Lactams
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
Medchemexpress LLC Thalidomide-piperazine-PEG1-COOH | 2731007-11-5 | 99.2% | 458.46 | 25 MG
Thalidomide-Piperazine-PEG1-COOH is a synthetic E3 ligase ligand-linker coupler containing a Thalidomide-based ligand and one linker. It acts as an E3 ligase ligand-linker conjugate.
- E3 ligase ligand-linker coupler
- Contains a Thalidomide-based ligand and one linker
Medchemexpress LLC Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | 99.9% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Thalidomide-NH-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) construction and related chemical biology research. Provided as a light yellow solid with high purity and defined storage stability, it is intended for laboratory research use only.
- High purity (99.85%) suitable for research applications.
- Hydrochloride salt form to aid handling and solubility considerations.
- Available in small research pack sizes, including 10 mg, for synthesis workflows.
- Designed to act as a CRBN-binding E3 ligase ligand in PROTAC constructs.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (trifluoroacetate) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 50 MG
Thalidomide-O-amido-C4-NH2 (trifluoroacetate) is a thalidomide-derived cereblon ligand supplied as the TFA salt for use as an E3 ligase ligand/linker building block in PROTAC and chemical biology research.
- Provided as the trifluoroacetate salt.
- High purity (99.9%, LCMS).
- Molecular weight 516.42 g/mol.
- CAS number 1799711-25-3.
- Appearance: solid, white to off-white.
- Packaged as a 50 MG quantity.
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (TFA) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 1 G
Thalidomide-O-amido-C4-NH2 (TFA) is a thalidomide-derived cereblon ligand supplied as the trifluoroacetate salt and intended as a building block for E3 ligase ligand-linker conjugates and PROTAC research. The compound is provided as a solid research reagent with characterized purity, formula, and solubility data for in vitro and in vivo formulation.
- Intended for research use only.
- High purity 99.92%.
- Molecular weight 516.42 g/mol.
- Molecular formula C21H23F3N4O8.
- Soluble in DMSO (~42.86 mg/mL); multiple in vivo formulation protocols reported.
- Store dry at 4°C; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Thalidomide-o-amido-C3-COOH | 2308035-51-8 | 98.4% | 417.37 | C19H19N3O8 | 2 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short C3 linker terminating in a carboxylic acid. It is intended for use as a CRBN-recruiting building block in PROTAC synthesis and related targeted protein degradation research.
- used as a cereblon (CRBN) recruiting building block in PROTAC synthesis
- terminates in a carboxylic acid for conjugation to target ligands
- reported purity 98.43% by LCMS
- molecular weight 417.37; formula C19H19N3O8
- storage: 4°C under nitrogen; in solution store at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-5-Br | 26166-92-7 | 98.4% | 337.13 g/mol | C13H9BrN2O4 | 50 MG
Thalidomide-5-Br is a brominated thalidomide analogue supplied for biochemical research. It has a reported molecular weight of 337.13 g/mol and is supplied as an off-white to gray solid with reported purity around 98%.
- Used in research of inflammation, tumor biology, and neurology.
- Supplied as a solid suitable for formulation or dissolution in solvent for experimental use.
- Reported high purity for analytical and preclinical studies.
- Stable at room temperature for extended storage; in-solution storage requires low temperatures.
![Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403850-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound that appears as a light yellow to yellow oil. This product has been thoroughly tested and complies with the given specifications, ensuring its quality and suitability for research purposes.
- Molecular formula: C26H36N4O9
- Molecular weight: 548.59
- Purity (LCMS): 97.20%
- Storage for pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 1 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. Thalidomide targets cereblon (CRBN), a protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The product appears as an off-white to gray solid.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to the ligand for IRAK4 protein to form PROTAC IRAK4 degrader-1
- Targets cereblon (CRBN), part of the CUL4-RBX1-DDB1 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
Medchemexpress LLC N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g·mol⁻¹ | C21H23F3N4O8 | 2 G
Thalidomide-O-amido-C4-NH2 TFA is a thalidomide-derived cereblon ligand-linker conjugate provided as the trifluoroacetate (TFA) salt for use in PROTAC design and other chemical biology applications. It is supplied as a white to off-white solid with high analytical purity and a molecular weight of 516.42 g·mol⁻¹.
- Thalidomide-derived cereblon ligand-linker conjugate.
- Provided as the trifluoroacetate (TFA) salt.
- High purity by LCMS (reported 99.92%).
- White to off-white solid appearance.
- Molecular formula C21H23F3N4O8; molecular weight 516.42 g·mol⁻¹.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 g/mol | C21H28ClN3O8 | 5 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide moiety with a four-unit PEG linker. It is intended as a research reagent for PROTAC design and targeted protein degradation studies and is supplied as a light yellow to yellow oil with reported high purity.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC synthesis.
- Contains a cereblon-binding thalidomide moiety with a PEG4 linker for linker flexibility.
- High reported purity suitable for research applications (95.2%).
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Light yellow to yellow oil; easy to handle in synthetic workflows.
- Store sealed away from moisture; recommended storage at -20°C (in solvent: -80°C for long term).
Medchemexpress LLC Thalidomide-5 6-F 1g
Thalidomide-5 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein Thalidomide-5 6-F can be connected to the ligand for protein by a linker to form PROTACs[1]
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | 486.56 g·mol⁻¹ | C26H34N2O7 | 5 MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand for targeted protein degradation research. It is designed to be connected to a protein-targeting ligand via a linker to form PROTAC molecules and is provided as a research-grade chemical with manufacturer-reported purity (~95.1%).
- Acts as a cereblon ligand to recruit CRBN.
- Designed for conjugation via a linker to form PROTACs.
- Supplied at research-grade purity (~95.1%).
- Molecular formula C26H34N2O7; molecular weight 486.56 g·mol⁻¹.
- Available in milligram-scale quantities suitable for synthesis and screening.