Dioxolanes
Medchemexpress LLC Topiramate (Standard) | 97240-79-4 | 99.8% | 10 MM * 1 ML
Topiramate is a broad-spectrum antiepileptic agent and a GluR5 receptor antagonist. Its antiepileptic effects are attributed to enhancing GABAergic activity, inhibiting kainate/AMPA receptors, blocking voltage-sensitive sodium and calcium channels, increasing potassium conductance, and inhibiting carbonic anhydrase.
- Enhances GABAergic activity
- Inhibits kainate/AMPA receptors
- Blocks voltage-sensitive sodium and calcium channels
- Increases potassium conductance
- Inhibits carbonic anhydrase
- Use-dependent inhibition of voltage-dependent Na+ channels in neurons
- Potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx
- Antagonizes kainate/AMPA receptors for inhibitory effects on inward currents
Selleck Chemical LLC Topiramate S1438-1g
Topiramate (MCN 4853 RWJ 17021) is a mutil-targeted inhibitor including voltage-gated sodium channel and calcium channel AMPA/kainate receptor and carbonic anhydrase used to treat epilepsy
Selleck Chemical LLC Ertugliflozin S5413-25mg
Ertugliflozin (MK-8835 PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0 877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1
Selleck Chemical LLC Ertugliflozin S5413-5mg
Ertugliflozin (MK-8835 PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0 877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1
Medchemexpress LLC Topiramate (Standard) | 97240-79-4 | 50 MG
Topiramate (McN 4853) is a solid, broad-spectrum antiepileptic agent and a GluR5 receptor antagonist. Its antiepileptic effects are attributed to multiple mechanisms, including enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, and inhibition of voltage-sensitive sodium and calcium channels. It is believed to block the spread of seizures.
- Enhances GABAergic activity.
- Inhibits kainate/AMPA receptors.
- Inhibits voltage-sensitive sodium and calcium channels.
- Increases potassium conductance.
- Inhibits carbonic anhydrase.
Medchemexpress LLC Ertugliflozin L-pyroglutamic acid | 1210344-83-4 | 99.8% | 566.00 | 5 MG
Ertugliflozin L-pyroglutamic acid is a potent, selective, and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. It has potential for the treatment of type 2 diabetes mellitus.
- Potent, selective, and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2)
- Potential for the treatment of type 2 diabetes mellitus
- Demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro
- Reveals a concentration-dependent glucosuria after oral administration to rats
Medchemexpress LLC Topiramate (Standard) | 97240-79-4 | MFCD00865320 | 25 MG
Topiramate (Standard) is a hexose derivative that acts as an anticonvulsant and sodium channel blocker. It is primarily used as a laboratory chemical and for the manufacture of substances, with applications in antiepileptic treatment and migraine prevention. This compound is supplied as a solid and maintains stability under recommended storage conditions.
- Functions as an anticonvulsant and sodium channel blocker
- Used in laboratory chemicals and for substance manufacturing
- Recommended storage at 4°C, sealed, away from light and moisture
- Stable under recommended storage conditions
- Solid appearance
- For research use only
Medchemexpress LLC Topiramate (McN 4853) | 97240-79-4 | 99.8% | 500 MG
Topiramate is a broad-spectrum antiepileptic agent and a GluR5 receptor antagonist. It produces its antiepileptic effects by enhancing GABAergic activity, inhibiting kainate/AMPA receptors, inhibiting voltage-sensitive sodium and calcium channels, increasing potassium conductance, and inhibiting carbonic anhydrase. This product is for research use only.
- Broad-spectrum antiepileptic agent
- GluR5 receptor antagonist
- Enhances GABAergic activity
- Inhibits kainate/AMPA receptors
- Inhibits voltage-sensitive sodium and calcium channels
- Increases potassium conductance
- Inhibits carbonic anhydrase
Medchemexpress LLC Topiramate (Standard) | 97240-79-4 | 99.8% | 5 MG
Topiramate (Standard) is the analytical standard of Topiramate, intended for research and analytical applications. Topiramate is a broad-spectrum antiepileptic agent and a GluR5 receptor antagonist. Its antiepileptic effects are produced through the enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. It is believed to block the spread of seizures.
