Lactams
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 250 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- For research use only
- Inhibitor
Medchemexpress LLC Thalidomide-5-O-C5-NH2 hydrochloride | 2761385-94-6 | 395.84 | C18H22ClN3O5 | 10 MG
Thalidomide-5-O-C5-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as the hydrochloride salt for use in chemical biology research. It is designed for incorporation into ligand-linker conjugates and PROTAC constructs to recruit CRBN and enable targeted protein degradation. The material is supplied as a research-grade powder with recommended cold, light-protected storage conditions.
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione | 40313-92-6 | MFCD30290642 | 99.9% | C14H12N2O4 | 10MG
Thalidomide-5-methyl is a thalidomide-derived ligand that recruits the cereblon (CRBN) E3 ubiquitin ligase and is used as a recruiting moiety in proteolysis-targeting chimera (PROTAC) synthesis and CRBN-focused chemical biology research.
- Binds cereblon (CRBN) E3 ubiquitin ligase.
- Suitable as a recruiting moiety in PROTAC synthesis.
- High purity (99.9%).
- Molecular formula C14H12N2O4, molecular weight 272.26.
- Provided as a small-molecule solid, common pack size 10 mg.
- Compatible with linker conjugation for medicinal chemistry applications.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 4-[(6-azidohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- | 2411389-65-4 | 99.10% | 399.40 | 25 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It functions as a click chemistry reagent, containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits intracellular ubiquitin-proteasome system for selective target protein degradation
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 1 G
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates the Thalidomide based cereblon ligand.
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | 99.5% | 258.23 | 100 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It possesses immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- Immunomodulatory effects
- Anti-inflammatory effects
- Antiangiogenic effects
- Pro-apoptotic effects
- Induces teratogenic effects by binding to cereblon (CRBN)
- For research use only
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 25 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can act as an immunomodulator for the treatment of cancer. It is for research use only and not sold to patients.
- PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein.
- PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thalidomide-NH-PEG3-propionic acid | 2138440-82-9 | 99.72% | 477.46 | 25 MG
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate used in PROTAC technology. It incorporates a thalidomide-based cereblon ligand and a 3-unit PEG linker.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Stable under recommended storage conditions.
- Recommended storage temperature: 4°C, protect from light.
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
Medchemexpress LLC Thalidomide-4-O-C9-NH2 (hydrochloride) | 99.3% | 451.94 | 5 MG
Thalidomide-4-O-C9-NH2 (hydrochloride) is a solid laboratory chemical with a molecular weight of 451.94 and the chemical formula C22H30ClN3O5. It is stable under recommended storage conditions.
- Solid appearance, light yellow to yellow
- Purity of 99.3%
- Stable under recommended storage conditions
- Long-term storage at -20°C (solid) or -80°C (in solvent)
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 50 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate designed for research purposes. It integrates a thalidomide-based cereblon ligand and a linker, both crucial components utilized in PROTAC (Proteolysis Targeting Chimeras) technology. This product is not intended for patient use.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Includes a linker commonly used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Appears as a white to off-white solid
- Available in various quantities with specific storage guidelines
- Supplied with a Data Sheet, Certificate of Analysis (COA), Safety Data Sheet (SDS), and Handling Instructions
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g/mol | C13H10N2O5 | 5 G
Thalidomide-4-OH is a 4-hydroxylated thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein degradation research. It is commonly used as a building block in PROTAC design and medicinal chemistry studies and is supplied as a solid for laboratory research use only.
- Acts as a cereblon (CRBN) ligand suitable for PROTAC synthesis.
- 4-hydroxyl substitution enables linker attachment for conjugation.
- High purity supports reproducible conjugation and biological assays.
- Solid form allows convenient storage and handling.
- Useful for ligand optimization and E3 ligase recruitment studies.