Cycloheptathiophenes
![Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-40106-13-6.jpg-250.jpg)
Ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate, 96%
CAS: 40106-13-6 Molecular Formula: C12H17NO2S Molecular Weight (g/mol): 239.333 MDL Number: MFCD00216932 InChI Key: XTUHIGALMIGZST-UHFFFAOYSA-N Synonym: ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-4h,5h,6h,7h,8h-cyclohepta b thiophene-3-carboxylate,ethyl 2-amino-5,6,7,8-tetrahydro-4h-cyclohepta-b thiophene-3-carboxylate,ethyl 2-amino-4,5,6,7,8-pentahydrocyclohepta 1,2-b thiophene-3-carboxylate,2-amino-5,6,7,8-tetrahydro-4h-cyclohepta b thiophene-3-carboxylic acid ethyl ester,ethyl 2-aminocyclohepta b thiophene-3-carboxylate,aronis24232,ethyl 2-aminocycloheptathiophene-3-carboxylate,2-amino-3-ethoxy-carbonyl-4,5-pentamethylenethiophene PubChem CID: 292644 IUPAC Name: ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate SMILES: CCOC(=O)C1=C(SC2=C1CCCCC2)N
Ketotifen fumarate, 99%
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Ketotifen Hydrogen Fumarate, EP, 98.5-101%, Spectrum™ Chemical
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.50 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N IUPAC Name: (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-8-one SMILES: OC(=O)\C=C\C(O)=O.CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12
Pizotifen 98.0+%, TCI America™
CAS: 15574-96-6 Molecular Formula: C19H21NS Molecular Weight (g/mol): 295.444 MDL Number: MFCD00864192 InChI Key: FIADGNVRKBPQEU-UHFFFAOYSA-N Synonym: 4-[9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene]-1-methylpiperidine, Sandomigran PubChem CID: 27400 ChEBI: CHEBI:50212 IUPAC Name: 4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine SMILES: CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
Ketotifen Fumarate 98.0+%, TCI America™
CAS: 34580-14-8 Molecular Formula: C23H23NO5S Molecular Weight (g/mol): 425.499 MDL Number: MFCD00079394 InChI Key: YNQQEYBLVYAWNX-WLHGVMLRSA-N Synonym: ketotifen fumarate,zaditen,ketotifen hydrogen fumarate,alaway,unii-hbd503woro,hc 20,511 fumarate,ketotifen fumarate usan:jan,ketotifen fumarate salt,hbd503woro PubChem CID: 5282408 IUPAC Name: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | 99.9% | 255.22 g/mol | C11H13NO6 | 1 ML
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in preclinical research to probe Nrf2 pathway modulation and multiple sclerosis-related biology. Supplied as a ready-to-use solution, it is intended for laboratory research use only and not for human or clinical applications.
- Ready-to-use 10 mM solution in DMSO for immediate experimental use.
- High purity (99.90%) suitable for biochemical and cellular assays.
- Molecular weight 255.22 g/mol, molecular formula C11H13NO6.
- Prodrug of monomethyl fumarate for Nrf2 pathway and MS-related research.
- Provided in a 1 mL volume for small-scale assays and dose-response studies.
- For research use only; not for human or clinical use.
Medchemexpress LLC Dofequidar (fumarate) | 153653-30-6 | 98.0% | 597.66 | 5 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect.
- Orally active
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1
- Blocks the efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Apexbio Technology LLC (±)-Anatoxin A fumarate 1219922-30-1 1mg
( )-Anatoxin A fumarate (CAS 1219922-30-1) is a naturally occurring alkaloid isolated from freshwater cyanobacteria It functions as an agonist at nicotinic acetylcholine receptors exhibiting high binding affinity for rat brain 4 2 (K i 1 25 nM) and lower affinity for 7 (K i 1 84 M) subtypes In functional assays ( )-Anatoxin A fumarate induces dopamine release in rat striatal synaptosomes with an EC 50 of 134 nM This compound is utilized in neuroscience research to investigate cholinergic signaling and dopaminergic mechanisms in the central nervous system
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | ≥98.0% | 255.23 g/mol | C11H13NO6 | 50 MG
Diroximel fumarate is supplied as a research-grade small-molecule reagent intended for laboratory studies. This listing represents a 50 MG pack of the prodrug of monomethyl fumarate and is provided for experimental and analytical use in research settings; it is not for clinical or human use.
- For research use only, not for human or clinical use.
- Supplied as a small 50 MG pack suitable for laboratory testing.
- High purity, typically ≥98.0%.
- Molecular weight 255.23 g/mol and formula C11H13NO6.
- Useful for studies of fumarate metabolism and related biochemical pathways.
Apexbio Technology LLC Ro 60-0175 fumarate 169675-09-6 10mg
Ro 60-0175 fumarate (CAS 169675-09-6) is a selective agonist of the 5-HT2C serotonin receptor known to specifically activate serotonergic signaling pathways By targeting 5-HT2C receptors it modulates neurotransmitter release and neuronal circuitry influencing processes such as appetite regulation mood stabilization and cognitive function Ro 60-0175 fumarate is widely utilized in neuropharmacological research to investigate central nervous system mechanisms and to assess the pharmacological properties and therapeutic potential of 5-HT2C receptor agonists in models of depression anxiety obesity and related neuropsychiatric conditions
Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.
- Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
- Active against ovarian, breast, prostate, and cervical tumor cell lines.
- Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
- Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
- Active in vivo via i.v. and p.o. administration against human tumor xenografts.
- Shows dose-dependent antitumor activity in mouse xenograft models.
Apexbio Technology LLC Ro 60-0175 fumarate 169675-09-6 50mg
Ro 60-0175 fumarate (CAS 169675-09-6) is a selective agonist of the 5-HT2C serotonin receptor known to specifically activate serotonergic signaling pathways By targeting 5-HT2C receptors it modulates neurotransmitter release and neuronal circuitry influencing processes such as appetite regulation mood stabilization and cognitive function Ro 60-0175 fumarate is widely utilized in neuropharmacological research to investigate central nervous system mechanisms and to assess the pharmacological properties and therapeutic potential of 5-HT2C receptor agonists in models of depression anxiety obesity and related neuropsychiatric conditions
Medchemexpress LLC Fumarate hydratase-I 10mM 1mL
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 50mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections