Lactams
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (hydrochloride) | 2245697-87-2 | >99.9% | 100 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Incorporates thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- For research use only.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 100 MG
Thalidomide-iodo is an iodinated derivative of thalidomide supplied as a research reagent. It acts as an E3 ligase activator and is suitable as a synthetic building block for further derivatization via substitution of the iodine. Typical specifications include CAS 2509137-01-1, molecular formula C13H9IN2O4, molecular weight 384.13, and reported purity of 98.0%.
- Iodinated E3 ligase activator for probe and degrader research.
- Synthetic building block amenable to substitution of iodine.
- High purity suitable for analytical and synthetic workflows.
- Available in multiple pack sizes for small-scale research.
- Intended for laboratory research use only.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 250 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 250 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be linked to a ligand for protein via a linker to create PROTACs. This product is a white to off-white solid, stable under recommended storage conditions, and intended for research use only.
- Cereblon ligand
- Utilized in CRBN protein recruitment
- Can be linked to a ligand for protein via a linker to create PROTACs
- Solid appearance
- White to off-white color
- Stable under recommended storage conditions
- Research use only
eMolecules 2245697-88-3 | Medchem Express | Thalidomide-4-O-C6-NH2 (hydrochloride) | 5mg | 599150703 | HY-135250B | 409.87 | C19H24ClN3O5
Medchem Express | Canthaxanthin | 5mg | 446274074 | HY-B1960 | 514-78-3 | MFCD00016364 | 564.854 | C40H52O2
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Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 100 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to specifically degrade target proteins. It is for research use only.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked via a linker to form PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Specifically degrades target proteins
- For research use only
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | 945.09 g/mol | C44H64N8O13S | 5 MG
Biotin-Thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied for research use in target engagement studies and PROTAC synthesis. It is provided as a high-purity chemical probe for biochemical assays, affinity capture, and conjugation workflows; not for human therapeutic use.
- High purity (≈99.7%) suitable for research applications
- Cereblon-binding probe useful for PROTAC development
- Biotin tag enables affinity capture and pull-down assays
- Compatible with conjugation and synthetic workflows
- Intended for research use only
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 | C15H12N2O7 | 5 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate in PROTAC and conjugate synthesis. The compound is fully characterized (CAS 2467425-53-0, C15H12N2O7, MW 332.26) and is provided in small milligram quantities for research use with supporting analytical documentation.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Serves as an intermediate for PROTAC and ligand-linker conjugation.
- Characterized by CAS 2467425-53-0 and formula C15H12N2O7.
- Supplied with datasheet, certificate of analysis, SDS, and spectral data.
- Typical purity approximately 95.0% by HPLC.
- Available in milligram pack sizes suitable for medicinal chemistry research.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | >98.0% | 384.13 g/mol | C13H9IN2O4 | 1 G
Thalidomide-iodo is an iodinated thalidomide derivative that acts as an E3 ligase activator and ligand for cereblon, used in targeted protein degradation and PROTAC research. The iodine substituent enables further derivatization through cross-coupling or substitution, supporting synthesis of linker conjugates and chemical probes. Supplied as a high-purity research chemical.