Imidazopyridines
Medchemexpress LLC Odoroside A | 12738-19-1 | 5 MG
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. It exhibits anticancer activity by inducing apoptosis and cell cycle arrest through the ROS/p53 signaling pathway, which leads to tumor cell death. This compound has a molecular weight of 518.68 and a molecular formula of C30H46O7, appearing as a white to off-white solid. It is classified under steroids and is initially sourced from plants in the Apocynaceae family.
- High purity: 99.73%
- Induces apoptosis and cell cycle arrest
- Targets the ROS/p53 signaling pathway
- Active against various cancer cell lines including A549, HepG2, and WI-38
- Soluble in DMSO (100 mg/mL)
- White to off-white solid appearance
- Classified as a steroid
Medchemexpress LLC Odoroside A | 12738-19-1 | 10 MG
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. It exhibits anti-cancer activity by inducing apoptosis and cell cycle arrest through the ROS/p53 signaling pathway, leading to tumor cell death.
- Active ingredient extracted from Nerium oleander Linn
- Exhibits anti-cancer activity
- Induces apoptosis and cell cycle arrest
- Works via the ROS/p53 signaling pathway
- Leads to tumor cell death
- High purity of 99.73%
- Molecular weight: 518.68
- Molecular formula: C₃₀H₄₆O₇
- Appearance: White to off-white solid
- Soluble in DMSO
- Targeted pathway: Apoptosis
- For research use only
Medchemexpress LLC 3-cl-pyridine-amide-acrylaldehyde-piperazine | 99.3% | 294.74 | 25 MG
This product is a synthetic intermediate of LO-4-25 (HY-176067), an androgen receptor (AR) DNA binding domain ligand. LO-4-25 robustly degrades both AR and AR-V7 in 22Rv1 cells.
- Synthetic intermediate for LO-4-25.
- Androgen receptor (AR) DNA binding domain ligand precursor.
- Facilitates robust degradation of AR and AR-V7 in 22Rv1 cells.
Medchemexpress LLC Cxcr7 antagonist-1 | 1613021-99-0 | 99.9% | 390.41 | 50 MG
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. It is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases.
- Inhibits binding of SDF-1 (CXCL12) or I-TAC (CXCL11) to the chemokine receptor CXCR7.
- Useful in preventing tumor cell proliferation and formation.
- Applied in inflammatory diseases.
- Restores CXCL11 or RSV infection-induced β2-adrenergic receptor (β2AR) downregulation in infant airway smooth muscle cells.
- Inhibits airway smooth muscle relaxation induced by RSV-infection in BALB/c mouse models.
Medchemexpress LLC 3-Cl-Pyridine-amide-acrylaldehyde-piperazine | 99.3% | 294.74 | 50 MG
3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate of LO-4-25. LO-4-25 is an androgen receptor (AR) DNA binding domain ligand linked via a linker to the truncated fumaramide handle. This product shows robust degradation of both AR and AR-V7 in 22Rv1 cells.
- Synthetic intermediate.
- Degrades androgen receptor (AR) and AR-V7 in 22Rv1 cells.
- For research use only.
- Relevant to cancer research.
Medchemexpress LLC CXCR7 antagonist-1 | 1613021-99-0 | 99.85% | 390.41 | 100 MG
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (CXCL12) or I-TAC (CXCL11) to the chemokine receptor CXCR7. It is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases.
- Inhibits SDF-1 and I-TAC chemokine binding
- Useful in preventing tumor cell proliferation
- Useful in preventing tumor formation
- Useful in preventing inflammatory diseases
- Useful in preventing many other diseases
Sigma Aldrich Fine Chemicals Biosciences 2-AAPA hydrate 95 HPLC5MG
2-Acetylamino-3-[4-(2-acetylamino-2-carboxy-ethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid (2-AAPA) can block reductase systems thereby modulating peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells.
Medchemexpress LLC 3-Cl-Pyridine-amide-acrylaldehyde-piperazine | 99.30% | 294.74 | 100 MG
3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate of LO-4-25. LO-4-25 is an androgen receptor (AR) DNA binding domain ligand linked via a linker to the truncated fumaramide handle. LO-4-25 shows robust degradation of both AR and AR-V7 in 22Rv1 cells.
