Dithiolanes
Sigma Aldrich 5-Bromoisophthalic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Amino-2-phenethylisoindoline-1,3-dione
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Aminoisophthalic Acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-(1H-1,2,4-Triazol-1-yl)butanoic acid hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Isophthalic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
![Sigma Aldrich 3-(4-Chloro-3-methylphenoxy)-8-[(dipropylamino)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one](https://assets.fishersci.com/TFS-Assets/CCG/Sigma-Aldrich/product-images/5f6b3e48-37fb-41f4-b6e8-5b63609bed62.jpg-250.jpg)
Sigma Aldrich 3-(4-Chloro-3-methylphenoxy)-8-[(dipropylamino)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC 1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 40846-94-4 | 98.0% | C12H17NO4S2 | 1 G
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands with a linker: one targeting an E3 ubiquitin ligase and the other binding to the protein of interest. This product is for research use only.
- Alkyl/ether-based linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC (S)-thioctic acid | 1077-27-6 | MFCD01863481 | >=97.0% | 206.33 g/mol | C8H14O2S2 | 1 ML
(S)-Thioctic acid (S-lipoic acid) is the S-enantiomer of lipoic acid, a thiol-containing antioxidant and enzymatic cofactor used in biochemical research. It participates in redox chemistry and mitochondrial enzyme function. The product is supplied as a ready-to-use 10 mM solution in DMSO and as solids for preparative or analytical work, suitable for enzymology and antioxidant studies.
- Chiral antioxidant and mitochondrial cofactor
- Available as 10 mM solution in DMSO for immediate use
- Also available as solid for bulk or formulation
- Useful for enzymology, redox, and antioxidant assays
- High purity (≥97%) suitable for HPLC applications
- Stable when stored under recommended conditions
Medchemexpress LLC Alpha-Lipoic acid-NHS | 40846-94-4 | 98.0% | C12H17NO4S2 | 100 MG
Alpha-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Alkyl/ether based PROTAC linker
- Used in synthesis of PROTACs
- Solid appearance
- White to yellow color
- Molecular weight of 303.40
- Purity of 98.0%
Medchemexpress LLC MRT-2359 | 2803881-11-8 | C22H17F4N3O6 | 25 MG
MRT-2359 is a potent, orally active, and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. It exhibits significant anti-proliferative activity in various cancer cell lines, particularly MYC-driven cell lines like non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high N-Myc or L-Myc expression, making it suitable for cancer research.
- Potent, orally active, and selective GSPT1 depressant
- Specifically induces apoptosis dependent on protein translation
- Significant anti-proliferative activity in MYC-driven cancer cell lines
- Effective against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)
- Inhibits the growth of drug-resistant NSCLC and SCLC cells
- Reduces N-Myc protein expression and tumor size
- Active against prostate cancer
Medchemexpress LLC Alpha-lipoic acid choline ester chloride | 1808266-58-1 | 99.7% | 327.93 | C13H26ClNO2S2 | 5 MG
Alpha-lipoic acid choline ester chloride is a choline ester derivative of alpha-lipoic acid provided for laboratory research. It can reduce protein disulfides and has been studied for improving lens elasticity and other presbyopia-related effects. The compound is supplied as a solid and as prepared DMSO solutions; store sealed at 4°C and handle per standard laboratory safety procedures.
- Choline ester derivative of alpha-lipoic acid
- Reduces protein disulfides
- Enhances lens elasticity in preclinical studies
- Available as solid and 10 mM DMSO solutions
- High purity (99.7%)
- Molecular formula C13H26ClNO2S2; molecular weight 327.93
Medchemexpress LLC Alpha-lipoic acid-NHS | 40846-94-4 | 98.0% | C12H17NO4S2 | 250 MG
Alpha-lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs feature two ligands connected by a linker, one for an E3 ubiquitin ligase and another for a target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system. This compound has a molecular weight of 303.40 and is a white to yellow solid, intended for research use only.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Molecular weight of 303.40
- Appears as a white to yellow solid
- Shipping at room temperature (continental US)
- Storage at -20°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Solubility in ethanol: 2 mg/mL (6.59 mM) with ultrasonic and warming to 60°C
Apexbio Technology LLC Fasudil (HA-1077) HCl 105628-07-7 10mM (in 1mL DMSO)
Fasudil HA-1077 HCl (CAS 105628-07-7) is a small-molecule inhibitor targeting Rho-associated protein kinase (ROCK) a serine/threonine kinase It is designed to inhibit ROCK thereby regulating cellular processes such as proliferation migration and apoptosis Fasudil HA-1077 HCl exerts its biological activity primarily through ROCK inhibition In cell-based studies Fasudil inhibits proliferation and migration and promotes apoptosis in cancer cell models including bladder carcinoma (5637 UM-UC-3) and oral squamous cell carcinoma (SCC-4) its ROCK inhibitory activity shows an IC50 value of approximately 0 74 M Based on these pharmacological properties Fasudil HA-1077 HCl holds research potential in oncology and disease models involving ROCK-mediated signaling
Apexbio Technology LLC Fasudil (HA-1077) HCl 105628-07-7 500mg
Fasudil HA-1077 HCl (CAS 105628-07-7) is a small-molecule inhibitor targeting Rho-associated protein kinase (ROCK) a serine/threonine kinase It is designed to inhibit ROCK thereby regulating cellular processes such as proliferation migration and apoptosis Fasudil HA-1077 HCl exerts its biological activity primarily through ROCK inhibition In cell-based studies Fasudil inhibits proliferation and migration and promotes apoptosis in cancer cell models including bladder carcinoma (5637 UM-UC-3) and oral squamous cell carcinoma (SCC-4) its ROCK inhibitory activity shows an IC50 value of approximately 0 74 M Based on these pharmacological properties Fasudil HA-1077 HCl holds research potential in oncology and disease models involving ROCK-mediated signaling
Medchemexpress LLC 4-Hydroxyisophthalic acid | 636-46-4 | 99.51% | C8H6O5 | 100 MG
4-Hydroxyisophthalic acid is a compound known for its antioxidant properties. It functions by activating key antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD), and by scavenging free radicals. This compound also enhances neuronal function through the activation of AChE and BChE, which can lead to improvements in neurobehavioral defects induced by Tau protein and can ameliorate circadian rhythm disorders.
- Activates antioxidant enzymes (catalase CAT and superoxide dismutase SOD)
- Scavenges free radicals
- Exhibits antioxidant properties
- Activates AChE and BChE
- Enhances neuronal function
- Improves Tau-induced neurobehavioral defects
- Ameliorates circadian rhythm disorders in fruit flies