powder form.
- Used as an NRF2 activator and polymerization preservative.
- Store powder at -20°C for up to 3 years.
Apexbio Technology LLC Dimethyl Fumarate 624-49-7 5g
Dimethyl fumarate (CAS 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway It is designed to promote Nrf2 nuclear translocation and induce transcription of antioxidant response genes thereby modulating oxidative stress response pathways Dimethyl fumarate exerts its biological activity primarily through activation of Nrf2-mediated antioxidant gene expression In cell-based assays dimethyl fumarate demonstrates Nrf2 activation activity with an IC50 value of approximately 5 M Based on these pharmacological properties dimethyl fumarate holds research potential in the study of oxidative stress inflammation and related pathophysiological processes
Apexbio Technology LLC Formoterol fumarate 43229-80-7 50mg
Formoterol fumarate (CAS 43229-80-7) is a long-acting 2-adrenergic receptor agonist that selectively binds to 2-adrenergic receptors on bronchial smooth muscle inducing relaxation and bronchodilation Through this mechanism it modulates airway smooth muscle tone leading to sustained improvement in airflow This compound is widely utilized in research exploring pathways of bronchoconstriction receptor signaling and the pharmacological management of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD)
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 10mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC Ketotifen | 34580-13-7 | 99.7% | 10 MM * 1 ML
Ketotifen is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro and also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used for research on autoimmune encephalomyelitis (EAE) and asthma attack prevention.
- Orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer.
- Can block 6-phosphogluconate dehydrogenase (PGD) in vitro.
- Has antiviral activity against SARS-CoV-2 and influenza virus.
- Can be used for research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.
Medchemexpress LLC Ibutilide fumarate | 122647-32-9 | 99.69% | 10 MM 1 ML
Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Prolongs cardiac repolarization in vitro and in vivo
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone
- Cells expressing MDR1*7 show marked resistance to Ibutilide
Medchemexpress LLC Fumarate hydratase-IN-2 (sodium salt) | 2070009-45-7 | 98.7% | 440.47 | C25H25N2NaO4 | 100 MG
Fumarate hydratase-IN-2 (sodium salt) is a cell-permeable, competitive inhibitor of fumarate hydratase with a reported Ki of 4.5 μM and nutrient-dependent cytotoxicity. Supplied as a sodium salt, it is intended for biochemical and cell-based studies probing fumarate hydratase activity and related metabolic pathways.
- Cell-permeable, competitive inhibitor of fumarate hydratase (Ki = 4.5 μM).
- Reported nutrient-dependent cytotoxicity in cell assays.
- High purity suitable for research use (LCMS 98.7%).
- Molecular weight 440.47; formula C25H25N2NaO4.
- Available in small-scale solid quantities for assay preparation (for example, 100 mg).
Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 | 25 MG
VUF11207 fumarate is a CXCR7 agonist that specifically binds to CXCR7. It reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation. This product is for research use only.
- Specifically binds to CXCR7
- Reduces CXCL12-mediated osteoclastogenesis
- Inhibits bone resorption
- Suppresses phosphorylation of ERK
- Inhibits RANKL- and TNF-α-induced osteoclastogenesis
- Inhibits LPS-induced osteoclastogenesis and bone resorption
Medchemexpress LLC Tepilamide fumarate | 1208229-58-6 | 99.8% | 243.26 | 25 MG
Tepilamide fumarate is an oral fumaric acid ester that acts as a proagent of Monomethyl fumarate. It is used in the research of moderate to severe chronic plaque psoriasis and can also enhance the effectiveness of oncolytic viruses.
- Acts as a proagent of Monomethyl fumarate.
- Used in research for moderate to severe chronic plaque psoriasis.
- Can enhance the effectiveness of oncolytic viruses.
- Selectively promotes oncolytic virus infection in cancer cells without affecting healthy tissues.
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | 99.9% | 255.22 g/mol | C11H13NO6 | 1 ML
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in preclinical research to probe Nrf2 pathway modulation and multiple sclerosis-related biology. Supplied as a ready-to-use solution, it is intended for laboratory research use only and not for human or clinical applications.
- Ready-to-use 10 mM solution in DMSO for immediate experimental use.
- High purity (99.90%) suitable for biochemical and cellular assays.
- Molecular weight 255.22 g/mol, molecular formula C11H13NO6.
- Prodrug of monomethyl fumarate for Nrf2 pathway and MS-related research.
- Provided in a 1 mL volume for small-scale assays and dose-response studies.
- For research use only; not for human or clinical use.
Selleck Chemical LLC Zilurgisertib fumarate-5MG
Zilurgisertib fumarate(INCB-000928 fumarate NBU-928 fumarate) is a selective ALK 2 inhibitor It is under development for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva
Selleck Chemical LLC Zilurgisertib fumarate-25MG
Zilurgisertib fumarate(INCB-000928 fumarate NBU-928 fumarate) is a selective ALK 2 inhibitor It is under development for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva