Lactams
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 100 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide supplied for laboratory research. It promotes protein ubiquitinylation and serves as a cereblon-binding ligand; the fluorine substitutions allow further chemical derivatization. Intended for scientific research use only.
- Fluorinated thalidomide analogue enabling further derivatization.
- Promotes ubiquitinylation and binds cereblon for E3 ligase recruitment.
- High purity (98.0%) suitable for research applications.
- Available in multiple package sizes from 25 mg to 10 g.
- White to off-white solid, suitable for storage and handling.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.9% | 522.08 | C27H40ClN3O5 | 10 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a carbon-14 radiolabeled thalidomide derivative used as a cereblon (CRBN) ligand in research applications, including PROTAC assembly. The product is supplied as the hydrochloride salt with high purity and characterized molecular properties for use in biochemical and pharmacokinetic studies.
![eMolecules 2227205-60-7 | tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate | Pharmablock212.293 | C11H20N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CNC1C2 | 25mg | 588505928](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502458980.PNG-250.jpg)
eMolecules 2227205-60-7 | tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate | Pharmablock212.293 | C11H20N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CNC1C2 | 25mg | 588505928
tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate | Pharmablock | 2227205-60-7212.293 | C11H20N2O2 | 97.000 | CC(C)(C)OC(=O)NC1CC2CNC1C2 | 25mg | 588505928
Apexbio Technology LLC Brucine 10mM (in 1mL DMSO)
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 97.0% | 290.25 g/mol | C14H11FN2O4 | 5 G
A fluorinated thalidomide analogue that functions as an E3 ligase (Cereblon) activator and a synthetic building block for targeted protein degradation research. Suitable for recruiting CRBN in PROTAC design and for further chemical derivatization via nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue
- Acts as an E3 ligase (Cereblon) activator
- Useful as a PROTAC ligand building block
- Compatible with SNAr derivatization
- Typical purity approximately 97.0%
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | 2636798-38-2 | >95.0% | 437.92 g/mol | C21H28ClN3O5 | 10 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research applications. It is used as a recruiting moiety in PROTACs and other E3 ligase-targeting conjugates to facilitate targeted protein degradation and chemical biology studies. Supplied as a white to off-white solid in small laboratory pack sizes, it supports synthetic conjugation through an alkyl linker.
- Serves as a cereblon-recruiting ligand for targeted protein degradation
- Supplied as a hydrochloride salt for improved stability and handling
- Solid form suitable for storage and synthetic manipulation
- Provides an alkyl linker attachment point for PROTAC assembly
- Compatible with standard organic synthesis and conjugation workflows
- Intended for research use in chemical biology and drug discovery
Abcam (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor, 25MG
MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC CD3 epsilon 1-27 pep 20ug | 20ug
CD3 epsilon is an important component of the TCR-CD3 complex on T lymphocytes and promotes TCR-mediated signaling When APC activates the TCR CD3 epsilon together with CD3D CD3G and CD3Z transmits signals across the cell membrane through ITAMs CD3 epsilon 1-27 peptide Protein Human (Biotinylated HEK293 hFc-Avi) is the recombinant human-derived CD3 epsilon 1-27 peptide protein expressed by HEK293 with C-Avi C-hFc labeled tag
Medchemexpress LLC CD3 epsilon Canine 50ug | 50ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC Fc epsilon RIA/FCER1 50ug
Recombinant human Fc epsilon RI alpha (extracellular domain) supplied as 50 μg lyophilized material with an N-terminal His-SUMO tag, intended for binding and functional studies involving human IgE.
- Prepared as lyophilized powder for long-term storage and transport.
- Includes N-terminal His-SUMO tag to facilitate affinity purification.
- Expression system: E. coli for efficient production.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Approximate molecular weight ~37 kDa for molecular characterization.
- Demonstrated IgE binding in ELISA with reported ED50 of 5.864 μg/mL.
Cambridge Isotope Laboratories N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
Medchemexpress LLC CD3 epsilon Rhesus 50ug | 50ug
CD3 epsilon Protein a vital component of the TCR-CD3 complex on T-lymphocytes is pivotal for adaptive immune responses CD3E is crucial for proper T-cell development and contributes to TCR-CD3 complex internalization and down-regulation[1] CD3 epsilon Protein Rhesus Macaque (HEK293 His) is the recombinant Rhesus Macaque-derived CD3 epsilon protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC CD3 epsilon protein (rat, HEK293-expressed, Fc tag) | ≥95.0% | 100 UG
Recombinant rat CD3 epsilon protein expressed in HEK293 cells with a C-terminal Fc tag, purified to ≥95% and supplied for use in immunoassays, binding studies, and antibody characterization.
- Recombinant rat CD3 epsilon (Y24-D103).
- Expressed in HEK293 cells for mammalian post-translational modifications.
- C-terminal Fc tag for improved stability and detection.
- Purity ≥95.0% as determined by supplier analysis.
- Supplied in a 100 μg format suitable for assay development.
- Common applications include TCR binding assays and antibody validation.