Cycloheptathiophenes
Medchemexpress LLC Ibutilide fumarate | 122647-32-9 | 99.69% | 10 MM 1 ML
Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Prolongs cardiac repolarization in vitro and in vivo
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone
- Cells expressing MDR1*7 show marked resistance to Ibutilide
Medchemexpress LLC Fumarate hydratase-I 50mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Fumarate hydratase-I 25mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Fumarate hydratase-I 100mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Apexbio Technology LLC Ketotifen Fumarate 34580-14-8 1g
Ketotifen fumarate is a noncompetitive antagonist of histamine H1 receptors and functions additionally as a mast cell stabilizer It inhibits histamine-mediated allergic responses through preventing histamine receptor activation and limiting mast cell degranulation Its pharmacological activity involves suppression of calcium influx into mast cells thus inhibiting histamine release Ketotifen fumarate is extensively utilized in biomedical research focusing on allergy and asthma pathophysiology to assess mast-cell-mediated mechanisms and histamine signaling pathways In vitro studies report its IC50 values ranging approximately from 0 8 to 2 5 M depending on assay parameters and cell types This compound commonly serves as a pharmacological tool when investigating allergic inflammation asthma and histamine-dependent cellular events
Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 | 1 ML
VTP50469 fumarate is a highly selective and orally active Menin-MLL interaction inhibitor. It demonstrates potent anti-leukemia activity by targeting MLL-rearranged and NPM1-mutant leukemia. This compound is intended for research use only.
- Potently inhibits Menin-MLL interaction with a Ki of 104 pM.
- Inhibits cell proliferation in MLL-rearranged and ALL cell lines.
- Induces apoptosis in MLL-r B cell ALL cell lines.
- Promotes differentiation in MLL-r AML cell lines.
- Displaces Menin from protein complexes.
- Effective in in vivo models of leukemia, improving survival.
Medchemexpress LLC Fumarate hydratase-I 10mM 1mL
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Fumarate hydratase-I 1g
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Fumarate hydratase-I 10mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Apexbio Technology LLC Ketotifen Fumarate 34580-14-8 200mg
Ketotifen fumarate is a noncompetitive antagonist of histamine H1 receptors and functions additionally as a mast cell stabilizer It inhibits histamine-mediated allergic responses through preventing histamine receptor activation and limiting mast cell degranulation Its pharmacological activity involves suppression of calcium influx into mast cells thus inhibiting histamine release Ketotifen fumarate is extensively utilized in biomedical research focusing on allergy and asthma pathophysiology to assess mast-cell-mediated mechanisms and histamine signaling pathways In vitro studies report its IC50 values ranging approximately from 0 8 to 2 5 M depending on assay parameters and cell types This compound commonly serves as a pharmacological tool when investigating allergic inflammation asthma and histamine-dependent cellular events
Medchemexpress LLC 3aH-indole-3a-carboxylic acid, biphenyl-4-ylmethyl derivative, sodium salt | 2070009-45-7 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 25 MG
Fumarate hydratase-IN-2 sodium salt is a cell-permeable, competitive fumarate hydratase inhibitor (Ki = 4.5 μM) that exhibits nutrient-dependent cytotoxicity. Supplied as a white to off-white solid intended for research use, it is suitable for cell-based and biochemical studies of fumarate hydratase activity.
- Cell-permeable inhibitor effective in cell-based assays.
- Competitive inhibition with Ki = 4.5 μM for target engagement.
- High purity (98.7%) suitable for research applications.
- Soluble in DMSO and water with warming and sonication.
- Available in small solid quantities and solution formats for flexibility.
Medchemexpress LLC Fumarate hydratase-IN-2 (sodium salt) | 2070009-45-7 | 98.7% | 440.47 | C25H25N2NaO4 | 100 MG
Fumarate hydratase-IN-2 (sodium salt) is a cell-permeable, competitive inhibitor of fumarate hydratase with a reported Ki of 4.5 μM and nutrient-dependent cytotoxicity. Supplied as a sodium salt, it is intended for biochemical and cell-based studies probing fumarate hydratase activity and related metabolic pathways.
- Cell-permeable, competitive inhibitor of fumarate hydratase (Ki = 4.5 μM).
- Reported nutrient-dependent cytotoxicity in cell assays.
- High purity suitable for research use (LCMS 98.7%).
- Molecular weight 440.47; formula C25H25N2NaO4.
- Available in small-scale solid quantities for assay preparation (for example, 100 mg).
Medchemexpress LLC Dimethyl fumarate | 624-49-7 | 100.0% | 144.13 | 1 ML
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator that induces upregulation of antioxidant gene expression. It also induces necroptosis in colon cancer cells via the GSH depletion/ROS increase/MAPKs activation pathway, and promotes cell autophagy. Dimethyl fumarate is used for multiple sclerosis research.
- Orally active and brain-penetrant Nrf2 activator
- Induces upregulation of antioxidant gene expression
- Induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway
- Promotes cell autophagy
- Used for multiple sclerosis research
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 50 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent and a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM).
- Cells expressing MDR1*7 show resistance (IC50: 105.3 nM vs 27.4 nM).
- Prolongs cardiac repolarization in vitro and in vivo.
- Cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., 10-min infusion) resulted in polymorphic and monomorphic non-sustained ventricular tachycardia in animal models.
- Increased action potential duration at 90% (APD90) prolongation in congestive heart failure (CHF) dogs compared to controls at 0.01 mg/kg.
Medchemexpress LLC Fumarate hydratase-IN-2 sodium salt | 2070009-45-7 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 1 ML
Fumarate hydratase-IN-2 sodium salt is a cell-permeable, competitive inhibitor of fumarate hydratase (Ki = 4.5 μM) used for biochemical and cell-based research into enzyme function and metabolic responses. It is supplied in high-purity form with solution and solid formats to support varied experimental workflows.
- Cell-permeable competitive inhibitor of fumarate hydratase (Ki = 4.5 μM).
- Reported nutrient-dependent cytotoxicity in cell studies.
- High purity suitable for research applications (98.7% reported).
- Available as 10 mM solution in DMSO (1 mL) and as solid quantities for flexibility.
- Molecular formula C25H25N2NaO4 and molecular weight 440.47 g/mol.
- Includes product data sheet and certificate of analysis for batch-specific quality assurance.