Lactams
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 500 MG
Thalidomide 4-chloro is a chlorinated derivative of thalidomide that acts as an E3 ligase activator for biochemical and cell-based research. It is commonly used as a research reagent and as a synthetic building block for further derivatization at the 4-chloro position, and is offered in lab-scale pack sizes with supporting product documentation.
- Acts as an E3 ligase activator for protein degradation studies.
- Serves as a synthetic intermediate for derivatization at the 4-chloro position.
- Applicable in biochemical and cell-based assays.
- Supplied in multiple lab-scale pack sizes suitable for research.
- Molecular identity confirmed: CAS 244057-36-1, formula C13H9ClN2O4, MW 292.68 g·mol⁻¹.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
Medchemexpress LLC Thalidomide-PEG3-COOH | 2682112-08-7 | 96.95% | 434.40 | 25 MG
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
- Targets Cereblon
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | 502.52 | 25 MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used as a linker in PROTAC technology
- Related to PROTACs, an emerging therapeutic modality in precision medicine
- Related to cereblon-based small-molecule compounds for controlling neural stem cell proliferation in regenerative medicine
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | MFCD32643096 | 99.3% | 388.37 | C19H20N2O7 | 10 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a tert-butyl protected thalidomide derivative used as a cereblon (CRBN) binding ligand and as a synthetic intermediate in the preparation of PROTAC molecules. It is supplied for research use only and is not intended for human use.
- Tert-butyl protected thalidomide derivative suitable for deprotection under acidic conditions.
- Functions as a cereblon (CRBN) binding ligand for use in PROTAC design.
- High reported purity (~99.3%) for reliable research applications.
- Available in small research pack sizes (mg scale) for synthetic workflows.
- Stable at room temperature for extended storage; follow solvent storage recommendations for longer-term stability.
Medchemexpress LLC Thalidomide-5-NH2-CH2-COOH | 2412056-27-8 | 95.0% | C15H13N3O6 | 500 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (Trk) and a ligand of E3 ligase. It has potential for researching various diseases, as extracted from patent WO2021170109A1.
- Potent and selective Trk inhibitor
- Ligand of E3 ligase
- Researches various diseases including cancer, inflammation, and neurodegenerative conditions
- Solid appearance
- Color can range from light yellow to green yellow
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 25 MG
Thalidomide-5-NH-C-alkyne is a thalidomide-derived E3 ligase ligand-linker conjugate bearing a terminal alkyne for click chemistry. It is supplied as a high-purity synthetic building block intended for conjugation in PROTAC synthesis and targeted protein degradation research.
- Contains an E3 ligase ligand with a terminal alkyne for click chemistry.
- Ready for conjugation to target molecules in PROTAC synthesis.
- High purity: 98.0%.
- Provided as 25 MG powder for small-scale research use.
- Molecular weight 311.29 g/mol; formula C16H13N3O4.
- Suitable for medicinal chemistry and chemical biology applications.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | MFCD32183715 | 98.0% | 323.73 g/mol | C14H14ClN3O4 | 10 MG
Thalidomide-CH2NH2 hydrochloride is a thalidomide analogue supplied as the hydrochloride salt for research use. It features a primary aminomethyl substituent that enables further functionalization and utility as a ligand-like scaffold in biochemical studies. The compound is provided as a high-purity solid suitable for synthetic chemistry and assay development.
- Contains a primary aminomethyl group for synthetic functionalization.
- Supplied as the hydrochloride salt for improved stability and handling.
- High purity suitable for research and assay development.
- Serves as a ligand scaffold for E3 ligase-related studies.
- Available in small-scale quantities for discovery workflows.
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.
- Thalidomide-based cereblon (CRBN) ligand.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 | 2484739-21-9 | 98.6% | 922.03 | 25 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, as extracted from patent WO2020173440. This compound is intended for research use only.
- Protac-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 10mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research