Lactams
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
Medchemexpress LLC Thalidomide-PEG4-Propargyl | 2098799-77-8 | MFCD32207014 | >96.5% | 488.49 | 1 MG
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thalidomide-5-CH2-NH2 hydrochloride | 1010100-22-7 | MFCD32666042 | 98.6% | 323.73 g/mol | C14H14ClN3O4 | 25 MG
Thalidomide-5-CH2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt. It provides a reactive primary amine at the 5-position for linker attachment and is used as an E3 ligase recruiting moiety in PROTAC design and related chemical biology research. Suitable for medicinal chemistry and linker-conjugation workflows.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | C25H36ClN5O9 | 5 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG4-C2 spacer. Supplied as the hydrochloride salt in solid form and reported at high purity, the compound is intended as a building block for PROTAC design and other CRBN-recruiting chemical biology applications.
- E3 ligase ligand-linker conjugate for PROTAC construction.
- Includes a thalidomide-based cereblon ligand to recruit CRBN proteins.
- PEG4-C2 linker with terminal amine for facile conjugation.
- Hydrochloride salt form to aid handling and solubility.
- High purity suitable for synthetic and research workflows.
Medchemexpress LLC CD23/Fc epsilon RII 50ug
CD23/Fc epsilon RII Protein a low-affinity receptor for IgE and CR2/CD21 regulates IgE production and B cell differentiation On B cells it initiates IgE-dependent antigen uptake and presentation to T cells On macrophages IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding CD23/Fc epsilon RII Protein Mouse (HEK293 His) is the recombinant mouse-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-His labeled tag
Medchemexpress LLC Fc epsilon RIA/FCER1 10ug
Recombinant human Fc epsilon RIA (FCER1A) is the extracellular alpha chain of the high-affinity IgE receptor supplied as a His-SUMO-tagged recombinant protein. The lyophilized protein is intended for use in binding studies, ELISA, and other immunological or biochemical assays requiring the human FCER1A ectodomain.
- His-SUMO tagged protein for affinity purification and detection.
- Expressed in E. coli and supplied lyophilized for enhanced stability.
- Purity >95% as determined by reducing SDS-PAGE.
- Formulated with trehalose and EDTA for increased storage stability.
- Suitable for ELISA and binding assays; functional activity characterized.
- Recommended reconstitution at or above 100 μg/mL for optimal performance.
Medchemexpress LLC CD3 epsilon Canine 10ug | 10ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC CD3 epsilon Human 500ug
Recombinant human CD3 epsilon protein produced in HEK293 mammalian cells and supplied as a lyophilized preparation with a C-terminal 6xHis tag, intended for research use in studies of T-cell receptor signaling, binding assays, and related immunological applications. Lot-specific COA provides detailed formulation and buffer information.
- Produced in HEK293 mammalian expression system.
- C-terminal 6xHis tag for detection and purification.
- Lyophilized powder formulation for convenient storage and handling.
- Approximate molecular weight 18-21 kDa by SDS-PAGE.
- Stable at -20 °C for long-term storage; reconstituted stability at 4 °C for one week.
- Lot-specific COA and datasheet available for quality and formulation details.