Cycloheptathiophenes
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 1 ML
Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. This compound is intended for research use only and is not sold for patient treatment. It has demonstrated efficacy in reducing cholesterol synthesis and inducing apoptosis in various cancer cell lines, as well as inhibiting tumor growth in vivo.
- Inhibits Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM.
- Reduces cholesterol synthesis with an IC50 of approximately 1.5 nM in HepG2 cells.
- Significantly reduces viability of PC-3 prostate cancer cells.
- Induces apoptosis in LNCaP and C4-2 cell lines.
- Reduces AR protein expression and increases ERβ protein expression.
- Lowers LDL-C maximally by approximately 60% in hamsters.
- Significantly reduces in vivo tumor growth in mice.
Apexbio Technology LLC Bisoprolol fumarate 104344-23-2 10mM (in 1mL DMSO)
Bisoprolol fumarate (CAS 104344-23-2) is a selective 1-adrenergic receptor antagonist that preferentially inhibits 1-adrenergic signaling with minimal activity at 2 receptors By suppressing 1 receptor-mediated pathways it reduces both heart rate and myocardial contractility following oral administration The compound is utilized in pharmacological and physiological studies to investigate mechanisms underlying hypertension coronary artery disease and stable ventricular dysfunction as well as to evaluate therapeutic interventions that target sympathetic nervous system modulation in cardiovascular research contexts
Apexbio Technology LLC 3-Aminopropionitrile fumarate (2:1) 2079-89-2 500mg
3-Aminopropionitrile fumarate (2 1) (CAS 2079-89-2) is a small molecule derivative originally identified from Apocynaceae species It acts by inhibiting collagen cross-linking through interference with enzymatic pathways responsible for covalent bonding among collagen molecules Modulation of enzyme activity and signaling cascades by this compound leads to altered collagen stability within biological tissues Owing to its capacity to disrupt collagen maturation 3-Aminopropionitrile fumarate (2 1) serves as a valuable tool in studies of fibrotic disorders and related metabolic processes where aberrant extracellular matrix remodeling is implicated
Medchemexpress LLC Fesoterodine (fumarate) | 286930-03-8 | MFCD09835695 | ≥98% | 574.67 | 10 MG
Fesoterodine fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It is used for the overactive bladder (OAB).
- Orally active
- Nonsubtype selective
- Competitive muscarinic receptor (mAChR) antagonist
- Targets mAChR
- Used for overactive bladder (OAB)
- Research areas include neurological disease, metabolic disease, and cancer
Apexbio Technology LLC Clemastine Fumarate 14976-57-9 100mg
Clemastine Fumarate (CAS 14976-57-9) is a small molecule that functions as a selective antagonist of the histamine H1 receptor It demonstrates high affinity for the receptor with an inhibitory concentration (IC50) of 3 nM By blocking histamine H1 receptor-mediated signaling clemastine fumarate is utilized in research to study histaminergic pathways and allergic responses It is also employed to investigate the pharmacological modulation of H1 receptor activity in various cellular and in vivo models
Apexbio Technology LLC Clemastine Fumarate 14976-57-9 10mM (in 1mL DMSO)
Clemastine Fumarate (CAS 14976-57-9) is a small molecule that functions as a selective antagonist of the histamine H1 receptor It demonstrates high affinity for the receptor with an inhibitory concentration (IC50) of 3 nM By blocking histamine H1 receptor-mediated signaling clemastine fumarate is utilized in research to study histaminergic pathways and allergic responses It is also employed to investigate the pharmacological modulation of H1 receptor activity in various cellular and in vivo models
Medchemexpress LLC Rupatadine fumarate | 182349-12-8 | MFCD00926499 | 97.3% | 532.0 g/mol | C30H30ClN3O4 | 5 MG
Rupatadine fumarate is the fumarate salt of the antihistamine rupatadine provided as a laboratory reference standard for analytical testing and method development. The material is supplied in small, quantified packages with supporting documentation for quality control and safe handling.
Medchemexpress LLC Dofequidar (fumarate) | 153653-30-6 | 98.0% | 597.66 | 100 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. It competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, thereby increasing drug concentration in cancer cells and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC Dofequidar fumarate | 153653-30-6 | 98.0% | 597.66 | 50 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound.
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1).
- Highly potent reversing effect on multidrug-resistant tumor cells.
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1.
- Blocks the efflux of chemotherapeutic agents.
- Increases drug concentration in cancer cells.
- Enhances the chemotherapeutic effect.
Medchemexpress LLC Fumarate hydratase-I 50mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Fumarate hydratase-I 100mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Formoterol fumarate | 43229-80-7 | 99.8% | C19H24N2O4·1/2C4H4O4 | 5 MG
Formoterol fumarate is a selective β2-adrenoceptor agonist. It is used in research for chronic obstructive pulmonary disease and bronchial asthma, effectively relaxing acetylcholine-induced contraction in bronchioles. The compound has a molecular weight of 402.44 and a chemical formula of C19H24N2O4·1/2C4H4O4, appearing as a white to off-white solid.
- Selective β2-adrenoceptor agonist
- Used for research in chronic obstructive pulmonary disease and bronchial asthma
- Abolishes acetylcholine-induced contraction in bronchioles
- White to off-white solid appearance
- Soluble in DMSO (≥ 50 mg/mL)
- Store solid at 4°C, sealed, away from moisture
- Store in solvent at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture