Lactams
TARGETMOL CHEMICALS INC Thalidomide-O-amido-C4-N3 10MG
Also available in 1 mL, 2 mg, 5 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes.Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker. Purity 97.01%
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g·mol⁻1 | C19H21BN2O6 | 25 MG
Thalidomide-pinacolborane is a thalidomide-derived boronic pinacol ester used as a cereblon (CRBN) ligand for E3 ligase recruitment in PROTAC design and for synthetic transformations such as Suzuki cross-coupling. It is supplied as a solid research reagent intended for use in ligand design, chemical synthesis, and targeted protein degradation studies.
- Contains boronic pinacol ester (Bpin) functionality for Suzuki coupling.
- Functions as a cereblon E3 ligase ligand suitable for PROTAC applications.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g·mol⁻1.
- CAS number 2229725-98-6.
- Purity 97.0% as listed by the supplier.
- Provided as a 25 MG research pack.
Cambridge Isotope Laboratories N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
N-METHYLCAPROLACTAM (N-METHYL-D3, 98%), 5 G
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC Thalidomide-1-Me-5-NH2 | 1468761-60-5 | >98.0% | 287.27 g/mol | C14H13N3O4 | 25 MG
Thalidomide-1-Me-5-NH2 is an aminated analogue of thalidomide supplied as a research reagent. It acts as an E3 ligase ligand building block and can be derivatized at its amine for use in PROTAC design; it is not for medical, clinical diagnostic, or food use.
- Aminated thalidomide analogue suitable as an E3 ligase ligand.
- Can be derivatized at the amine for PROTAC and degrader design.
- High purity (>98.0%) appropriate for chemical biology research.
- Molecular formula C14H13N3O4, molecular weight 287.27 g/mol.
- Available in small quantities suitable for synthesis, for example 25 MG sizes.
- Supplied for research use only; not for medical or diagnostic use.
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 50 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide that serves as a cereblon (CRBN) ligand for E3 ligase recruitment and targeted protein degradation research. It promotes ubiquitinylation of proteins and is suitable for derivatization at its fluorine positions, making it a useful building block in PROTAC and molecular glue chemistries.
- Promotes ubiquitinylation of proteins.
- Useful as a cereblon ligand for E3 ligase recruitment and PROTAC synthesis.
- Fluorine positions amenable to further derivatization.
- High purity (>98.0%).
- Chemical formula C13H8F2N2O4; molecular weight 294.21 g·mol⁻¹.
- Appearance: white to off-white solid; available in multiple sizes.