Lactams
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9 % | 276.22 | 50 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands by a linker to form PROTAC degraders. In vitro, Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex. Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands to form PROTAC degraders
- Targets cereblon (CRBN), a protein involved in the cullin-4 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
- High purity for reliable research
- Solid appearance, off-white to gray color
- Stable under recommended storage conditions
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 10 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Cereblon-based ligand derived from Thalidomide. It functions by recruiting the CRBN protein. This compound can be linked to an IRAK4 protein ligand using a linker to create PROTAC IRAK4 degrader-1 (HY-129966).
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands via a linker to form PROTACs
Medchemexpress LLC Thalidomide-O-amido-C8-NHBoc | 1950635-34-3 | 98.4% | 558.62 | 5 MG
Thalidomide-O-amido-C8-NHBoc contains a Thalidomide group, an amide, an alkylC8 chain, and a carbamate protecting group.
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
Abcam (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor, 100MG
MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.
![eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136107.JPG-250.jpg)
eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g
Pharmablock | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 1g | 551143363 | PBN20122091-1 | 73804-69-0 | MFCD08457561 | 163.600 | C6H10ClNO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 100 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker commonly used in PROTAC technology. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed to exploit the ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 408.88
- Chemical formula: C19H25ClN4O4
- Appearance: Light yellow to yellow solid
- Recommended storage: -20°C in sealed container, away from moisture and light
- Long-term solvent storage: 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 1 G
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not intended for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins