Dithiolanes
Medchemexpress LLC Isophthalic-2,4,5,6 Acid-d4 | 148472-48-4 | 99.7% | 170.16 | 5 MG
Isophthalic-2,4,5,6 Acid-d4 is the deuterium labeled Isophthalic acid. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium substitution can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC α-Lipoic Acid (Thioctic acid) | 1077-28-7 | MFCD00005474 | 206.33 | 1 ML
α-Lipoic Acid (Thioctic acid) is an antioxidant and an essential cofactor of mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 LTR activation and induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. It can also be used with CPUL1 (HY-151802) to form self-assembled nanoaggregate CPUL1-LA NA, which shows improved antitumor efficacy compared to CPUL1. This product is for research use only.
- Plays an essential role in mitochondrial bioenergetics.
- Reduces lipid accumulation in the liver.
- Increases NAD+/NADH ratio in HepG2 cells.
- Increases SIRT1 activity in HepG2 cells.
- Increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells.
- Markedly reduces visceral fat mass in C57BL/6J mice.
- Inhibits appetite and causes significant weight loss in mice.
eMolecules 1077-28-7 | ALPHA-LIPOIC ACID | AstaTech | MFCD00005474 | 206.320 | C8H14O2S2 | 95.000 | OC(=O)CCCCC1CCSS1 | 100g | 696746721
ALPHA-LIPOIC ACID | AstaTech | 1077-28-7 | MFCD00005474 | 206.320 | C8H14O2S2 | 95.000 | OC(=O)CCCCC1CCSS1 | 100g | 696746721
Medchemexpress LLC Isophthalic-2,4,5,6 acid-d4 | 148472-48-4 | MFCD00209746 | 99.7% | 170.16 g/mol | C8H2D4O4 | 10 MG
Isophthalic-2,4,5,6 Acid-d4 is the deuterium-labeled analogue of isophthalic acid supplied as a solid stable-isotope standard for analytical and tracer applications. It is intended for use as an internal standard in quantitative NMR, GC-MS, and LC-MS assays and for tracer studies requiring deuterium labeling.
- Deuterium-labeled for tracer and internal standard applications.
- Suitable as an internal standard for quantitative NMR, GC-MS, and LC-MS.
- Supplied as a solid powder for convenient handling and storage.
- High chemical purity of 99.7% for reliable analytical performance.
- Stable when stored under recommended conditions to maintain integrity.
Medchemexpress LLC 1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 40846-94-4 | 98.0% | C12H17NO4S2 | 1 G
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands with a linker: one targeting an E3 ubiquitin ligase and the other binding to the protein of interest. This product is for research use only.
- Alkyl/ether-based linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Alpha-Lipoic acid-NHS | 40846-94-4 | 98.0% | C12H17NO4S2 | 100 MG
Alpha-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Alkyl/ether based PROTAC linker
- Used in synthesis of PROTACs
- Solid appearance
- White to yellow color
- Molecular weight of 303.40
- Purity of 98.0%
Medchemexpress LLC Anethole trithione | 532-11-6 | 500MG
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.5% | C8H6O5 | 25 MG
4-Hydroxyisophthalic acid activates antioxidant enzymes, such as catalase (CAT) and superoxide dismutase (SOD), scavenges free radicals, and exhibits antioxidant property. It also activates AChE and BChE, enhancing neuronal function and improving Tau-induced neurobehavioral defects. Additionally, it improves cognitive defects and ameliorates circadian rhythm disorders in fruit flies.
- Activates antioxidant enzymes (CAT and SOD)
- Scavenges free radicals
- Exhibits antioxidant properties
- Enhances neuronal function
- Improves Tau-induced neurobehavioral defects
- Ameliorates circadian rhythm disorders
- Molecular weight: 182.13
- Appearance: Solid
- Color: Off-white to pink
- Structure classification: Ketones, aldehydes, acids
- Derived from plants Apocynaceae Decalepis hamiltonii Wight & Arn.
- For research use only
Apexbio Technology LLC MRT-2359-10MG
MRT-2359 (CAS No 2803881-11-8) is a research compound in the biomedical field originating from studies of cellular signal transduction pathways It functions primarily by modulating specific protein targets involved in disease progression utilizing mechanisms such as enzyme inhibition or receptor modulation Its activity is typically observed in the nanomolar to low micromolar range making it effective in in vitro experiments Common applications include studies in various cell models animal studies for disease modeling and high-throughput drug screening platforms Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC ANETHOLE-TRITHIONE-500MG
Anethole trithione (CAS No 532-11-6) is a compound primarily studied in the field of biomedical research due to its potential therapeutic properties Originating from the derivative of anethole it is known for modulating bile secretion and may exert its effects through antioxidant pathways Research suggests that anethole trithione exhibits activity in nanomolar to low micromolar ranges Commonly employed in vitro studies often utilize hepatic and cancer cell models exploring its potential in modulating cellular oxidative stress Animal studies frequently investigate its role in liver health offering insights into potential clinical applications Moreover anethole trithione is utilized in drug screening assays to evaluate its efficacy and mechanism of action Experimental concentrations typically depend on the specific research design allowing flexibility in its application across diverse experimental setups
![Alkali Scientific DL Thioctic Acid [DL a Lipoic acid], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660394.jpg-250.jpg)
Alkali Scientific DL Thioctic Acid [DL a Lipoic acid], 1 G
DL Thioctic Acid (DL Alpha Lipoic Acid), 1G, is a potent antioxidant used in various biological and chemical applications. This formulation is a racemic mixture of both the D- and L- forms of alpha-lipoic acid, a sulfur-containing fatty acid that plays a crucial role in cellular metabolism and acts as a cofactor for several mitochondrial enzymes. In addition to its antioxidant properties, DL Alpha Lipoic Acid has shown therapeutic potential in neuroprotective and anti-inflammatory treatments. It is commonly used in laboratory research for cell protection studies and metabolic assays and is also a key ingredient in pharmaceutical formulations for supporting liver health and treating diabetic neuropathy.