Lactones
Selleck Chemical LLC ATN-161
ATN-161 is a novel small peptide antagonist of integrin 5 1 It binds to several integrins including 5 1 and v 3 that play a role in angiogenesis and tumor progression
Medchemexpress LLC Not listed on product page; chemical name not found in accessible SDS | 1206731-57-8 | 98.4% | 458.55 | C27H30N4O3 | 1 ML
This compound is a potent, selective histone deacetylase 6 (HDAC6) inhibitor used in biochemical and cellular research to probe HDAC6-related pathways. It also shows activity against metallo-β-lactamase domain-containing protein 2 (MBLAC2) and is supplied as a ready-to-use solution for in vitro studies.
- Potent HDAC6 inhibition (IC50 = 0.40 nM).
- Also inhibits MBLAC2, enabling dual-target studies.
- High purity (98.4%) suitable for biochemical assays.
- Molecular weight 458.55, formula C27H30N4O3.
- Supplied as 10 mM 1 mL solution in DMSO; solid formats available.
- Soluble ≥100 mg/mL in DMSO; store solutions at -80°C for long-term stability.
Medchemexpress LLC Butyrolactone 3 | 778649-18-6 | 99.6% | 50 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5, with an IC50 of 100 μM. It exhibits high affinity for the Gcn5 enzyme, similar to its natural substrate, histone H3, and shows weak inhibitory effects on CBP (IC50=0.5 mM). This compound is intended for research use only and is utilized in studies related to cancer, metabolic, autoimmune, and neurological diseases.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5
- Exhibits high affinity for Gcn5 enzyme
- Shows weak inhibitory effects on CBP
- Suitable for research in cancer, metabolic, autoimmune, and neurological diseases
Medchemexpress LLC 11-Keto-beta-boswellic acid | 17019-92-0 | 470.68 | 1 ML
11-Keto-beta-boswellic acid is a pentacyclic triterpenic acid derived from the oleogum resin of the Boswellia serrata tree, commonly known as Indian Frankincense. It possesses anti-inflammatory activity primarily by inhibiting 5-lipoxygenase (5-LOX) and subsequently leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.
- Anti-inflammatory activity
- Anti-diabetic activity observed in streptozotocin-induced diabetic rats
- Protects rats against kainic acid-induced excitotoxicity
- Solid, white to off-white appearance
Medchemexpress LLC Butyrolactone 3 (MB-3) | 778649-18-6 | 99.6% | 1 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM). It exhibits high affinity for the Gcn5 enzyme, comparable to its natural substrate, histone H3. It shows weak inhibition on CBP (IC50=0.5 mM) and can be used in studies of cancer, metabolic, autoimmune, and neurological diseases. This product is for research use only.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5 (IC50=100 μM).
- High affinity for the Gcn5 enzyme, comparable to histone H3.
- Weak inhibition on CBP (IC50=0.5 mM).
- Used in studies of cancer, metabolic, autoimmune, and neurological diseases.
- Purity of 99.58%.
- Molecular weight of 184.19.
- Chemical formula: C9H12O4.
- Solid, white to off-white appearance.
- Recommended storage for powder: -20°C for 3 years.
- Solutions are unstable; freshly prepared solutions are recommended.
Apexbio Technology LLC L-161,982(Synonyms: L-161982, L161982, EP4 Receptor Antagonist L-161982, EP4 antagonist L-161982), 1mg, CAS: 147776-06-5.
L-161 982 (CAS 147776-06-5) is a selective antagonist of the prostaglandin E2 receptor subtype EP4 By specifically blocking EP4 signaling this compound modulates downstream pathways associated with inflammation and cell proliferation In vitro studies indicate that inhibition of EP4 by L-161 982 reduces ERK phosphorylation and consequently suppresses proliferation of the HCA-7 cell line Additionally rodent studies demonstrate that L-161 982 alleviates collagen-induced arthritis underscoring its utility in investigating EP4-related inflammatory processes and disease mechanisms
Medchemexpress LLC Beta-propiolactone | 57-57-8 | MFCD00005169 | 99.4% | 72.06 g/mol | C3H4O2 | 1 ML
Propiolactone (beta-propiolactone) is a small, reactive four-membered lactone (C3H4O2, 72.06 g/mol) provided as a 10 mM solution in DMSO for laboratory research. It is commonly used as a viral chemical inactivator and as a reactive reagent in biochemical and virology workflows. Handle with appropriate personal protective equipment and consult the SDS before use.
