Lactams
Medchemexpress LLC Thalidomide-o-amido-c3-peg3-c1-nh2 trifluoroacetate | 1799711-29-7 | MFCD32878273 | 99.1% | C27H35F3N4O11 | 10MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that couples a thalidomide-derived cereblon ligand to a three-unit polyethylene glycol linker, designed for PROTAC synthesis and related chemical biology research. The compound is supplied as an off-white to light yellow oil, with molecular formula C27H35F3N4O11, molecular weight 648.58 g·mol⁻¹, and high purity suitable for research.
- Contains a thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Includes a three-unit polyethylene glycol linker to enhance flexibility and solubility.
- Designed for PROTAC design and targeted protein degradation studies.
- High purity (99.1%) for consistent experimental results.
- Characterized molecular properties facilitate reproducible use in research.
- Available in small packaging sizes suitable for laboratory studies.
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | MFCD32694133 | 548.59 g·mol-1 | C26H36N4O9 | 10 MG
Thalidomide-NH-PEG3-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate bearing a three-unit polyethylene glycol spacer and a Boc-protected terminal amine. It is provided as a synthetic intermediate for medicinal chemistry and chemical biology applications, especially for constructing cereblon-recruiting PROTACs.
- Boc-protected terminal amine for controlled deprotection and conjugation.
- PEG3 spacer offers flexibility and improved solubility for bifunctional molecules.
- Designed as an intermediate for CRBN-targeting PROTAC synthesis.
- Soluble in DMSO and compatible with standard in vivo formulation protocols.
- Store frozen to maintain stability.
Medchemexpress LLC Thalidomide-5-peg2-cl | 2230956-57-5 | 96.6% | 380.78 g/mol | C17H17ClN2O6 | 5 MG
Thalidomide-5-PEG2-Cl is a thalidomide-derived cereblon ligand intended for use as the E3 ligase-recruiting component in proteolysis-targeting chimera (PROTAC) synthesis. It contains a two-unit polyethylene glycol linker and a terminal chloro functional group to facilitate conjugation to target ligands. Intended for research use only.
- Enables cereblon recruitment in PROTAC constructs.
- Contains a PEG2 linker for flexible conjugation.
- Terminal chloro group for facile chemical coupling.
- High purity suitable for research applications.
- Available in small milligram quantities for screening and synthesis.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | C22H27N3O9 | 5 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a carboxylic acid. It is intended as a modular building block for PROTAC development to recruit CRBN and enable linker attachment to target-binding ligands.
- Designed for PROTAC assembly and CRBN recruitment.
- Contains a PEG3 linker terminating in a carboxylic acid for facile conjugation.
- Incorporates a thalidomide-based cereblon ligand.
- High chemical purity (≈98.9%).
- Suitable for medicinal chemistry and chemical biology applications.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 440.88 g·mol⁻1 | C19H25ClN4O6 | 5 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the hydrochloride salt for research use. It combines a thalidomide cereblon-binding moiety with a two-unit polyethylene glycol spacer and a C2 amino termination, designed for incorporation into PROTAC constructs and linker chemistry in targeted protein degradation studies.
- Provides a thalidomide-derived cereblon binding motif suitable for E3 ligase recruitment.
- Contains a PEG2 spacer to improve solubility and linker flexibility.
- Terminates in a C2 amino handle for straightforward conjugation chemistry.
- Supplied as the hydrochloride salt for enhanced stability and handling.
- Characterized with reported molecular weight and purity for research applications.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | 99.6% | 660.67 g/mol | C23H30F3N5O9 | 25 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a trifluoroacetate salt E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker for use in PROTAC synthesis and related chemical biology research. It is supplied as a high-purity solid and is intended for research use only.
- Contains a thalidomide-based cereblon ligand for cereblon-mediated degradation studies.
- PEG3 linker provides flexibility and solubility for linker optimization in PROTAC design.
- Offered as a solid TFA salt for convenient handling and storage.
- High purity suitable for synthetic chemistry and biological probe development.
- Recommended storage: powder at -20°C; in solution, store at -80°C for long-term preservation.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.
- Provides a cereblon-binding thalidomide ligand for PROTAC design.
- Includes a PEG3 linker to improve solubility and flexibility.
- Features a C2 amine handle for facile coupling to warheads.
- Offered as the TFA salt to aid handling and stability.
- Supplied at high purity (>98%) suitable for synthetic use.
- Available in small research-scale quantities for method development.