Lactams
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.
- Purity: 99.83%
- Molecular weight: 276.22
- Formula: C13H9FN2O4
- CAS No.: 835616-60-9
- Appearance: Solid
- Color: Off-white to gray
- Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (hydrochloride) | 2245697-87-2 | >99.9% | 100 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Incorporates thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- For research use only.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 100 MG
Thalidomide-iodo is an iodinated derivative of thalidomide supplied as a research reagent. It acts as an E3 ligase activator and is suitable as a synthetic building block for further derivatization via substitution of the iodine. Typical specifications include CAS 2509137-01-1, molecular formula C13H9IN2O4, molecular weight 384.13, and reported purity of 98.0%.
- Iodinated E3 ligase activator for probe and degrader research.
- Synthetic building block amenable to substitution of iodine.
- High purity suitable for analytical and synthetic workflows.
- Available in multiple pack sizes for small-scale research.
- Intended for laboratory research use only.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 250 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 250 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be linked to a ligand for protein via a linker to create PROTACs. This product is a white to off-white solid, stable under recommended storage conditions, and intended for research use only.
- Cereblon ligand
- Utilized in CRBN protein recruitment
- Can be linked to a ligand for protein via a linker to create PROTACs
- Solid appearance
- White to off-white color
- Stable under recommended storage conditions
- Research use only
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | 99.4% | 355.12 g·mol⁻¹ | C13H8BrFN2O4 | 50 MG
Thalidomide-4-F,5-Br is a thalidomide analogue used as a cereblon (CRBN) E3 ligase ligand in biochemical research. It is provided as a purified powder for use in degradation studies, PROTAC design, and related cell biology and biochemical assays.
- Acts as a cereblon E3 ligase ligand for targeted protein ubiquitination and degradation.
- Suitable for PROTAC synthesis and biochemical assay development.
- Supplied as a powder form for convenient handling and storage.
- High purity (~99%) suitable for research applications.
- Molecular weight approximately 355.12 g·mol⁻¹.
- Available in multiple small package sizes for laboratory use.
Medchemexpress LLC 1H-isoindole-4-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo | 1547163-38-1 | MFCD32063448 | 98.0% | 302.24 g·mol-1 | C14H10N2O6 | 500 MG
Thalidomide acid is a thalidomide-derived cereblon (CRBN) ligand bearing a carboxylic acid functional group, supplied as a solid research reagent. It is intended for use as an E3 ligase recruiting moiety in PROTAC design and related chemical biology and synthetic applications.
- Ligand for E3 ligase (CRBN) used in targeted protein degradation research.
- Carboxylic acid handle enables amide coupling and linker attachment.
- High purity (98.0%) suitable for analytical and synthetic work.
- Solid powder form for convenient handling and formulation.
- Molecular weight 302.24 g·mol-1; formula C14H10N2O6.
- Identified by CAS number 1547163-38-1 for unambiguous chemical lookup.
Medchemexpress LLC Thalidomide-5-peg4-nh2 | 2743434-16-2 | 95.21% | 449.45 | 100 MG
This compound is an E3 ligase ligand-linker conjugate that uses a Thalidomide-based cereblon ligand and a PROTAC linker. It is intended for research use only, with a recommendation to use its more stable hydrochloride salt form due to the free compound's instability.
- Designed for PROTAC technology.
- Incorporates a cereblon ligand.
- Contains a versatile linker.
- Suitable for research applications.
- Available in a more stable salt form.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | MFCD30188075 | 99.9% | 276.22 g/mol | C13H9FN2O4 | 100 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand. It is provided as a high-purity solid and is intended for use as a chemical building block in targeted protein degradation research and for further derivatization via nucleophilic aromatic substitution (SNAr).
- Functions as an E3 ligase (cereblon) ligand.
- Useful as a building block for PROTAC and targeted protein degradation design.
- Fluorinated position enables SNAr-based further derivatization.
- Supplied as a high-purity small-molecule solid suitable for synthetic chemistry.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 25 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. This compound is suitable for designing PROTAC CDK2/9 Degrader-1.
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker
- Targets cereblon
- Has a molecular weight of 416.38
- Has a molecular formula of C19H20N4O7
- Appears as a solid with a light yellow to yellow color
- Purity of 98.45%
- Soluble in DMSO at 100 mg/mL (requires ultrasonic)
- Powder storage: -20°C for 3 years
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide-5-O-C11-NH2 hydrochloride | >98.0% | 480.00 | C24H34ClN3O5 | 10 MG
Thalidomide-5-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase in targeted protein degradation constructs. Supplied as a white to off-white solid, it is intended for research use in PROTAC synthesis and ligand-linker conjugation. Handle under light protection and low-temperature storage to maintain stability.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- High purity (>98.0% HPLC) suitable for synthetic applications.
- White to off-white solid, convenient for handling and weighing.
- Stable under low-temperature, light-protected storage when handled under nitrogen.
- Available in small research quantities for conjugation and PROTAC development.
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research