Lactams
![Medchemexpress LLC 5-[(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-isoindole-1,3-dione | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000284650.png-250.jpg)
Medchemexpress LLC 5-[(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-isoindole-1,3-dione | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 50 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate that contains a terminal alkyne for bioorthogonal conjugation. It is provided as a small-quantity research reagent intended for PROTAC development and target protein conjugation. Reported properties include a molecular formula of C16H13N3O4, a molecular weight of 311.29 g/mol, and a reported purity of 98.0%.
- Contains an E3 ligase ligand with a terminal alkyne for conjugation.
- Designed for PROTAC development and target protein degradation studies.
- Reported purity 98.0% suitable for research applications.
- Provided as a small-quantity reagent (50 mg) for synthetic chemistry workflows.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- Store and handle according to supplier safety data sheet recommendations.
![eMolecules Medchem Express / Thalidomide-Propargyne-PEG2-COOH / 50mg / 626717252 / HY-138777 / / 2797619-65-7 / [null] / 428.397 / C21H20N2O8](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480460.JPG-250.jpg)
eMolecules Medchem Express / Thalidomide-Propargyne-PEG2-COOH / 50mg / 626717252 / HY-138777 / / 2797619-65-7 / [null] / 428.397 / C21H20N2O8
Medchem Express / Thalidomide-Propargyne-PEG2-COOH / 50mg / 626717252 / HY-138777 / / 2797619-65-7 / [null] / 428.397 / C21H20N2O8
Cayman Chemical -ThalIdomIde 100mg
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Thalidomide-5 6-F 1g
Thalidomide-5 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein Thalidomide-5 6-F can be connected to the ligand for protein by a linker to form PROTACs[1]
Medchemexpress LLC Thalidomide O-amido C3-COOH | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 50 MG
Thalidomide O-amido C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a short linker terminating in a carboxylic acid. It is provided as a research-grade chemical for use in PROTAC design and related chemical biology applications.
- Contains thalidomide-based cereblon ligand
- Three-carbon (C3) linker with terminal carboxylic acid
- Molecular formula C19H19N3O8; molecular weight 417.37 g/mol
- Purity 98.4% (research grade)
- Supplied as a white solid suitable for chemical synthesis
- Intended for research use only, not for human or clinical use
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 (TFA) | 2097509-49-2 | 514.49 g/mol | C23H29F3N4O6 | 10 MG
Thalidomide-5-NH2-C8-NH2 (TFA) is a thalidomide-derived intermediate provided as the trifluoroacetic acid salt for research use and compound synthesis. It is intended for laboratory applications only and should be handled using appropriate safety procedures; store sealed at -20°C away from moisture and light. In solvent, recommended storage is -80°C for up to 6 months or -20°C for up to 1 month.
- Salt form: trifluoroacetic acid (TFA) salt.
- Suitable for compound synthesis and as a building block.
- Molecular formula: C23H29F3N4O6.
- Molecular weight: 514.49 g/mol.
- Storage: sealed at -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or clinical use.