- Supplied as a 10 mM solution in DMSO, 1 mL vial.
- High purity suitable for research applications.
- Reactive lactone used for viral inactivation and chemical modification.
- Stable when stored frozen; follow storage recommendations.
- For research use only; not for human or clinical use.
Medchemexpress LLC Beta-propiolactone | 57-57-8 | MFCD00005169 | 99.4% | 72.06 g/mol | C3H4O2 | 250 MG
Propiolactone (beta-propiolactone) is a small, reactive lactone used primarily as a chemical viral inactivator and bacteriostatic agent in research and vaccine formulation. It is supplied as a high-purity reagent for laboratory applications that require reliable viral inactivation; the chemical is reactive and should be handled with appropriate safety precautions.
- High purity (99.36%) suitable for research use.
- Molecular weight 72.06 g/mol for analytical calculations.
- Used as a chemical viral inactivator and bacteriostatic agent.
- Available in multiple pack sizes, including 250 mg.
- Chemical formula C3H4O2; synonyms include β-propiolactone and 2-oxetanone.
Apexbio Technology LLC Butyrolactone 3 778649-18-6 5mg
Butyrolactone 3 (CAS 778649-18-6) is a small-molecule inhibitor that targets the histone acetyltransferase Gcn5 a member of the GNAT family with specificity for histone H3 acetylation In vitro studies demonstrate that Butyrolactone 3 inhibits Gcn5 activity with an IC50 of 100 M while showing minimal inhibition of CBP The binding affinity of Butyrolactone 3 to Gcn5 is comparable to that of histone H3 and its inhibition is non-irreversible indicating it does not act via a Michael addition mechanism Structurally modification at position 2 has been suggested as a basis for structure activity relationship (SAR) studies Currently Butyrolactone 3 is utilized in preclinical research aimed at modulating Gcn5-mediated histone acetylation
Medchemexpress LLC Butyrolactone 3 (MB-3) | 778649-18-6 | 99.6% | 10 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5, with an IC50 of 100 μM. It demonstrates high affinity for the Gcn5 enzyme, similar to its natural substrate, histone H3, and shows weak inhibition of CBP (IC50 = 0.5 mM). This compound is suitable for studies related to cancer, metabolic, autoimmune, and neurological diseases.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5
- High affinity for the Gcn5 enzyme
- Weak inhibition of CBP
- Can be used in studies of cancer, metabolic, autoimmune, and neurological diseases
Selleck Chemical LLC Butyrolactone 3-E1387-1MG
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50 100 M) which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate histone H3 Butyrolactone 3 shows weak inhibitory on CBP (IC50 0 5 mM) Butyrolactone 3 can be used in studies of cancer metabolic autoimmune and neurological diseases
Selleck Chemical LLC ATN-161
ATN-161 is a novel small peptide antagonist of integrin 5 1 It binds to several integrins including 5 1 and v 3 that play a role in angiogenesis and tumor progression
AdipoGen Butyrolactone I
Chemical. CAS 87414-49-1. Formula C24H24O7. MW 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 CDC2, -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
Apexbio Technology LLC Butyrolactone 3 778649-18-6 1mg
Butyrolactone 3 (CAS 778649-18-6) is a small-molecule inhibitor that targets the histone acetyltransferase Gcn5 a member of the GNAT family with specificity for histone H3 acetylation In vitro studies demonstrate that Butyrolactone 3 inhibits Gcn5 activity with an IC50 of 100 M while showing minimal inhibition of CBP The binding affinity of Butyrolactone 3 to Gcn5 is comparable to that of histone H3 and its inhibition is non-irreversible indicating it does not act via a Michael addition mechanism Structurally modification at position 2 has been suggested as a basis for structure activity relationship (SAR) studies Currently Butyrolactone 3 is utilized in preclinical research aimed at modulating Gcn5-mediated histone acetylation
![eMolecules Medchem Express / Butyrolactone I / 1mg / 784543713 / HY-111237 / / 87414-49-1 / [null] / 424.449 / C24H24O7](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502471323.JPG-250.jpg)
eMolecules Medchem Express / Butyrolactone I / 1mg / 784543713 / HY-111237 / / 87414-49-1 / [null] / 424.449 / C24H24O7
Medchem Express / Butyrolactone I / 1mg / 784543713 / HY-111237 / / 87414-49-1 / [null] / 424.449 / C24H24O7