- Broad-spectrum antiepileptic agent
- GluR5 receptor antagonist
- Enhances GABAergic activity
- Inhibits kainate/AMPA receptors
- Inhibits voltage-sensitive sodium and calcium channels
- Increases potassium conductance
- Inhibits carbonic anhydrase
- Intended for research and analytical applications
Medchemexpress LLC Topiramate D12 | 1279037-95-4 | 99.9% | 351.44 | 100 MG
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate, functioning as a broad-spectrum antiepileptic agent and GluR5 receptor antagonist. Its antiepileptic effects are achieved by enhancing GABAergic activity, inhibiting kainate/AMPA receptors, inhibiting voltage-sensitive sodium and calcium channels, increasing potassium conductance, and inhibiting carbonic anhydrase. This compound is intended for research and analytical applications.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Enhances GABAergic activity.
- Inhibits kainate/AMPA receptors.
- Inhibits voltage-sensitive sodium and calcium channels.
- Increases potassium conductance.
- Inhibits carbonic anhydrase.
Apexbio Technology LLC Topiramate 97240-79-4 10mM (in 1mL DMSO)
Topiramate (CAS 97240-79-4) is an anticonvulsant compound widely investigated for its interactions with multiple neuronal ion channels and neurotransmitter receptors including AMPA kainate and NMDA glutamate receptors as well as GABA A receptors and voltage-gated Na channels In vitro studies demonstrate that at submicromolar concentrations (IC 0 5 M) topiramate selectively inhibits GluR5-containing kainate receptor-mediated excitatory synaptic currents in rat basolateral amygdala neurons and partially attenuates AMPA receptor-mediated responses Electrophysiological assays in cortical slices reveal that topiramate modulates persistent Na currents and shifts steady-state inactivation In animal models topiramate confers dose-dependent neuroprotection in ischemic stroke and elevates seizure thresholds supporting its utility for mechanistic studies of epilepsy and neuroprotection
TARGETMOL CHEMICALS INC SILPERISONE HCL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells decreases excitability and contractility of muscle cells reduces peripheral tone and acts as a muscle relaxant and peripheral vasodilator. Silperisone HCl is used to treat recurrent painful myoclonus due to spinal cord injury abnormal hypertonia due to cerebrovascular disease dystonia symptoms cone tension syndrome multiple sclerosis myospasm and myelitis. silperisone is a sodium channel protein type 2 alpha channel blocker. silperisone is an organosilicon similar to tolperisone an organosilicon compound with centrally acting muscle relaxant properties. purity: 99%
Apexbio Technology LLC Topiramate 97240-79-4 100mg
Topiramate (CAS 97240-79-4) is an anticonvulsant compound widely investigated for its interactions with multiple neuronal ion channels and neurotransmitter receptors including AMPA kainate and NMDA glutamate receptors as well as GABA A receptors and voltage-gated Na channels In vitro studies demonstrate that at submicromolar concentrations (IC 0 5 M) topiramate selectively inhibits GluR5-containing kainate receptor-mediated excitatory synaptic currents in rat basolateral amygdala neurons and partially attenuates AMPA receptor-mediated responses Electrophysiological assays in cortical slices reveal that topiramate modulates persistent Na currents and shifts steady-state inactivation In animal models topiramate confers dose-dependent neuroprotection in ischemic stroke and elevates seizure thresholds supporting its utility for mechanistic studies of epilepsy and neuroprotection
TARGETMOL CHEMICALS INC ERTUGLIFLOZIN 100MG
Also available in 5 mg 10 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). purity: 99%
Medchemexpress LLC Ertugliflozin | 1210344-57-2 | C22H25ClO7 | 5 MG
Ertugliflozin is a potent, selective, and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). It has an IC50 of 0.877 nM for h-SGLT2 and demonstrates over 2000-fold selectivity for SGLT2 inhibition relative to SGLT1 in vitro. This compound has potential for the treatment of type 2 diabetes mellitus.
- Potent and selective SGLT2 inhibitor
- Orally active
- Demonstrated concentration-dependent glucosuria in vivo
- Potential for type 2 diabetes mellitus treatment