- Synthetic intermediate of LO-4-25
- Androgen receptor (AR) DNA binding domain ligand
- Shows robust degradation of both AR and AR-V7 in 22Rv1 cells
- For research use only
Medchemexpress LLC BI-1622 | 2681392-19-6 | 99.0% | 508.53 | 5 MG
BI-1622 is an orally active, potent, and highly selective HER2 (ERBB2) inhibitor with an IC50 of 7 nM. It demonstrates over 25-fold selectivity for HER2 compared to EGFR. BI-1622 exhibits high antitumor efficacy in vivo in xenograft mouse tumor models using engineered H2170 and PC9 cells, and it possesses a favorable agent metabolism and pharmacokinetics profile.
- Inhibits proliferation of HER2-dependent cell lines.
- Induces a dose-dependent decrease in pHER2 and pERK levels.
- Displays good permeability and no PgP-mediated efflux liability.
- Shows good in vitro clearance in mouse liver microsomes and mouse hepatocytes.
- Potently inhibited the proliferation of cancer cell lines dependent on amplified HER2 or an NRG-1 fusion.
- Shows moderate clearance, a moderate volume of distribution, and good to moderate bioavailability up to 68%.
- Inhibits tumor growth and oncogenic signaling.
Medchemexpress LLC DB2115 tertahydrochloride | 1366126-19-3 | 99.1% | 704.48 | C32H34Cl4N8O2 | 5MG
DB2115 tertahydrochloride is a small-molecule inhibitor of the transcription factor PU.1 supplied as a tertahydrochloride salt for research use. It suppresses PU.1 binding to DNA (IC50: 2.3 nM), exhibits antiproliferative and pro-apoptotic activity in tumor cell models, and is provided as a solid powder suitable for biochemical and cellular studies.
- Highly potent PU.1 inhibition (IC50: 2.3 nM).
- Demonstrates antiproliferative and pro-apoptotic effects in tumor cells.
- High purity for research applications.
- Available in multiple small-scale pack sizes for experimental flexibility.
- Stable when stored sealed at recommended temperatures.
Medchemexpress LLC HY-13307 5mg Medchemexpress, JK184 CAS:315703-52-7 Purity:>98%
Medchemexpress, HY-13307 5mg JK184 CAS:315703-52-7 JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Cxcr7 antagonist-1 hydrochloride | 2990472-61-0 | 99.4% | 426.87 | 50 MG
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of SDF-1 chemokine (CXCL12) or I-TAC (CXCL11) to the chemokine receptor CXCR7.
- Useful in preventing tumor cell proliferation and formation
- Helps prevent inflammatory diseases
- Restores CXCL11 or RSV infection-induced β2-adrenergic receptor (β2AR) downregulation
- Inhibits RSV-infection induced airway smooth muscle relaxation in BALB/c mouse models
Apexbio Technology LLC 2-ET 5-7 DIME IMIDAZO-500mg
2-Ethyl-5 7-dimethyl-3H-imidazo[4 5-b]pyridine (CAS No 133240-06-9) is a synthetic compound studied in the field of biomedical research for its potential pharmacological properties This compound is noted for its activity in targeting specific biochemical pathways though the exact mechanism of action remains under investigation In vitro it demonstrates activity in the nanomolar to low micromolar range indicating potential efficacy in diverse biochemical assays It is often used in cell model studies animal research and drug screening applications Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC 2-ET 5-7 DIME IMIDAZO-100mg
2-Ethyl-5 7-dimethyl-3H-imidazo[4 5-b]pyridine (CAS No 133240-06-9) is a synthetic compound studied in the field of biomedical research for its potential pharmacological properties This compound is noted for its activity in targeting specific biochemical pathways though the exact mechanism of action remains under investigation In vitro it demonstrates activity in the nanomolar to low micromolar range indicating potential efficacy in diverse biochemical assays It is often used in cell model studies animal research and drug screening applications Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC 2-ET 5-7 DIME IMIDAZO-250mg
2-Ethyl-5 7-dimethyl-3H-imidazo[4 5-b]pyridine (CAS No 133240-06-9) is a synthetic compound studied in the field of biomedical research for its potential pharmacological properties This compound is noted for its activity in targeting specific biochemical pathways though the exact mechanism of action remains under investigation In vitro it demonstrates activity in the nanomolar to low micromolar range indicating potential efficacy in diverse biochemical assays It is often used in cell model studies animal research and drug screening applications Experimental concentrations typically depend on the specific research design
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